Prolongation of Postoperative Disease-Free Interval and Survival in Human Colorectal Cancer by B.C.G. Or B.C.G. Plus 5-Fluorouracil

Mavligit, Giora M.; Burgess, Michael A.; Seibert, G. Burton; Jubert, Andre V.; McBride, Charles M.; Gehan, Edmund A.; Gutterman, Jordan U.; Khankhanian, Nayerh; Speer, John F.; Martin, Richard C.; Copeland, Edward M.; Hersh, Evan M.

doi:10.1016/s0140-6736(76)92093-6

Cited by 85 publications

(14 citation statements)

References 38 publications

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“…At the present time, a few trials of immunotherapy of human intestinal cancer have been reported (Moertel et al, 1975;Falk et al, 1976;Mavligit et al, 1976). They were not conclusive, mainly because the patients were not randomised before being entered in the trial.…”

Section: Discussionmentioning

confidence: 97%

Immunoprophylaxis and therapy of grafted rat colonic carcinoma.

Martin¹,

Martin²,

Justrabo³

et al. 1977

Gut

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SUMMARY Two independent lines of chemically-induced colonic carcinoma, serially graftable in syngeneic rats, have been used to investigate the effects of immunoprophylaxis and immunotherapy. Rats were immunised by various procedures, including BCG, irradiated tumour grafts, and cancer cells treated by mitomycin and neuraminidase. A partial inhibition of tumour growth was observed in one of the four tested protocols. On the other hand, a significant enhancement of tumour growth was obtained in two other experiments.Patients with colon carcinoma have been shown to react immunologically against tumour-associated antigens (Hellstrom et al., 1970;Hollinshead et al., 1970;. This finding suggests the use of immunotherapy to secure the surgical cure of this tumour. Demonstration of the objective effects of immunotherapy and the choice of the most efficient method require prolonged study in humans, because of the slow evolution of colorectal cancer. For this reason, we have chosen an animal model of chemically-induced colonic cancer (Martin et al., 1973a). The following report deals with our preliminary attempts to treat rat colonic cancer by specific or non-specific immunological treatment. Methods ANIMALSAll rats were of the inbred BD-IX strain, maintained by continuous brother-sister mating. Inbreeding has been confirmed by permanent acceptance of skin grafts. TUMOURSTwo serially graftable tumour lines, DHB and DHD, were independently obtained from colonic adenocarcinomas induced by 1,2 dimethylhydrazine (Martin et al., 1973b

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Section: Discussionmentioning

confidence: 97%

Immunoprophylaxis and therapy of grafted rat colonic carcinoma.

Martin¹,

Martin²,

Justrabo³

et al. 1977

Gut

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“…For comparison we have grouped our patients into four stages of treatment: (1) 'presurgery': 2-3 days before tumor resection; (2) 'postsurgery': 14 days after tumor resection, before any other therapy was initiated; (3) 'without therapy': more than 3 months after tumor resection and without any further therapy, and (4) 'under therapy': more than 3 months after tumor resection and still being treated by chemo-immunotherapy [24], Before calculation of the mean value in each clinical stage group, the individual polyamine values obtained were statistically sieved from outliers [25]. Statistical comparison was thereafter calculated with the aid of the Student t test.…”

Section: Sample Preparationmentioning

confidence: 99%

Rapid Detection of Polyamines in the Sera of Patients with Colorectal Carcinoma by Liquid Ion-Exchange Chromatography

Desser¹,

D²,

Krieger³

et al. 1980

Oncology

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The polyamines spermidine and spermine and the diamines putrescine and cadaverine have been determined in their free and unbound state in the sera of patients with colorectal carcinoma. The obtained values were compared with normal control levels. Elevated levels of putrescine and spermidine were found in untreated patients and declined to the control range after surgical and chemotherapeutic treatment. Spermine levels remained unchanged throughout the observation at normal control levels.

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“…In an effort to improve these figures, primary surgical treatment has been combined with adjuvant irradiation and /or chemotherapy . An interim report of a clinical trial of adjuvant immunotherapy fo llowing surgery for Dukes' C colo-rectal carcinoma lias appeared (IV) (76). The adjuvant therapy group (83 patients) was randomized to receive long-term 5-Fluorouracil (5-FU) plus intra dermal BCG (50 patients), or long-term intradermal BCG only (33 patients These groups were compared to historical controls treated by surgery alone at the M. D. Anderson Hospital and Tumor Institute in Houston, Texas (73 patients) .…”

Section: Colo-rectal Carcinoma and Other Gastrointestinal Tumorsmentioning

confidence: 99%