Planetary exploration in the harsh Venus surface environment faces a myriad of technical challenges related to material survivability, durability, and overall reliable systems operation. An understanding of material reactions in Venus relevant atmospheric conditions is core to enabling future successful Venus science missions. This work investigated various candidate materials used in fabricating electronics, sensors, and packaging after exposure to simulated Venus surface atmosphere. The NASA Glenn Extreme Environments Rig is capable of reproducing Venusian temperature, pressure, and atmospheric composition of the Venus surface consisting mostly of CO 2 and N 2 as well as traces of SO 2 , H 2 O, CO, OCS, HCl, HF, and H 2 S. The exposed materials were characterized using Auger electron spectroscopy, X-ray photoelectron spectroscopy, energy dispersive spectroscopy, field emission-scanning electron microscopy, X-ray diffraction, and optical imaging. The reactivity of the sulfur gas constituents with several of the exposed materials were found to have adverse effects on the materials, particularly those composed of transition metals. Alloys, brazes, and cladded materials all exhibited extensive reactions. In contrast, compounds of SiC, SiO 2 , Al 2 O 3 , and elemental Au and Ir were found to be chemically inert. The fundamental experimental understanding of material interactions with the simulated Venusian environment gained in this study enables improved selection of materials and hardware designs that would increase the success margin of future long duration science mission on Venus.Plain Language Summary Exploration of our sister planet Venus has been severely impeded to date due to its high temperature (467°C), high pressure (90× that of Earth), and hostile surface environment. The atmosphere not only is mostly carbon dioxide and nitrogen but also contains trace amounts of highly reactive compounds of sulfur, chlorine, and fluorine. Previous space probes to the planet lasted at most a couple of hours before the surface environment caused them to fail. A study was done in which various materials used to build spacecraft were put in a chamber specifically designed to simulate the Venus environment, complete with the trace amounts of the corrosive gases. This paper details what happened to the materials that were exposed and explores which ones reacted catastrophically and which ones remained intact and are therefore viable candidates for Venus surface mission use. Based on our findings, we strongly recommend that all future missions test their components in a similar full Venus environment.