Prolonged exposure of di(2-ethylhexyl) phthalate induces multigenerational toxic effects in Caenorhabditis elegans

Li, Shangwei; How, Chun Ming; Liao, Vivian Hsiu‐Chuan

doi:10.1016/j.scitotenv.2018.03.355

Cited by 49 publications

(11 citation statements)

References 33 publications

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“…These effects of exposure to the mixture of phthalates were observed in the second and third generation of the progeny of mice [ 131 ]. The similar results occurred in the progeny of Caenorhabditis elegans after the prenatal exposure to DEHP at 20 mg/L [ 133 ]. Therefore, we can assume that phthalate exposure has a transgenerational as well as a multigenerational effect on fertility in female animal models [ 131 ].…”

Section: Phthalates’ Action On Female Reproductive Healthsupporting

confidence: 69%

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Hlisníková

Petrovičová

Kolena

et al. 2020

IJERPH

164

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The production of plastic products, which requires phthalate plasticizers, has resulted in the problems for human health, especially that of reproductive health. Phthalate exposure can induce reproductive disorders at various regulatory levels. The aim of this review was to compile the evidence concerning the association between phthalates and reproductive diseases, phthalates-induced reproductive disorders, and their possible endocrine and intracellular mechanisms. Phthalates may induce alterations in puberty, the development of testicular dysgenesis syndrome, cancer, and fertility disorders in both males and females. At the hormonal level, phthalates can modify the release of hypothalamic, pituitary, and peripheral hormones. At the intracellular level, phthalates can interfere with nuclear receptors, membrane receptors, intracellular signaling pathways, and modulate gene expression associated with reproduction. To understand and to treat the adverse effects of phthalates on human health, it is essential to expand the current knowledge concerning their mechanism of action in the organism.

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Section: Phthalates’ Action On Female Reproductive Healthsupporting

confidence: 69%

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Hlisníková

Petrovičová

Kolena

et al. 2020

IJERPH

164

View full text Add to dashboard Cite

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“…This assumption was confirmed by the observed damage on gonad development which was reflected by the length of the gonad arm, no eggs or vulva, abnormal oocytes, abnormal uterus, and relative area of the gonad arm after exposure to pollutants (Kim et al, 2013; Moon et al, 2017; Sun, Liao, et al, 2021). This assumption was also confirmed by the observations of elevated germline cell apoptosis, inadequate vitellogenin production, and slow germline proliferation in both P0 generation and subsequent descendant after exposure to pollutants (Li et al, 2018; Lu et al, 2020; Sun, Liao, et al, 2021; Yu et al, 2021).…”

Section: The Underlying Mechanisms For Transgenerational and Multigen...mentioning

confidence: 64%

“…As shown in Table 1, exposure to metals, organics, particle matters, and nanomaterials usually causes the reproductive toxicity reflecting by decreased offspring, prolonged generation time, and reproductive system abnormalities (such as impaired vulva development and retarded gonadal development) at both the P0 generation and the subsequent generations (Hu et al, 2008; Lu et al, 2020; Wang, Xie, et al, 2007). Inadequate vitellogenin production, BOW (bag of worms) phenotype, no eggs, increased germline apoptosis, and germline DNA damage were also detected in both the exposed P0 generation and the non‐exposed subsequent generations (Kim et al, 2013; Li et al, 2018; Lu et al, 2020). Generally, the brood sizes were decreased in P0 and F1, but some pollutants even reduced the brood size in F3 to F5 generations (Yu & Liao, 2016).…”

Section: Transgenerational Toxicity Induction Of Pollutantsmentioning

confidence: 99%

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A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans

Zhao

Chen

Wang

et al. 2022

J of Applied Toxicology

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A large number of pollutants existing in the environment can last for a long time, and their potential toxic effects can transfer from parents to their offspring. Thus, it is necessary to investigate the toxicity of environmental pollutants across multigenerations and the underlying mechanisms in organisms. Due to its short life cycle and sensitivity to environmental exposures, Caenorhabditis elegans is an important animal model for toxicity assessment of environmental pollutants across multigenerations. In this review, we introduced the transgenerational and multigenerational toxicity caused by various environmental pollutants in C. elegans. Moreover, we discussed the underlying mechanisms for the observed transgenerational and multigenerational toxicity of environmental contaminants in C. elegans.

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“…Then the body length of C. elegans was measured under an Olympus SZX10 stereomicroscope. Locomotion assays were determined following Li et al 26 After exposure, the wild‐type N2 nematodes were washed with M9 buffer and then placed on new NGM plates. After 1 min recovery, the frequency of head thrashes and body bends within 30 s was counted under a stereomicroscope.…”

Section: Methodsmentioning

confidence: 99%

Exposure to fluopimomide at sublethal doses causes oxidative stress in Caenorhabditis elegans regulated by insulin/insulin‐like growth factor 1‐like signaling pathway

Zhang

Liu

et al. 2022

Environmental Toxicology

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Fluopimomide is an innovative pesticide, widely used for agricultural pest management; however, little is known about its effect on non‐target organisms. This study was designed to assess the potential risk of fluopimomide and the molecular mechanisms using Caenorhabditis elegans, a common model animal. The oxidative stress‐related indicators were analyzed in C. elegans after exposure to fluopimomide for 24 h at three sublethal doses (0.2, 1.0, and 5.0 mg/L). The results demonstrated that sublethal exposure to fluopimomide adversely affected the nematodes growth, locomotive behaviors, reproduction, and lifespan, accompanying with enhanced of reactive oxygen species (ROS) generation, lipid and lipofuscin accumulation, and malondialdehyde content. In addition, exposure to fluopimomide significantly inhibited antioxidant systems including superoxide dismutase, catalase, glutathione S‐transferase, and glutathione in the nematodes. Moreover, the expression of oxidative stress‐related genes of sod‐3, hsp‐16.1, gst‐4, ctl‐2, daf‐16, and daf‐2 were significantly down‐regulated, while the expression of skn‐1 was significantly up‐regulated. Further evidence revealed that daf‐16 and skn‐1 mutant strains of C. elegans significantly decreased ROS production upon fluopimomide exposure compared with the wild‐type nematodes. Overall, our findings indicated that exposure to fluopimomide at sublethal doses caused oxidative damage, mainly associated with insulin/IGF‐1‐like signaling pathway in C. elegans. This is the first report of potential toxic effects of fluopimomide even at low concentrations, providing a new insight into the mechanisms of toxicity to C. elegans by fluopimomide.

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Prolonged exposure of di(2-ethylhexyl) phthalate induces multigenerational toxic effects in Caenorhabditis elegans

Cited by 49 publications

References 33 publications

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

A review of transgenerational and multigenerational toxicology in the in vivo model animal Caenorhabditis elegans

Exposure to fluopimomide at sublethal doses causes oxidative stress in Caenorhabditis elegans regulated by insulin/insulin‐like growth factor 1‐like signaling pathway

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