Proliferation and differentation markers in snuff‐induced oral mucosal lesions

Abstract

The findings of this study showing suppressed cellular proliferation and infrequent p53 dysfunction in snuff lesions may partly explain why dysplastic changes are seldom seen in mucosal lesions induced by the Scandinavian type of snuff.

Oral squamous cell carcinoma versus oral verrucous carcinoma: an approach to cellular proliferation and negative relation to human papillomavirus (HPV)

“…In the VC group, we only detected a strong expression of Ki-67 and cyclin B1 proteins in the basal and parabasal layers of the epithelium, whereas the expression of PCNA was seen in all of the epithelial layers. This data is in agreement with data in the literature [26]. We believe that the higher proliferation index for PCNA was due to the similarity between the VC and CT groups.…”

“…A high proliferation index percentage of PCNA was found in the CT group (100%) when compared to the SCC group, and this result was also detected by the study of Merne et al [26]. We believe that in the CT group, the cell cycle was working under natural conditions and since PCNA is characterized by a longer half-life, it was thus detectable in many cells that had already passed through the cycle.…”

“…In recent times, many investigations of cellular proliferation in neoplastic lesions have been undertaken and several different methods have been developed to detect it in malignancies [23][24][25][26][27][28][29][30][31][32][33]. However, few studies have investigated the relationship between the cellular proliferation index and the presence of HPV [24,25,30,31].…”

“…Cell proliferation is defined as an "increase in cell number resulting from completion of the cell cycle" [24][25][26][27]. Many different methods have been developed to detect cell proliferation in malignancies.…”

“…Many different methods have been developed to detect cell proliferation in malignancies. In order to verify the proliferative activity in SCC, markers of cellular proliferation have been investigated by immunohistochemical techniques and the proliferative index has been shown to be relevant in determining the prognosis of oral SCC [24][25][26][27][28].…”