Promethazine and pethidine in anaesthesia

Enantioselective Molecular Recognition of Chiral Organic Ammonium Ions and Amino Acids Using Cavitand–Salen‐Based Receptors

“…Many natural processes such as immunological responses,1a the mechanism of drug action,1b and the storage and retrieval of genetic information1c are regulated by enantiomeric discrimination processes. The development of chiral artificial receptors possessing chiral recognition properties has attracted increasing attention because of their high sensitivity and potential applications in pharmaceuticals,2,3 analysis,4,5 biology,6 catalysis,7–9 and sensing 10.…”

Clinical Significance of the Effects of Thiopentone and Adjuvant Drugs on Blood Sugar and Glucose Tolerance

“…The importance of these latter two factors in causing hyperglycaemia is shown when the effects of morphia and promethazine are compared (table I) as premedicant drugs. Although it has never been proven conclusively, many authors refer to the fact that promethazine is much less potent a respiratory depressant than the opiates (Hopkin et al, 1957). Mclntyre (1947) listed sixteen references to the hyperglycaemic action of curare.…”

The Effects of Premedication With Phenothiazine Derivatives on the Course of Methohexitone Anaesthesia

“…In a recently published textbook, Foster (1959) claims that the use of promethazine prevents such disturbances as bucking, coughing and spasm during anaesthesia. Previous writers have noted that this drug makes laryngeal reflexes less active (Dinnick, 1954;Hopkin, Hunter and Jones, 1957); enables endotracheal tubes to be better tolerated (Harrison, 1955); and relieves bronchospasm (Loyn, 1956;Watkinson, 1960). Hunter (1958) has made similar claims for the action of pecazine.…”