Proliferative Verrucous Leukoplakia and Verrucous Hyperplasia

Murrah, Valerie A.; Batsakis, John G.

doi:10.1177/000348949410300816

Cited by 90 publications

(63 citation statements)

References 10 publications

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“…In the present series, male to female ratio was 6:4. The age with VC of oral cavity is reported to be high [4][5][6][7][8][9], as was the case of the present series. The presenting symptoms have not been reported in the literature.…”

Section: Discussionsupporting

confidence: 63%

“…VCs of the present series are different from verrucous hyperplasia, proliferative verrucous leukoplakia, and well differentiated papillary squamous cell carcinoma from the standpoints of histology and immunohistochemistry [9]. The cases of the present series are not verrucous leukoplakia, a premalignant condition having a capacity to transform into squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 53%

“…This entity had less atypia than VC. In addition, verrucous leukoplakia was not so verrucous, and was more superficial to the surrounding squamous epithelium [9].…”

Section: Discussionmentioning

confidence: 91%

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Verrucous Carcinoma of the Oral Cavity: A Histopathologic Study of 10 Japanese Cases

Terada

2011

J. Maxillofac. Oral Surg.

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Objective To reports ten Japanese surgical cases of verrucous carcinoma (VC) of the oral cavity. Study design The author reviewed histopathology of 10 cases of oral VC. Results Ten cases of oral VC were found in our pathology department in the last 10 years. During the 10 years, a total of 187 cases of oral malignancy were recognized. Therefore, the frequency of VC was 5.3% of all oral malignancies. The patients consisted of six women and four men. The age ranged from 52 to 84 years with a median of 68 years. The locations of VC were buccal mucosa in two cases, gingiva in three cases, hard palate in one case, tongue in three cases, and soft palate in one case. The presenting symptoms were oral discomfort in two cases and tumors in eight cases. All cases underwent surgical resection. Frozen sections were performed in three cases for margin check. Grossly, all cases showed verrucous lesions. The size ranged from 0.8 to 3.2 cm with a median of 1.3 cm. Histologically, tumor cells proliferated with verrucous or papillary features. The tumor cells had acidophilic, ample cytoplasm, and nuclear atypia was minimal. Individual keratinization, koilocytosis, basal cell mild atypia, and squamous pearl formation were recognized in all cases. Three cases showed microinvasion. One case had focal ordinary squamous cell carcinoma within the VC. Epithelial dysplasia in the mucosa was recognized in the vicinity of VC in two cases. One case showed multiple tumors of VC; the number was five. Lymphocytic infiltration in the dermis was recognized in seven cases. Immunohistochemically, p53 protein was positive in all the ten cases. Its location was accentuated near the basal cells and microinvasive parts. Ki-67 positive cells were also seen mainly in the basal cells and in the microinvasive areas, and the KI-67 labeling index ranged from 12 to 21%. Two patients recurred, and additional operations were performed. None show metastatic lesions. One patient died of other disease, and nine patients are now alive without tumors. Conclusion Clinicopathologic features of ten cases of oral VC were described.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 53%

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Verrucous Carcinoma of the Oral Cavity: A Histopathologic Study of 10 Japanese Cases

Terada

2011

J. Maxillofac. Oral Surg.

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“…The histology of the present tumors fulfills the criteria of VC. VCs of the present case are different from verrucous hyperplasia, proliferative verrucous leukoplakia, and well differentiated papillary squamous cell carcinoma with regard to the histology and immunohistochemistry [12]. Verrucous hyperplasia and verrucous leukoplakia are not true neoplasms and do not show florid verrucous proliferation as seen in the present case.…”

Section: Discussioncontrasting

confidence: 60%

Multiple Verrucous Carcinomas of the Oral Cavity

Terada

2014

J. Maxillofac. Oral Surg.

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The author herein reports a case of multiple verrucous carcinomas (VCs) of the left lower gingiva. A 78-year-old man was admitted to our hospital because of gingival tumor. A biopsy revealed severe dysplasia. Surgical resection was performed. Grossly, there were three verrucous lesions (25, 20, 10 mm) in the left lower gingiva. Histologically, 2 tumors (4, 2 mm) were found in addition to the grossly visible 3 tumors. All the 5 tumors were VCs. The tumors showed verrucous and papillary proliferation of squamous epithelium with little cellular atypia. No invasive features were recognized. The dermis showed lymphocytic infiltration. The surrounding mucosa showed many broad foci of squamous cell carcinoma in situ and severe dysplasia (high grade intraepithelial neoplasm). Gradual merges between the VCs and squamous cell carcinoma in situ or severe dysplasia were frequently recognized. Immunohistochemically, the VC tumor cells and squamous lesions were negative for human papilloma virus antigens. P53 protein was expressed in all the VCs and squamous epithelial lesions: it was accentuated in the basal and suprabasal cells of VC. Ki-67 antigen was also expressed in the 5 VCs and in the squamous lesion, and Ki-67 labeling index ranged from 8 to 16 % in VC and from 37 to 62 % in the squamous lesions. These data support the multicentric nature of VC and that the severe dysplasiacarcinoma in situ sequence have been proposed in the etiology of VC.

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“…Males are more affected than women, 2:1. The therapy, based on the onset place and stage, can be divided in surgery, chemiotherapy, radiotherapy or a combination of these actions (3)(4)(5). The resections of these tumors can produce defects of the oral and nasal cavities, nasopharynx, oropharynx and extra-oral defects.…”

Section: Introductionmentioning

confidence: 99%

Prosthetic Management of Patients With Oro-Maxillo-Facial Defects: A Long-Term Follow-Up Retrospective Study

Gastaldi

Palumbo

Moreschi

et al. 2017

ORL

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SUMMARYIntroduction. The aim of this study is to determine the outcome of maxillofacial prosthetic rehabilitation after oncological resections, including both intra-and extra-oral prosthetic devices. Methods. In this study were included 72 patients, who have undergone an intra or extra-oral maxillofacial prosthetic rehabilitation after an oncologic resection. Tumors on the head and neck were analyzed and the defects of these resections have been divided in two different groups: intra and extra-oral defects. Results. 72 participants were treated with maxillofacial prosthesis, 3 of which with post-traumatic wounds and 69 with resections of tumors on the head and neck. Of the 69 treated for neoplastic disease, 43 received an intraoral prosthesis (palatal obturator) and 29 with an extraoral epithesis (18 with nasal prostheses, 8 with orbital implants and 3 with ear implants).The group included patients with different types of tumors. All the patients were evaluated in terms of aesthetic appearance after the construction of the prostheses and the results were satisfactory. Conclusion. Within the limitations of this study, after the use of maxillofacial protheses patients feel more confident and self-assured. Maxillofacial protheses are a good solution in order to improve the life's quality in patients with tumors resections: prostheses are easy to handle and provide a satisfying social interaction for the patients.

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Proliferative Verrucous Leukoplakia and Verrucous Hyperplasia

Cited by 90 publications

References 10 publications

Verrucous Carcinoma of the Oral Cavity: A Histopathologic Study of 10 Japanese Cases

Verrucous Carcinoma of the Oral Cavity: A Histopathologic Study of 10 Japanese Cases

Multiple Verrucous Carcinomas of the Oral Cavity

Prosthetic Management of Patients With Oro-Maxillo-Facial Defects: A Long-Term Follow-Up Retrospective Study

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