Proliferation and osteogenic differentiation of human mesenchymal stem cells on zirconia and titanium with different surface topography

Hirano, Tomoki; Sasaki, Hodaka; Honma, Shinya; Miura, Tadashi; Yajima, Yasutomo; Yoshinari, Masao

doi:10.4012/dmj.2015-129

Cited by 38 publications

(39 citation statements)

References 28 publications

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“…The cellular viability results obtained in our study showed that Ti grade V had the lowest percentage of cell proliferation among the test groups. These results are similar to those of previous studies regarding the presence or not of bioactive ceramics in titanium . At all times of cell culture assessment, the control group (well plates) showed the highest values of cell viability, due to the high roughness of the polystyrene based material which is proper for cell culture.…”

Section: Discussionsupporting

confidence: 90%

Bioactivity of novel functionally structured titanium‐ceramic composites in contact with human osteoblasts

Peñarrieta‐Juanito

Costa

Cruz

et al. 2018

J Biomedical Materials Res

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The aim of this study was to analyze the osteogenic cell behavior on the surface of novel functionally graded titanium-based composites containing bioactive ceramics. Titanium grade V discs (8 × 3 mm) embedding gradual content of hydroxyapatite (TiAlV-HA) or beta-tricalcium phosphate (TiAlV-βTCP) were produced by hot-pressing technique. Titanium-ceramic composite discs and Ti grade V (control group) were placed in contact with human osteoblast culture assays. The morphology and adhesion of osteoblasts were inspected by field emission guns scanning electron microscopy (FEGSEM) while cell viability was assessed by fluorometric method. Alkaline phosphatase (ALP) activity and fluorescent microscopic analyses were used to evaluate mineralization on the test and control discs. FEGSEM images showed cells adhered to Ti6Al4V-ceramic and Ti6Al4V surfaces over a period of 24 h, and therefore, an intense proliferation of osteoblasts and spreading cells was noticed for 7 days. Cell viability increased with time on all the surfaces although TiAlV-βTCP revealed significant higher percentage of cell viability than that recorded for TiAlV-HA (p < 0.01). TiAlV-βTCP also showed the highest hydrophilic character. ALP levels increased on the Ti6Al4V-ceramic surfaces when compared to the control group. Also, a qualitative analysis of mineralization evidenced an increase in mineral content on TiAlV-HA or TiAlV-βTCP groups. Novel functionally graded composites based on Ti grade V and hydroxyapatite or βTCP showed a higher bioactivity in presence of osteoblasts than that recorded on Ti grade V. Also, such functionally graded materials can prevent risks of failures by detachment of bioactive ceramic materials during implant placement. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1923-1931, 2018.

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Section: Discussionsupporting

confidence: 90%

Bioactivity of novel functionally structured titanium‐ceramic composites in contact with human osteoblasts

Peñarrieta‐Juanito

Costa

Cruz

et al. 2018

J Biomedical Materials Res

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“…A number of animal studies have been published that outline hard and soft tissue integration of zirconia implants on the histological level and have shown promising results [29, 32, 33]. Further, cell culture studies have demonstrated that zirconia especially with a moderately rough surface is accepted by osteoblasts and integrates into bone tissue [9, 34]. Scarano et al [35] examined the bone-implant interface of machined zirconia implants at 4 weeks of healing and reported BIC values of 68.4%.…”

Section: Discussionmentioning

confidence: 99%

Effect of Zirconia Dental Implant Surfaces on Bone Integration: A Systematic Review and Meta-Analysis

Hafezeqoran

Koodaryan

2017

BioMed Research International

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Background. The information available about osseointegration and the bone to implant interaction of zirconia implants with various surface modifications is still far from sufficient. Objective. The purpose of this systematic review and meta-analysis was to evaluate and compare zirconia dental implants with different surface topographies, with a focus on bone to implant contact and removal torque. Methods. The systematic review of the extracted publications was performed to compare the bone to implant contact (BIC) with removal torque (RT) values of titanium dental implants and machined and surfaced modified zirconia implants. Results. A total of fifteen articles on BIC and RT values were included in the quantitative analysis. No significant difference in the BIC values was observed between titanium and machined zirconia implants (p = 0.373; 95% CI: −0.166 to 0.443). However, a significantly better BIC values were observed for acid etched zirconia implants compared with those of titanium implants (p = 0.032; 95% CI: 0.068 to 1.461). Unmodified zirconia implants showed favorable BIC values compared to modified-surface zirconia implants (p = 0.021; 95% CI: −0.973 to −0.080). Conclusion. Acid etched zirconia implants may serve as a possible substitute for successful osseointegration.

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“…A combination of shot blasting and acid etching is often performed on Cp-Ti implants because it reportedly accelerates osseointegration [8][9][10][11][12][13][14][15] . In vitro experiments have demonstrated that the combination promotes adhesion, proliferation, and differentiation of osteoblasts [11][12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

“…In vitro experiments have demonstrated that the combination promotes adhesion, proliferation, and differentiation of osteoblasts [11][12][13][14][15] . In vivo experiments have demonstrated that it improves bone-implant contact and increases removal torque [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Influence of grade and surface topography of commercially pure titanium on fatigue properties

et al. 2018

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The objective was to investigate the influence of grade and surface topography of commercially pure titanium (Cp-Ti) on fatigue properties evaluated via staircase method. Cp-Ti grades 2 and 4 were roughened by shot blasting and acid etching, and compared with machined specimens. Yield force under static loading for Cp-Ti grades 2 and 4 were 672±51 and 1,088±93 N for machined and 724±99 and 1,118±96 N for roughened group. Yield force under cyclic loading for Cp-Ti grades 2 and 4 decreased 27 and 40% compared to static loading. Cp-Ti grade 4 demonstrated significantly greater decrease in yield force after cyclic loading; however surface topography had no effect.

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Proliferation and osteogenic differentiation of human mesenchymal stem cells on zirconia and titanium with different surface topography

Cited by 38 publications

References 28 publications

Bioactivity of novel functionally structured titanium‐ceramic composites in contact with human osteoblasts

Bioactivity of novel functionally structured titanium‐ceramic composites in contact with human osteoblasts

Effect of Zirconia Dental Implant Surfaces on Bone Integration: A Systematic Review and Meta-Analysis

Influence of grade and surface topography of commercially pure titanium on fatigue properties

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