Proliferation and differentiation markers of colorectal adenocarcinomaand their correlation with clinicopathological factors

Ajtić, Olivera Mitrović; Todorović, Slobodan; Diklić, Miloš; Subotički, Tijana; Beleslin-Čokić, Bojana B.; Jovčić, Gordana; Čokić, Vladan P.

doi:10.3906/sag-1412-85

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…The circulating microRNAs markers miR-122 and miR-200 family members could be used in the development of a multi-marker blood test for colorectal cancer prognosis and survival[32]. The decreased erythropoietin expression, high vascular endothelial growth factor levels and elevated cyclin B1 expression, predominant moderate tumour differentiation, absence of metastasis, and negative lymph node status are reliable proliferation and differentiation markers indicating the low level of aggressiveness, better prognosis, and longer colorectal adenocarcinoma patient’s survival[33]. By means of solid-phase proximity ligation assay, 35 protein markers were simultaneously analyzed in a small amount of blood of stage I to IV colorectal cancer patients, however, these markers did not give better prognostic information than CEA[34].…”

Section: Discussionmentioning

confidence: 99%

International scientific communications in the field of colorectal tumour markers

Ivanov

Donev

2017

WJGS

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AIMTo analyze scientometrically the dynamic science internationalization on colorectal tumour markers as reflected in five information portals and to outline the significant journals, scientists and institutions.METHODSA retrospective problem-oriented search was performed in Web of Science Core Collection (WoS), MEDLINE, BIOSIS Citation Index (BIOSIS) and Scopus for 1986-2015 as well as in Dervent Innovations Index (Derwent) for 1995-2015. Several specific scientometric parameters of the publication output and citation activity were comparatively analyzed. The following scientometric parameters were analyzed: (1) annual dynamics of publications; (2) scientific institutions; (3) journals; (4) authors; (5) scientific forums; (6) patents - number of patents, names and countries of inventors, and (7) citations (number of citations to publications by single authors received in WoS, BIOSIS Citation Index and Scopus).RESULTSThere is a trend towards increasing publication output on colorectal tumour markers worldwide along with high citation rates. Authors from 70 countries have published their research results in journals and conference proceedings in 21 languages. There is considerable country stratification similar to that in most systematic investigations. The information provided to end users and scientometricians varies between these data-bases in terms of most parameters due to different journal coverage, indexing systems and editorial policy. The lists of the so-called “core” journals and most productive authors in WoS, BIOSIS, MEDLINE and Scopus along with the list of the most productive authors - inventors in Derwent present a particular interest to the beginners in the field, the institutional and national science managers and the journal editorial board members. The role of the purposeful assessment of scientific forums and patents is emphasized.CONCLUSIONOur results along with this problem-oriented collection containing the researchers’ names, addresses and publications could contribute to a more effective international collaboration of the coloproctologists from smaller countries and thus improve their visibility on the world information market.

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Section: Discussionmentioning

confidence: 99%

International scientific communications in the field of colorectal tumour markers

Ivanov

Donev

2017

WJGS

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“…Faktori rizika koji se mogu promeniti uključuju alkohol, pušenje, gojaznost i neke lekove. Nepromenljivi faktori rizika uključuju pol, starost, dijabetes, te faktore koji se tiču samog tumora [29,30].…”

Section: Endoskopska Vakuum Terapija U Kolorektalnoj Hirurgijiunclassified

“…Jedna od novouvedenih metoda za lečenje komplikacije popuštanja anastomoze je endoskopska va-upotreba negativnog pritiska u terapiji rana use of negative pressure in wound therapy include alcohol, smoking, obesity, and some medications. Non-modifiable risk factors include sex, age, diabetes, and factors related to the tumor itself [29,30].…”

Section: Endoskopska Vakuum Terapija U Kolorektalnoj Hirurgijimentioning

confidence: 99%

Use of negative pressure in wound therapy

Todorović,

Tošković,

Gačić

et al. 2023

Srpski medicinski časopis Lekarske komore

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The use of negative pressure in wound therapy is an innovative therapeutic method that accelerates the wound healing process. This technique is applied to various types of acute and chronic wounds and can shorten their healing time and improve the quality of the scars. Negative pressure therapy acts on the wound by improving blood circulation, reducing swelling, promoting the growth of granulation tissue, reducing the risk of infection, and improving the quality of scar formation. At the molecular level, negative pressure increases the expression of cytokines and growth factors that promote angiogenesis, extracellular matrix remodeling, and tissue regeneration. Negative pressure therapy, as one of the techniques for temporary abdominal closing, is used in situations where the abdominal cavity must remain open for some time, in complex injuries, infections, and where there is a risk of compartment syndrome. In recent years, endoscopic vacuum therapy, a minimally invasive modality of treatment in colorectal surgery and surgery of the upper gastrointestinal tract, has emerged. The possibilities of this therapy have not been completely exhausted. In addition to its multiple applications, it has been shown that negative pressure therapy reduces treatment costs, shortens the duration of hospital stay, and enables faster patient recovery.

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“…Usvajanjem jednoobraznog uputstva za pripremu rada, povećao se broj mladih istraživača koji tokom stasavanja u poznate naučnike, pripremaju doktorske/magistarske teze [30], i objavljuju rukopise u prestižnim domaćim [31,32] ili svetskim časopisima [33][34][35][36]. Obaveza svakog istraživača, je da deluje u skladu sa etičkim normama naučno-istraživačkog kodeksa, i da učestvuje u otkrivanju i suzbijanju svakog oblika devijantnog ponašanja.…”

Section: Diskusija I Zaključakunclassified

Scientific misconduct

Todorović¹,

Tošković²,

Čolaković³

et al. 2020

Halo 194

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With the creation of a global computer network, the internet, all manner of information has become available to scientists and everyone else around the world. The exchange of information gives scientists insight into the most recent scientific discoveries while enabling them at the same time to use the information for their research. Scientists and experts must be sure that their colleagues' research is valid, objective and the results complete. These scientific research characteristics represent scientific honesty. Scientific misconduct can take various forms and can be present in all phases of the scientific research process, but most commonly takes the form of fabrication, falsification and plagiarism. The reasons for scientific misconduct can be personal, professional and financial. There is also a "grey zone", which consists of data manipulation and selection, reference citing mistakes, multiple and salami publications, problematic authorships. Every type of misconduct has a detrimental effect on the scientific community. In the public eye, scientists are benevolent seekers of truth with high moral integrity, whose work is of key value to society. Any type of scientific misconduct serves to dishonour the scientific community but also brings confusion into the work of other researchers, therefore significantly slowing down scientific discovery in whole. Digitalization and technological advancement significantly contribute to the early discovery, elimination and sanctioning of any kind of research misconduct. A significant improvement in solving these problems can be achieved through adequate education of young researchers and introducing laws that precisely define penalties for breaking the code of good scientific practice.

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Proliferation and differentiation markers of colorectal adenocarcinomaand their correlation with clinicopathological factors

Cited by 4 publications

References 22 publications

International scientific communications in the field of colorectal tumour markers

International scientific communications in the field of colorectal tumour markers

Use of negative pressure in wound therapy

Scientific misconduct

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