Proliferative diabetic retinopathy—The influence of diabetes control on the activation of the intraocular molecule system

Adamiec-Mroczek, Joanna; Oficjalska−Młyńczak, Jolanta; Misiuk-Hojło, Marta

doi:10.1016/j.diabres.2009.01.012

Cited by 37 publications

(28 citation statements)

References 15 publications

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“…Burgos et al demonstrated increases in vitreous concentration of VCAM-1 in PDR patients (26 ng/mL) compared to non-diabetic patients in whom a vitrectomy was performed (22 ng/mL) [104]. These results are also consistent with Mroczek et al in their study about the influence of glucose control on the activation of the intraocular molecular system [114].…”

Section: Vascular Cell Adhesion Molecule-1supporting

confidence: 69%

“…It is released by endothelial cells and is present as an early feature of inflammatory disease [111,113]. Several studies state that VCAM-1 promotes angiogenesis in PDR patients [105,[112][113][114]. Burgos et al demonstrated increases in vitreous concentration of VCAM-1 in PDR patients (26 ng/mL) compared to non-diabetic patients in whom a vitrectomy was performed (22 ng/mL) [104].…”

Section: Vascular Cell Adhesion Molecule-1mentioning

confidence: 99%

“…Oxidative stress, VEGF, and hypercholesterolemia increase the expression of VCAM-1 in the brain and retina [111,113,114]. It is released by endothelial cells and is present as an early feature of inflammatory disease [111,113].…”

Section: Vascular Cell Adhesion Molecule-1mentioning

confidence: 99%

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Proliferative Diabetic Retinopathy: An Overview of Vitreous Immune and Biomarkers

Victor¹,

Sitompul²

2018

Early Events in Diabetic Retinopathy and Intervention Strategies

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This chapter discusses about the effect of vitreous immune system and biomarkers on the progression of proliferative diabetic retinopathy. Immune system and biomarkers have been believed to have an important role in the progression of diabetic retinopathy (DR) severity. Hyperglycemic will influence immune cells resulting in chronic inflammation on the retina. This condition progressively disrupts the blood-retinal barrier in retina causing those inflammatory molecules and immune cells to transfer from circulation. The transfer of these molecules plays an important part in the progression of proliferative diabetic retinopathy. In addition, biomarkers are indicators for some complex processes happened in our body, and are measured to determine diagnosis and prognosis of some treatment. There are several biomarkers that have been identified in DR patients including biomarkers of oxidative stress, hypoxia-inducible factors, angiogenic factors, pro-inflammatory cytokines, chemokines, cell adhesion molecules, and soluble CD200. The value of these biomarkers will tell us their possible role in the progression of DR. By improving the knowledge of molecular pathway in DR pathophysiology, the advancement of selective therapy approaches could be discovered and the management of DR could be more efficient.

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Section: Vascular Cell Adhesion Molecule-1supporting

confidence: 69%

Section: Vascular Cell Adhesion Molecule-1mentioning

confidence: 99%

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Proliferative Diabetic Retinopathy: An Overview of Vitreous Immune and Biomarkers

Victor¹,

Sitompul²

2018

Early Events in Diabetic Retinopathy and Intervention Strategies

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“…When interpreting these results, the following issues should be taken into consideration. First, ICAM-1 regulates the migration of white blood cells to the inflammatory sites and destroys the blood-retinal barrier by interacting with a variety of cytokines, and leucocytes accumulate in the capillaries to form embolus, block the capillaries and release a variety of active substances, and induce the pathological changes of DR. For example, the elevated levels of ICAM-1 in serum and vitreous have been found in PDR by Adamiec-Mroczek et al 33. Second, vascular endothelial growth factor, a molecule closely related to the pathogenesis of retinopathy, can trigger early retinal inflammation by inducing the expression and upregulation of sICAM-1.…”

Section: Discussionmentioning

confidence: 95%

Association between ICAM-1 level and diabetic retinopathy: a review and meta-analysis

Yao

et al. 2019

Postgraduate Medical Journal

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Elevated levels of proinflammatory markers are evident in patients with diabetic retinopathy (DR) and are associated with disease progression and prognosis. Intercellular adhesion molecule-1 (ICAM-1) is involved in inflammation and acts as a local intensifying signal in the pathological processes associated with chronic eye inflammation. The aim of this systematic review and meta-analysis was to investigate the relationship between ICAM-1 level and DR. Online electronic databases were searched to retrieve all relevant articles published before December 2017. The standard mean difference (SMD) and their 95% CI were included and then pooled with a random effects model. Subgroup analysis and metaregression analysis were applied to explore the sources of heterogeneity, and publication bias was calculated to assess the quality of pooled studies. A total of 11 articles, containing 428 patients with DR and 789 healthy controls, were included in this meta-analysis. The results indicated a significant increase in ICAM-1 level in the DR group compared with the control group (SMD: 1.20, 95%CI 0.83 to 1.57, p<0.001). Subgroup analyses and metaregression analysis indicated that publication year, region, study method, diabetes mellitus type, Newcastle-Ottawa Scale and sample size were not the potential sources of heterogeneity. The results of this current meta-analysis indicated that the increased level of ICAM-1 generally exists in the patients with DR and it may associated with the severity of DR. However, large-scale and high-quality studies are required to confirm this finding in the future.

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“…3,4 Increased ICAM-1, vascular cell adhesion molecule-1, and e-selectin levels were found in the serum from patients with diabetic microangiopathy. [5][6][7] In diabetic animal models, increased retinal ICAM-1 expression is believed to be responsible for leukocyte adhesion or leukostasis and increased vascular permeability. Leukostasis is believed to contribute to capillary nonperfusion and local ischemia, which subsequently induces the overexpression of vascular endothelial growth factor (VEGF).…”

mentioning

confidence: 99%

Activation of the Wnt Pathway Plays a Pathogenic Role in Diabetic Retinopathy in Humans and Animal Models

Chen

Zhou

et al. 2009

The American Journal of Pathology

134

189

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Although Wnt signaling is known to mediate multiple biological and pathological processes, its association with diabetic retinopathy (DR) has not been established. Here we show that retinal levels and nuclear translocation of ␤-catenin, a key effector in the canonical Wnt pathway, were increased in humans with DR and in three DR models. Retinal levels of lowdensity lipoprotein receptor-related proteins 5 and 6, coreceptors of Wnts , were also elevated in the DR models. The high glucose-induced activation of ␤-catenin was attenuated by aminoguanidine, suggesting that oxidative stress is a direct cause for the Wnt pathway activation in diabetes. Indeed, Dickkopf homolog 1, a specific inhibitor of the Wnt pathway, ameliorated retinal inflammation, vascular leakage, and retinal neovascularization in the DR models. Dickkopf homolog 1 also blocked the generation of reactive oxygen species induced by high glucose, suggesting that Wnt signaling contributes to the oxidative stress in diabetes. These observations indicate that the Wnt pathway plays a pathogenic role in DR and represents a novel therapeutic target. Diabetic retinopathy (DR), the leading cause of blindness in the working age population, represents a common concern in types 1 and 2 of diabetes mellitus (DM). 1 Accumulating evidence suggests that DR is a chronic inflammatory disorder.2 Retinal inflammation is believed to play a causative role in vascular leakage, which can lead to diabetic macular edema, and in retinal neovascularization (NV). It has been shown that levels of soluble intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 are significantly higher in the vitreous from patients with proliferative diabetic retinopathy than in nondiabetic vitreous. 3,4 Increased ICAM-1, vascular cell adhesion molecule-1, and e-selectin levels were found in the serum from patients with diabetic microangiopathy. [5][6][7] In diabetic animal models, increased retinal ICAM-1 expression is believed to be responsible for leukocyte adhesion or leukostasis and increased vascular permeability. Leukostasis is believed to contribute to capillary nonperfusion and local ischemia, which subsequently induces the overexpression of vascular endothelial growth factor (VEGF). 8 -11 Increased VEGF levels are responsible for the retinal vascular leakage and retinal NV.12,13 Recent studies have indicated that oxidative stress, induced by hyperglycemia, contributes to retinal inflammation in diabetes.14,15 However, the pathogenic mechanisms by which diabetes and oxidative stress induce inflammation are not certain at the present time.Wnts are a group of secreted, cysteine-rich glycoproteins, which bind to a coreceptor complex of frizzled (Fz) receptors and low-density lipoprotein receptor-related protein 5 or 6 (LRP5/6) and regulate expression of a number of target genes through an intracellular signaling pathway, namely the Wnt pathway. 16 In the absence of Wnt ligands, ␤-catenin, a down-stream effector of the canonical Wnt pathway, is phosphorylated by a pro...

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Proliferative diabetic retinopathy—The influence of diabetes control on the activation of the intraocular molecule system

Cited by 37 publications

References 15 publications

Proliferative Diabetic Retinopathy: An Overview of Vitreous Immune and Biomarkers

Proliferative Diabetic Retinopathy: An Overview of Vitreous Immune and Biomarkers

Association between ICAM-1 level and diabetic retinopathy: a review and meta-analysis

Activation of the Wnt Pathway Plays a Pathogenic Role in Diabetic Retinopathy in Humans and Animal Models

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