Promising reagents for difluoroalkylation

Abstract

<p>This review described recent advances in difluoroalkylation reaction using different substrates. Generally speaking, RCF2 radical was generally proposed in the mechanism of these reactions. At present, the most used difluoroalkylation...</p>

Direct benzylic C–H difluoroalkylation with difluoroenoxysilanes by transition metal-free photoredox catalysis

“…4 However, compared with the well-developed fluorination and perfluoroalkylation, difluoroalkylation still suffers from some challenges, such as limited difluoroalkylating reagents and the lack of general and efficient strategies. 2 a ,5 Hence, the development of diversity-oriented methods for difluoroalkylation will be highly demanding.…”

Difluoromethylation of heterocyclesviaa radical process

“…[10][11][12] However, these difluoromethyl sources are volatile, unstable, and hazardous, and the related platforms suffer from poor compatibility of functional groups and require harsh reaction conditions. 13 In this context, difluoromethylation via a free radical process has emerged as an alternative in terms of its unique reaction efficiency and selectivity. In 1994, Chen and coworkers reported the pioneering work of constructing a CF 2 H unit from HCF 2 I via a plausible radical process.…”

Palladium-Catalyzed Cascade Difluoroalkylation and Phosphinoylation of 2-Vinyloxy Arylalkynes: Selective Synthesis of Difluoroalkyl-Containing Tetrasubstituted Alkenylphosphine Oxides

“…However, owing to the special physicochemical properties of difluoromethylene group (CF 2 ), numerous elegant protocols have been developed to incorporate a difluoroalkyl group into organic molecular skeletons . Among them, CF 2 -radical-triggered 1,2-difunctionalization such as difluoroalkylation-arylation, -carbonylation, -cyanation, -trifluoromethylthiolation, -borylation, and -phosphinoylation of alkynes toward the synthesis of valuable difluoroalkylated alkenes has shown significant progress.…”