Prolonged Diarrhea Due to Ciprofloxacin‐Resistant<i>Campylobacter</i>Infection

Nelson, Jennifer; Smith, Kirk E.; Vugia, Duc J.; Rabatsky‐Ehr, Therese; Segler, Suzanne; Kassenborg, Heidi; Zansky, Shelley; Joyce, Kevin; Marano, Nina; Hoekstra, Robert M.; Angulo, Frederick J.

doi:10.1086/423282

Cited by 137 publications

(92 citation statements)

References 21 publications

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“…The levels of MDR strains in humans are still relatively low overall (Ͻ25%) (286), but an increase in these strains in domesticated animals has raised concerns in relation to human disease (287). These concerns are well placed given that infections with Campylobacter species which are resistant to antibiotics have been associated with a longer duration of illness, an increased risk of invasive disease and death, and increased health care costs (288)(289)(290). In the case of severe Campylobacter infection in humans, treatment with aminoglycosides (e.g., gentamicin or kanamycin) is commonly employed (291).…”

Section: Antibiotic Therapiesmentioning

confidence: 99%

Global Epidemiology of Campylobacter Infection

et al. 2015

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SUMMARY Campylobacter jejuni infection is one of the most widespread infectious diseases of the last century. The incidence and prevalence of campylobacteriosis have increased in both developed and developing countries over the last 10 years. The dramatic increase in North America, Europe, and Australia is alarming, and data from parts of Africa, Asia, and the Middle East indicate that campylobacteriosis is endemic in these areas, especially in children. In addition to C. jejuni , there is increasing recognition of the clinical importance of emerging Campylobacter species, including Campylobacter concisus and Campylobacter ureolyticus . Poultry is a major reservoir and source of transmission of campylobacteriosis to humans. Other risk factors include consumption of animal products and water, contact with animals, and international travel. Strategic implementation of multifaceted biocontrol measures to reduce the transmission of this group of pathogens is paramount for public health. Overall, campylobacteriosis is still one of the most important infectious diseases that is likely to challenge global health in the years to come. This review provides a comprehensive overview of the global epidemiology, transmission, and clinical relevance of Campylobacter infection.

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Section: Antibiotic Therapiesmentioning

confidence: 99%

Global Epidemiology of Campylobacter Infection

et al. 2015

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“…Gupta et al [30] reported 31% patients with ciprofloxacin-resistant Campylobacter were hospitalized for gastroenteritis compared to 3% patients with sensitive strains. In a case control study carried out in 1998-1999 in 290 patients who did not take anti-diarrheal medication for campylobacteriosis, those with ciprofloxacin-resistant strains had a mean duration of diarrhea of 9 days, compared to 7 days in those with sensitive isolates [31]. Of 85 persons who took fluoroquinolone antimicrobials only, diarrhea lasted a mean of 8 days in those with resistant strains but 6 days in those with sensitive isolates.…”

Section: Although 14 Campylobacter Species Have Been Identified In Tmentioning

confidence: 99%

Low Prevalence of Campylobacteriosis in the Northern Region of India

Vaishnavi¹,

Singh²,

Thakur³

et al. 2015

AiM

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Campylobacter is one of the most common bacterial enteropathogens of food borne origin in industrialized countries with C. jejuni being the most common species followed by C. coli. The prevalence of Campylobacters in and around Chandigarh, India was studied by phenotypic and genotypic methods. Fecal samples from 1145 diarrheal patients and 102 healthy subjects from hospital and community were cultured on Campylobacter media and identified by Gram stain, biochemical investigations and serotyping. Molecular identification of Campylobacter isolates was done using specific primers to unique regions of 16S rRNA, Campylobacter jejuni (hipO), Campylobacter coli (aspK), Campylobacter lari (glyA) and Campylobacter upsaliensis (lpxA) genes. Identification of specific genes to look for resistance to nalidixic acid, ciprofloxacin, tetracyclin and streptomycin was also done. Campylobacters were isolated from 2.6% of patients with diarrhea. Campylobacteriosis was more prevalent in children ≤5 years old and during summer season. The most frequent serotypes were S:27, B:2, Z5:52 and V:32. All the Campylobacters isolated by culture were confirmed genotypically by identification of 16S rRNA, hipO and aspK genes. Of the 30 isolates, 27 were C. jejuni and 3 were C. coli. No C. lari or C. upsaliensis were detected. Antibiotic resistance was 40% for nalidixic acid, 23.3% for ciprofloxacin, 50% for tetracyclin and 20% for streptomycin. Campylobacter prevalence is low in the region with C. jejuni being the most common species. A high degree of resistance was found for nalidixic acid and tetracyclin but moderate for ciprofloxacin and streptomycin.

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“…Examples include those provided by (CSSSC, 2002;Engberg, J et al, 2004;Johnson, JY et al, 2008;Nelson, JM et al, 2004;Smith, KE et al, 1999). All of these case-control studies identified foreign travel as a risk factor for acquisition of a FQ-resistant campylobacter infection.…”

Section: 5mentioning

confidence: 99%

Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections

2009

EFSA Journal

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Prolonged Diarrhea Due to Ciprofloxacin‐ResistantCampylobacterInfection

Abstract: Persons with ciprofloxacin-resistant Campylobacter infection have a longer duration of diarrhea than do persons with ciprofloxacin-susceptible Campylobacter infection. Additional efforts are needed to preserve the efficacy of fluoroquinolones.

Cited by 137 publications

References 21 publications

Global Epidemiology of Campylobacter Infection

Global Epidemiology of Campylobacter Infection

Low Prevalence of Campylobacteriosis in the Northern Region of India

Joint Opinion on antimicrobial resistance (AMR) focused on zoonotic infections

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