Proliferation of donor mitochondrial DNA in nuclear transfer calves (<i>Bos taurus</i>) derived from cumulus cells

Takeda, Kumiko; Akagi, Satoshi; Kaneyama, Kanako; Kojima, Toshiyuki; Takahashi, Seiya; Imai, Hiroshi; Yamanaka, Mariko; Ōnishi, Akira; Hanada, Hirofumi

doi:10.1002/mrd.10279

Cited by 83 publications

(96 citation statements)

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“…Intraorganismal selection on mitochondrial variants The effective organelle number may also be reduced by temporal variations of the number of organelles per has been documented in several species including Drosophila, mice, and humans (Shoubridge et al 1990; cell. In mammals, rapid changes in heteroplasmy levels between generations have led to the hypothesis of a Yoneda et al 1992;Dunbar et al 1995;De Stordeur 1997;Jenuth et al 1997;Doi et al 1999; Moraes et al mitochondrial bottleneck during the development of the female germline (Hauswirth andLaipis 1982, 1999;Takeda et al 2000). Both point mutations and deletions in mtDNA can be selected within the organism; 1985; Laipis et al 1988;Koehler et al 1991).…”

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Germline Bottlenecks, Biparental Inheritance and Selection on Mitochondrial Variants

2005

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Selection on mitochondrial mutations potentially occurs at different levels: at the mitochondria, cell, and organism levels. Several factors affect the strength of selection at these different levels; in particular, mitochondrial bottlenecks during germline development and reduced paternal transmission decrease the genetic variance within cells, while they increase the variance between cells and between organisms, thus decreasing the strength of selection within cells and increasing the strength of selection between cells and organisms. However, bottlenecks and paternal transmission also affect the effective mitochondrial population size, thus affecting genetic drift. In this article, we use a simple model of a unicellular life cycle to investigate the effects of bottlenecks and paternal transmission on the probability of fixation of mitochondrial mutants and their frequency at mutation-selection equilibrium. We find that bottlenecks and reduced paternal transmission decrease the mean frequency of alleles with s m Ͼ s c (approximately), where s m and s c are the strengths of selection for an allele within and between cells, respectively, and increase the frequency of alleles with s m Ͻ s c . Effects on fixation probabilities are different; for example, bottlenecks reduce the fixation probability of mutants with s m Ͼ 0 (unless s m is very small relative to s c ) and increase the fixation probability of mutants with s m Ͻ 0.

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Germline Bottlenecks, Biparental Inheritance and Selection on Mitochondrial Variants

2005

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“…Intraspecies cloning usually leads to generation of clonal embryos and resultant offspring in cattle (Steinborn et al, 1998a;Takeda et al, 1999Takeda et al, , 2003 and sheep (Evans et al, 1999), whose final composition of parental mitochondrial genome is established during preimplantation development. This is the result of a selective process involving predominant replacement of the exogenous mitochondrial genotype with mitochondrial haplotype of recipient cytoplast origin (Figure 3).…”

Section: Consequences Resulting From the Transmission Of Two Mitochonmentioning

confidence: 99%

The effect of mitochondrial genome on architectural remodeling and epigenetic reprogramming of donor cell nuclei in mammalian nuclear transfer-derived embryos

Samiec¹

2005

J. Anim. Feed Sci.

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There are some species-specific epigenetic factors present in the oocyte cytoplasm that may contribute to nucleo-cytoplasmic incompatibilities either immediately after nuclear transfer (NT) or at later stages of development. These potential incompatibilities will affect, to some degree, the ultimate utility of NT technology. It has been demonstrated that maternally inherited mitochondrial DNA molecules (mtDNAs) accumulated in the mitochondrial reservoirs of recipient-oocyte cytosol play an important role in nuclear-ooplasmic asynchrony. This asynchrony involves the incompatibility in epigenetic modifications of somatic genome supporting the developmental program of reconstituted cybrids. It also involves incompatibility in molecular mechanisms controlling the karyokinesis and cytokinesis restriction points responsible for coordinated pseudomeiotic to mitotic cycle transition following activation of the reconstituted oocyte. Moreover, the presence of oocyte-derived mitochondrial genetic apparatus influences clonal embryo implantation. For that reason, the deleterious effect on preimplantation development of NT embryos of heterogeneous mtDNA sources arising from possible mitochondrial heteroplasmy in the reconstructed nuclear-cytoplasmic hybrids, should not be discounted. That is why, the production of nuclear transfer embryos, foetuses and offspring with precisely defined constellations of nuclear and/or mitochondrial genome can be valuable for experimentally dissecting the effects of nuclear and cytoplasmic genetic/epigenetic components as well as the intrauterine environment on embryonic, foetal, and postnatal development of cloned individuals.

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“…John 2002). from both ECNT (Steinborn et al 1998a(Steinborn et al ,b, 2000 and SCNT (Hiendleder et al 1999;Takeda et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…observed in those offspring generated through both Since the first report of cloned ovine offspring genersomatic cell nuclear transfer (SCNT; Takeda et al 2003) ated from cultured embryonic cells (Campbell et al and embryonic cell nuclear transfer (ECNT; Steinborn 1996), NT has also been achieved using donor genetic et al 1998b, 2000). material from fetal and adult cell populations in a variety Embryonic cell NT offers the opportunity for further of species.…”

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“…For example, Figure 4E shows the nonspecificity of oocytes as recipients (Takeda et al 1999;Polejaeva et al 2000), which can result in the offspring being of the sperm primer to amplify the respective alleles associated with donor and recipient oocyte sources. cytoplasmically diverse (Takeda et al 1999(Takeda et al , 2003. This ultimately demonstrates the necessity to determine parRegulation of mtDNA transmission in nonhuman primates: To determine whether heteroplasmic transmission entage through both nDNA and mtDNA analysis.…”

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Paternal Mitochondrial DNA Transmission During Nonhuman Primate Nuclear Transfer

John

Schatten

2004

Genetics

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Offspring produced by nuclear transfer (NT) have identical nuclear DNA (nDNA). However, mitochondrial DNA (mtDNA) inheritance could vary considerably. In sheep, homoplasmy is maintained since mtDNA is transmitted from the oocyte (recipient) only. In contrast, cattle are heteroplasmic, harboring a predominance of recipient mtDNA along with varying levels of donor mtDNA. We show that the two nonhuman primate Macaca mulatta offspring born by NT have mtDNA from three sources: (1) maternal mtDNA from the recipient egg, (2) maternal mtDNA from the egg contributing to the donor blastomere, and (3) paternal mtDNA from the sperm that fertilized the egg from which the donor blastomere was isolated. The introduction of foreign mtDNA into reconstructed recipient eggs has also been demonstrated in mice through pronuclear injection and in humans through cytoplasmic transfer. The mitochondrial triplasmy following M. mulatta NT reported here forces concerns regarding the parental origins of mtDNA in clinically reconstructed eggs. In addition, mtDNA heteroplasmy might result in the embryonic stem cell lines generated for experimental and therapeutic purposes ("therapeutic cloning").

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Proliferation of donor mitochondrial DNA in nuclear transfer calves (Bos taurus) derived from cumulus cells

Cited by 83 publications

References 45 publications

Germline Bottlenecks, Biparental Inheritance and Selection on Mitochondrial Variants

Germline Bottlenecks, Biparental Inheritance and Selection on Mitochondrial Variants

The effect of mitochondrial genome on architectural remodeling and epigenetic reprogramming of donor cell nuclei in mammalian nuclear transfer-derived embryos

Paternal Mitochondrial DNA Transmission During Nonhuman Primate Nuclear Transfer

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