1975
DOI: 10.1016/0304-4165(75)90241-x
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Proline recycling during collagen metabolism as determined by concurrent 18O2- and 3H-labeling

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Cited by 79 publications
(33 citation statements)
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“…General Collagen Synthesis-The mean hydroxyproline level in posterior scleral extracts of control eyes in the present study was 59.7 Ϯ 3.5 g, which we estimate represents ϳ40% of the collagen present, assuming a collagen hydroxyproline content of 10% and a scleral collagen content of 90% (11,40). This finding is in keeping with a previous report in corneal tissue (34).…”
Section: Ocularsupporting
confidence: 92%
“…General Collagen Synthesis-The mean hydroxyproline level in posterior scleral extracts of control eyes in the present study was 59.7 Ϯ 3.5 g, which we estimate represents ϳ40% of the collagen present, assuming a collagen hydroxyproline content of 10% and a scleral collagen content of 90% (11,40). This finding is in keeping with a previous report in corneal tissue (34).…”
Section: Ocularsupporting
confidence: 92%
“…3.4.13.9) is a ubiquitous cytosolic enzyme involved in the deactivation of neuropeptides (Hui and Lajtha 1980), in the facilitation of renal excretion of hydroxyproline and excess of proline (Jackson and Heininger 1975) and in the latter stage of both dietary and endogenous protein catabolism (Myara et al 1984). It specifically cleaves iminodipeptides containing Cterminal prolyl or hydroxyprolyl residues thus playing an important role in the final stage of degradation of collagen, which is particularly rich in those amino acids.…”
Section: Introductionmentioning
confidence: 99%
“…Its putative biologic roles include the deactivation of neuropeptides (1), the terminal degradation in the catabolic pathway of both exogenous and endogenous proteins, and providing large amounts of proline required for collagen synthesis. It also is thought to play an important role in proline nutrition and in the recycling of proline for protein synthesis and cell growth (2,3). Prolidase may also provide the substrate for proline oxidase, which generates reactive oxygen species during apoptosis (4,5).…”
mentioning
confidence: 99%