Proliferating tricholemmal tumour with lymph node metastases

Aricò, Mario; Rocca, Eleonora La; Noto, Giuseppe; Pravatà, G; Rodolico, Vito

doi:10.1111/j.1365-2133.1989.tb08224.x

Cited by 12 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16 Three distinctive tumours of hair sheath can be recognised and as they are relatively common their differentiating features deserve brief comment.…”

Section: Pilosebaceous Tumoursmentioning

confidence: 99%

Troublesome tumours. 1: Adnexal tumours of the skin.

Cotton¹

1991

J Clin Pathol

View full text Add to dashboard Cite

“…16 Three distinctive tumours of hair sheath can be recognised and as they are relatively common their differentiating features deserve brief comment.…”

Section: Pilosebaceous Tumoursmentioning

confidence: 99%

Troublesome tumours. 1: Adnexal tumours of the skin.

Cotton¹

1991

J Clin Pathol

View full text Add to dashboard Cite

“…Proliferative forms of pilar cysts are rare and exist on a spectrum that can range from benign proliferating pilar tumors (BPPTs) to malignant proliferating pilar tumors (MPPTs) 2 . MPPT is a rare tumor that can exhibit distant metastasis, predominantly to lymph node 3–9 . Due to the tumor’s rarity, the literature is comprised mainly of case reports 3–9 …”

mentioning

confidence: 99%

“…MPPT is a rare tumor that can exhibit distant metastasis, predominantly to lymph node 3–9 . Due to the tumor’s rarity, the literature is comprised mainly of case reports 3–9 …”

mentioning

confidence: 99%

“…2 MPPT is a rare tumor that can exhibit distant metastasis, predominantly to lymph node. [3][4][5][6][7][8][9] Due to the tumor's rarity, the literature is comprised mainly of case reports. [3][4][5][6][7][8][9] The histologic differential diagnosis of BPPT and MPPT includes cutaneous squamous cell carcinoma (SCC) and its cystic variants, and differentiation between these entities can be difficult, especially in superficial biopsies or incomplete excisions.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Malignant Proliferating Pilar Tumor

Moran

DeSimone

Mariño-Enríquez

et al. 2023

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Proliferating pilar tumors are rare neoplasms that differentiate toward the outer sheath near the isthmus and can rarely undergo malignant transformation. We performed histopathologic evaluation on 26 benign proliferating pilar tumor (BPPT) and 17 malignant proliferating pilar tumor (MPPT). Ki-67 and p53 immunostains were performed on 13 BPPT and 10 MPPT. Six MPPT cases were successfully analyzed by a next-generation sequencing platform which surveyed exonic DNA sequences of 447 cancer genes and 191 regions across 60 genes for rearrangement detection. Patient demographics and clinical characteristics were similar between the BPPT and MPPT groups. Follow-up data of 16 of 17 MPPT (median, 25 mo) showed metastasis in 1 MPPT. The histologic features associated with MPPT include size >2.5 cm, adjacent desmoplastic stroma, small nests or cords of atypical epithelium in surrounding stroma, irregular infiltration or borders, abnormal keratinization, large hyperchromatic nuclei, prominent nucleoli, severe cytologic atypia, nuclear pleomorphism, necrosis, and increased mitotic figures. MPPT harbors copy number gains of 15q and losses of 6p and 6q, findings previously reported in BPPT. However, MPPT harbors frequent TP53 mutations as molecular markers of progression. Different from cutaneous squamous cell carcinoma, MPPT more frequently demonstrates low tumor mutational burden and typically lacks a UV signature, suggestive of a different etiologic pathway than squamous cell carcinoma. In summary, with a median follow-up of 25 months, this study shows that MPPT is a biologically indolent carcinoma with rare metastasis. Molecular analyses suggest a non–UV-related pathogenesis with frequent TP53 aberration.

show abstract

“…The tumor usually has a diameter of <2 cm (12). An accurate diagnosis of MPTT relies on a pathological examination, and therapeutic strategies include surgery, radiotherapy, chemotherapy and cryotherapy (13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Surgical treatment of rare giant malignant tumors of the scalp: A report of 3 cases with different tumor types

Liu

Yuan

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. The scalp is the most frequent site of occurrence of malignant tumors. As an area that is generally neglected by the patient and not closely monitored during physical examinations, scalp tumors can go unnoticed until they become malignant. The present study reports 3 cases of rare giant malignant tumors of the scalp, namely a peripheral nerve sheath tumor, a fibrous tumor and a malignant proliferating trichilemmal tumor, that were treated at The First Bethune Hospital of Jilin University (Changchun, China). Vascularized free anterolateral thigh flap surgery was performed in 2 of the 3 cases. A local flap repair was applied to the third case. The implanted skin grafts remained viable post-operatively and wound repair was uneventful. No signs of malignancy were detected on the edge of the pathological section upon closer pathological examination. In the follow-up period, no recurrence was detected in any of the cases.

show abstract

Proliferating tricholemmal tumour with lymph node metastases

Abstract: A 42-year-old woman with a proliferating tricholemmal tumour (PTT) with regional lymph node metastases is reported. Histochemical studies showed evidence of tricholemmal keratinization. There was recurrence following excision and subsequently the patient developed lymph node metastases.

Cited by 12 publications

References 8 publications

Troublesome tumours. 1: Adnexal tumours of the skin.

Troublesome tumours. 1: Adnexal tumours of the skin.

Malignant Proliferating Pilar Tumor

Surgical treatment of rare giant malignant tumors of the scalp: A report of 3 cases with different tumor types

Contact Info

Product

Resources

About