2007
DOI: 10.1158/1078-0432.ccr-07-0237
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Prominent Microvascular Proliferation in Clinically Aggressive Neuroblastoma

Abstract: Purpose: Tumor vasculature is disorganized and glomeruloid microvascular proliferation (MVP) has been identified as a poor prognosticator in some adult cancers. To determine the clinical significance of MVP, including glomeruloid MVP in neuroblastoma, we initially examined vessel architecture in tumor sections from 51 children diagnosed at Children's Memorial Hospital (CMH) and subsequently evaluated 154 neuroblastoma tumors on a tissue microarray constructed at Children's Hospital of Philadelphia (CHOP). E… Show more

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Cited by 37 publications
(36 citation statements)
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“…reports is far from clear (14)(15)(16)(17)(18)(19). Interestingly, analysis of our VEGF data revealed no correlation between fraction or staining intensity of VEGF-positive cells and clinical stage (fraction: ρ = -0.001; intensity: ρ = 0.05; Fig.…”
Section: Resultsmentioning
confidence: 77%
“…reports is far from clear (14)(15)(16)(17)(18)(19). Interestingly, analysis of our VEGF data revealed no correlation between fraction or staining intensity of VEGF-positive cells and clinical stage (fraction: ρ = -0.001; intensity: ρ = 0.05; Fig.…”
Section: Resultsmentioning
confidence: 77%
“…High levels of angiogenesis or proangiogenic regulators have been associated with a poor clinical outcome in neuroblastoma (Meitar et al, 1996;Eggert et al, 2000;Komuro et al, 2001;Peddinti et al, 2007). However, this is controversial, and conflicting findings have been reported (Canete et al, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, in addition to a more differentiated phenotype, Schwannian stroma rich tumours also display low vascularity (Meitar et al, 1996). A correlation between low vascular density and absence of microvascular proliferation in Schwannian stroma-rich tumours have been demonstrated (Peddinti et al, 2007). On the contrary, high vascular index and abnormal blood vessels have been associated to clinical aggressiveness in Schwannian stroma-poor neuroblastoma tumours (Meitar et al, 1996;Peddinti et al, 2007).…”
Section: Role Of Schwann Cells In Angiogenesismentioning
confidence: 99%
“…A correlation between low vascular density and absence of microvascular proliferation in Schwannian stroma-rich tumours have been demonstrated (Peddinti et al, 2007). On the contrary, high vascular index and abnormal blood vessels have been associated to clinical aggressiveness in Schwannian stroma-poor neuroblastoma tumours (Meitar et al, 1996;Peddinti et al, 2007). This association between abundant Schwannian stroma, neuronal differentiation and decrease vascularity had led to the hypothesis that Schwann cells may secrete soluble factors capable of inducing neuroblast differentiation and inhibit angiogenesis (Huang et al, 2000).…”
Section: Role Of Schwann Cells In Angiogenesismentioning
confidence: 99%