Promigratory and proangiogenic effects of AdipoRon on bone marrow-derived mesenchymal stem cells: an in vitro study

Abstract

Preconditioning of MSCs with AdipoRon prior to transplantation could enhance cell survival, angiogenesis and migration via activating the COX-2/PGE2/HIF-1 pathway and other contributing factors.

An adiponectin receptor agonist promote osteogenesis via regulating bone‐fat balance

“…In addition, APR showed no effect on the proliferation or cell cycle distribution of rat bone marrow mesenchymal cells and adipocyte‐derived mesenchymal cells, but APR significantly promoted cell migration of them. The results were consistent with previous study that the migration ability of mesenchymal cells (MSCs) could be enhanced by APR potentially via activating COX‐2/PGE2/HIF‐1 pathway 17 . Moreover, we further investigated the effect of APR on bone‐fat cross‐talk including osteogenesis‐osteoclastogenesis balance and osteogenesis‐adipogenesis balance.…”

“…The results were consistent with previous study that the migration ability of mesenchymal cells (MSCs) could be enhanced by APR potentially via activating COX-2/PGE2/HIF-1 pathway. 17 Moreover, we further investigated the effect of APR on bone-fat cross-talk including osteogenesis-osteoclastogenesis balance and osteogenesis-adipogenesis balance. Our results suggested that APR could promote osteogenic differentiation of both osteoblastprecursor cells and MSCs, inhibit osteoclast differentiation from osteoclast-precursor cells and decrease adipogenesis of MSCs.…”

“…16 APR was found to improve glucose intolerance as well as insulin resistance in high-fat diet mice model. 16 Few studies also suggested that APR could increase the survival, migration of bone marrow mesenchymal stem cells (BMSCs), 17 promote diabetic fracture repair and alveolar bone regeneration. 18,19 However, it is still lacking sufficient investigations regarding the effect of APR on the regulation of bone-fat balance.…”

Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

“…AdipoRON effectively improved insulin sensitivity and restored glucose homeostasis via the activation of AdipoR1-AMPK-PGC1α and AdipoR2-PPARα signaling pathways (162). AdipoRON treatment also mimicked adiponectin's established anti-diabetic effects (163) and ability to enhance cellular capacity for mitigating oxidative-stress (162,164), enhancing lipid/glucose oxidation in mitochondria (162,164), anti-inflammatory responses (162,(164)(165)(166)(167), lifeprolonging effect (162,163), anti-cancer effects (168,169), procell survival and anti-apoptotic effect (170,171), neuronal- (172,173), reno- (174,175), and cardio-/vascular-protective effects (165,(176)(177)(178)(179). However, exciting AdipoRON research in animal models has not been translated to establishment of a drug for human use and the search continues for additional small molecule AdipoR agonists which have little or no toxicity.…”