Promising prognostic markers of Preeclampsia: New avenues in waiting

Jadli, Anshul; Sharma, Nitika; Damania, Kaizad; Satoskar, Purnima; Bansal, Vandana; Ghosh, Kanjaksha; Shetty, Shrimati

doi:10.1016/j.thromres.2015.05.011

Cited by 31 publications

(14 citation statements)

References 77 publications

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“…Women with multiple gestations, hypertension, a history of PE, gestational diabetes mellitus, vascular disease, systemic diseases, proteinuria, urinary tract infection during early pregnancy, previous bad obstetric history, obstetric complications of the current pregnancy or fetal anomaly were excluded. Under the inclusion and exclusion criteria, 100 first time pregnant women between 17 and 44 years of age who had completed 20 weeks of gestation were randomly selected and divided into two groups according to previous studies …”

Section: Methodsmentioning

confidence: 99%

“…Under the inclusion and exclusion criteria, 100 first time pregnant women between 17 and 44 years of age who had completed 20 weeks of gestation were randomly selected and divided into two groups according to previous studies. 17,18 Group 1 included normotensive non-smoking women (n = 40) with no medical record of disease and was the control group. Group 2 consisted of PE women (n = 60).…”

Section: Methodsmentioning

confidence: 99%

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Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones

Al-Kaabi

Hamdan

Al-Matubsi

2020

J of Obstet and Gynaecol

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Aims To evaluate plasma kisspeptin‐10 (KP‐10) as a marker for preeclampsia and assess its relation to altered reproductive hormones in preeclamptic pregnant women. Methods First time pregnant women (n = 100) at 20 weeks of gestation participated in this study and divided into preeclamptics (n = 60) and normotensives (n = 40). KP‐10, luteinizing hormone (LH), follicle stimulating hormone (FSH), beta‐human chorionic gonadotropin (β‐hCG), estradiol (E2) and progesterone were evaluated during 2nd and 3rd trimesters of pregnancy for all women. Results Kisspeptin‐10 levels were reduced in preeclampsia (PE) women compared with normotensive pregnancies. In the 2nd trimester, area under receiver–operator characteristic (ROC) curve was 0.662, positive and negative predictive values were 32.8 and 94.6, and test sensitivity and specificity were 55% and 87.5%, respectively. In the 3rd trimester, area under ROC curve was 0.747 positive and negative predictive values were 22.2 and 97.3, and test sensitivity and specificity were 83.3% and 67.5%, respectively. In PE patients, plasma KP‐10 demonstrated an inverse correlation with E2 (during the 2nd trimester), LH and FSH (during the 3rd trimester), and positively correlated with β‐hCG (during the 3rd trimester). Conclusion This study showed significantly reduced plasma KP‐10 levels in PE women. This suggests that KP‐10 may play an important role in the pathophysiology of PE. Therefore, combined with previous studies, to diagnose the PE, testing for maternal KP‐10 plasma levels may be useful as an effective screening, but because of low positive predictive value and inadequate test sensitivity, screening cannot be recommended. Furthermore, KP‐10 in PE patients demonstrated significant positive correlation with β‐hCG.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones

Al-Kaabi

Hamdan

Al-Matubsi

2020

J of Obstet and Gynaecol

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“…MPs as derivate of cellular membrane are discussed powerful paracrine regulators of target cell functions [30][31][32]. Indeed, MPs possess a wide spectrum of biological effects on intercellular communication by transferring different molecules (autoantigens, cytokines, mRNA, iRNA, hormones, tissue coagulation factors, and surface receptors) able to modulate other cells affected growth of tissue, reparation, vasculogenesis, inflammation, apoptosis, infection, The number of red blood cell-derived microparticles in predicting periprocedural adverse effects in acute ST-segment elevation myocardial infarction patients Copyright: © 2017 Berezin and malignancy [33][34][35][36][37][38][39]. Moreover, RBC-MPs act as NO promoter exerted an erythrocrine function by synthesizing, transporting and releasing NO metabolic products contributing in regulation of vascular tone.…”

Section: Biological Role and Function Of Mpsmentioning

confidence: 99%

The number of red blood cell-derived microparticles in predicting periprocedural adverse effects in acute STsegment elevation myocardial infarction patients

Berezin¹

2017

JCTCD

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“…Growing evidence supports the idea that regarding association between immune pattern of MPs originated from different cells (endothelial cells, mononuclears, dendritic cells, platelets) and nature evolution of various diseases including CV diseases, cancer, sepsis, eclampsia, autoimmune and metabolic states, etc. [30][31][32][33].…”

Section: Biological Role and Function Of Mpsmentioning

confidence: 99%

The Clinical Utility of Circulating Microparticles’ Measurement in Heart Failure Patients

Berezin¹

2016

Vasc Med Surg

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Heart failure (HF) continues to have a sufficient impact on morbidity, mortality and disability in developed countries. Growing evidence supports the hypothesis that microparticles (MPs) might contribute to the pathogenesis of the HF development paling a pivotal role in the regulation of the endogenous repair system, thrombosis, coagulation, inflammation, immunity and metabolic memory phenomenon. Therefore, there is a large body of data clarifying the predictive value of MP numerous in circulation among subjects with HF. Although determination of MP signature is better than measurement of single MP circulating level, there is not yet closely confirmation that immune phenotype of cells produced MPs are important for HF prediction and development. The aim of the review: to summarize knowledge regarding the measurement of number of various MPs subsets in HF patients.

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Promising prognostic markers of Preeclampsia: New avenues in waiting

Cited by 31 publications

References 77 publications

Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones

Maternal plasma kisspeptin‐10 level in preeclamptic pregnant women and its relation in changing their reproductive hormones

The number of red blood cell-derived microparticles in predicting periprocedural adverse effects in acute STsegment elevation myocardial infarction patients

The Clinical Utility of Circulating Microparticles’ Measurement in Heart Failure Patients

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