Prolonged action of drugs in rats with flavonoid-deficiency

Seidel, G.; Endell, W

doi:10.1007/bf02034708

Cited by 4 publications

(1 citation statement)

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“…The influence of the certain herbal BAS on thiopentalinduced narcosis course is not sufficiently studied (as it is with ethanol-induced narcosis), complicating analysis of GW phytopharmacological properties. It is unlikely that flavonoids are involved in counteraction of GW to hypnotic effect, as some of flavonoid glycosides (at intraperitoneal administration) are, on the contrary, able to potentiate barbiturate-induced sleep [17], and in rats with flavonoid-deficiency its duration decreases [22].…”

Section: Fig 2 the Influence Of Goutweed Preparations On Ethanol-inmentioning

confidence: 99%

Interaction of Aegopodium podagraria L. (goutweed) preparations with central nervous system depressants

Tovchiga

2016

Ukr. bìofarm. ž.

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This study addressed the influence of Aegopodium podagraria L. (goutweed) aerial part extract (100 mg/kg and 1 g/kg) and tincture (1 and 5 ml/kg) on the course of ethanol-induced as well as thiopental sodium induced narcosis. It has been shown that the extract at a dose of 1 g/kg, but not 100 mg/kg, significantly reduces the duration of ethanol-induced narcosis in male mice, the extract at a low dose decreases the onset of the loss of righting reflex. The tincture does not influence on the course of ethanol-induced narcosis, but significantly reduces the duration of sleep caused by thiopental sodium in male mice (at a dose of 1 ml/kg, but not 5 ml/kg), by this effect it is comparable with Hypericum perforatum L. extract at a dose of 100 mg/kg. Goutweed extract does not influence on the duration of thiopental-induced sleep.

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Section: Fig 2 the Influence Of Goutweed Preparations On Ethanol-inmentioning

confidence: 99%