Prolonged Rupture of Membranes, Neonatal Outcomes and Management Guidelines

Al-lawama, Manar; AlZaatreh, Ala; Elrajabi, Rawan; Abdelhamid, Sultan; Badran, Eman

doi:10.14740/jocmr3809

Cited by 29 publications

(26 citation statements)

References 23 publications

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“…Regarding the association between caesarean delivery and neonatal sepsis, reported results vary and depend on the analysed population. In a retrospective study by Al-Lawama et al [29] authors analysed sepsis risk factors among patients with rupture of membranes after completed 34 th gestational week. Mode of delivery in the 176 analysed patients was not significant: 16 (50%) of newborns with sepsis and 65 (45%) controls were delivered via c-section, p = 0.62.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with neonatal infectious and respiratory morbidity following preterm premature rupture of membranes

et al. 2022

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Objectives: Preterm premature rupture of membranes (pPROM) is associated with the increased risk of chorioamnionitis, foetal exposure to inflammation, and respiratory complications in preterm neonates. The aim of the study was to identify patients at highest risk of developing neonatal infectious and respiratory morbidity following pPROM and preterm birth. Material and methods:It was a retrospective cohort study including 299 consecutive patients in singleton pregnancies complicated by preterm premature rupture of membranes and giving birth between 22 nd and 36 th gestational week. Analysed factors included maternal characteristics, obstetric history, gestational age at pPROM and at delivery, latency and management. Multivariate logistic regression models were applied in order to identify risk factors for severe infectious and respiratory neonatal complications. Results:Earlier gestational age at pPROM is associated with increased probability of developing early-onset neonatal sepsis and pulmonary hypertension. Earlier gestational age at birth and lower birth weight were independent factors associated with neonatal respiratory distress syndrome. Positive cervical culture was identified as a risk factor for acute neonatal respiratory failure.Conclusions: Gestational age at pPROM, gestational age at birth and birth weight were the leading factors influencing the risk of developing neonatal infectious and respiratory morbidity following preterm premature rupture of membranes.

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Section: Discussionmentioning

confidence: 99%

Risk factors associated with neonatal infectious and respiratory morbidity following preterm premature rupture of membranes

et al. 2022

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“…The most common maternal risk factor associated with neonatal sepsis was PROM (16.7% cases and 1.7% controls). PROM is a significant risk factor for early onset neonatal sepsis 22 with higher Odds of neonatal sepsis in neonates of mothers with PROM. 23 The longer the duration of ruptured membranes, the higher the risk of sepsis.…”

Section: Discussionmentioning

confidence: 99%

Role of Maternal Risk Factors and Neonatal Clinical Features in Diagnosis of Neonatal Sepsis: A Case Control Study

Shaji¹,

Devi²,

James³

et al. 2019

jebmh

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BACKGROUNDSepsis is responsible for 30-50% of the total neonatal deaths in developing countries and is considered the commonest cause of neonatal mortality. Neonatal sepsis has wide range of presentations with number of predisposing factors. Our study aims at detecting the risk factors of neonatal sepsis and to describe the clinical features and laboratory profile of neonates started on intravenous antibiotics for neonatal sepsis.METHODS 120 neonates (60 cases and 60 controls) admitted in the department of child health were enrolled in the present case control study and all cases were subjected to diagnostic evaluation and data was collected using restructured case record forms which included perinatal history, signs and symptoms associated with sepsis and laboratory investigations. Institutional Ethics Committee approved the study and written informed consent was obtained from all consenting mothers. Parameters are expressed as mean (SD) and as proportions. RESULTS52.5% neonates and 55% cases were males. 25% of cases were preterm deliveries and 21.7% cases were small for gestational age. Premature rupture of membranes (PROM), maternal urinary tract infections (UTI), and gestational diabetes mellitus (GDM) were seen in 16.7%, 10% and 28.3% cases. Hypothermia was a symptom of sepsis in 28.3% while fever was a symptom in 21.7% cases. CRP elevation and toxic granulations were seen in 75% and 33.3% cases. 6.7% cases had a positive blood culture. CONCLUSIONSManifestations of neonatal sepsis are non-specific. A high index of suspicion with or without laboratory evidences of sepsis is the key for early diagnosis. Prompt institution of antibiotic therapy and supportive care will save most of the cases of neonatal sepsis. HOW TO CITE THIS ARTICLE:Shaji SM, Devi S, Jemila J, et al. Role of maternal risk factors and neonatal clinical features in diagnosis of neonatal sepsis: a case control study.

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“…Severe thrombocytopeniaplatelet count less than 50 x10 3 / µ L(2, 3). Prolonged rupture of membrane-Rupture of membrane more than 18 hours (15).…”

Section: Operational De Nitionsmentioning

confidence: 99%

Prevalence of Thrombocytopenia and Its Associated Factors Among Neonates Admitted in Neonatal Intensive Care Unit of Addis Ababa Public Hospitals, Ethiopia 2020/21(Cross Sectional Study)

Wodaje¹,

Tadele

Lijaemiro

et al. 2022

Preprint

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Background: Thrombocytopenia is one of the most frequent hematologic disorders encountered in the sick neonate. This is evidenced by a fairly high prevalence among neonates admitted to the neonatal intensive care unit 22%-35%, especially in very-low-birth-weight and preterm neonates its prevalence is up to 70%-80%. In Africa, the prevalence of neonatal thrombocytopenia in Nigeria is 53%, 12.4% in Tunisia, and 16.2% in Libya. However, in Ethiopia, there is limited study assessed both its prevalence and associated factors. Objective: to assess the prevalence of thrombocytopenia and its associated factors among neonates admitted to neonatal intensive care unit at public hospitals in Addis Ababa in 2020/21.Method: Institution based cross sectional study was conducted at NICU of selected Addis Ababa public hospitals from February 15thto March 15th, 2021. Single population proportion formula was used to determine sample size. The final sample size was 423. The collected data entered using Epi data and exported to SPSS version 25 for analysis. Variables that have P-value<0.05in bivariable entered in to multivariable logistic regression model to control for confounder. Statistical significance declared at p-value <0.05.Results: The prevalence of neonatal thrombocytopenia in the study area is 66%.In this study variables such as eclampsia(AOR=4.8, 95%CI: 2.66-13.94), Prolonged rupture of membrane(AOR=0.26, 95%CI:0.101-0.669), Intra uterine growth retardation(AOR=0.26, 95%CI: 0.1-0.68), neonatal sepsis (AOR=11.98, 95%CI: 4.023-25.7), Perinatal asphyxia(AOR=6.68, 95%CI: 2.616-17.6), Necrotizing enterocolitis (AOR=14.6, 95%CI: 2.84-35.61) and prolonged nothing per mouth(AOR=0.243,95%CI: 0.084-0.705) were factors associated with neonatal thrombocytopenia.Conclusion and recommendation: Prevalence of neonatal thrombocytopenia in Addis Ababa public hospitals neonatal intensive care unit is high. Therefore, identifying factors associated with it used as an input in reducing the problem.

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Prolonged Rupture of Membranes, Neonatal Outcomes and Management Guidelines

Cited by 29 publications

References 23 publications

Risk factors associated with neonatal infectious and respiratory morbidity following preterm premature rupture of membranes

Risk factors associated with neonatal infectious and respiratory morbidity following preterm premature rupture of membranes

Role of Maternal Risk Factors and Neonatal Clinical Features in Diagnosis of Neonatal Sepsis: A Case Control Study

Prevalence of Thrombocytopenia and Its Associated Factors Among Neonates Admitted in Neonatal Intensive Care Unit of Addis Ababa Public Hospitals, Ethiopia 2020/21(Cross Sectional Study)

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