Promising strategies employing nucleic acids as antimicrobial drugs

Moreira, Luís; Guimarães, Nuno M.; Santos, Rita S.; Loureiro, Joana A.; Pereira, Maria C.; Azevedo, Nuno F.

doi:10.1016/j.omtn.2024.102122

Cited by 5 publications

(3 citation statements)

References 161 publications

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“…118,119 These nucleotides are antisense oligonucleotides and oligomers, DNAzymes, and transcription factor decoys comprising nucleic acid analogues that protect them against endonucleases. 118 Antisense 9-mer peptide nucleic acid (PNA), a nucleotide− peptide conjugate, demonstrated efficient clearance of uropathogenic Escherichia coli (UPEC) by targeting essential genes of this pathogen. 119 Hence, further understanding of different classes of sRNAs and global regulatory proteins and their role in persistence will open up new avenues for the modified nucleotide-based eradication of bacterial persisters.…”

Section: ■ Riboregulation Of Persistence Phenotypementioning

confidence: 99%

“…However, as antibiotic persistence results from an overlap of the aforementioned pathways, targeting global regulatory units may prove to be an excellent antipersister strategy. Recently, there has been a growing interest in the field of unconventional nucleic acid conjugates to combat AMR. , These nucleotides are antisense oligonucleotides and oligomers, DNAzymes, and transcription factor decoys comprising nucleic acid analogues that protect them against endonucleases . Antisense 9-mer peptide nucleic acid (PNA), a nucleotide–peptide conjugate, demonstrated efficient clearance of uropathogenic Escherichia coli (UPEC) by targeting essential genes of this pathogen .…”

Section: Riboregulation Of Persistence Phenotypementioning

confidence: 99%

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Decoding Bacterial Persistence: Mechanisms and Strategies for Effective Eradication

Sett,

Dubey,

Bhowmik

et al. 2024

ACS Infect. Dis.

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The ability of pathogenic bacteria to evade antibiotic treatment is an intricate and multifaceted phenomenon. Over the years, treatment failure among patients due to determinants of antimicrobial resistance (AMR) has been the focal point for the research and development of new therapeutic agents. However, the survival of bacteria by persisting under antibiotic stress has largely been overlooked. Bacterial persisters are a subpopulation of sensitive bacterial cells exhibiting a noninheritable drug-tolerant phenotype. They are linked to the recalcitrance of infections in healthcare settings, in turn giving rise to AMR variants. The importance of bacterial persistence in recurring infections has been firmly recognized. Fundamental work over the past decade has highlighted numerous unique tolerance factors contributing to the persister phenotype in many clinically relevant pathogens. This review summarizes contributing factors that could aid in developing new strategies against bacterial antibiotic persisters.

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Section: ■ Riboregulation Of Persistence Phenotypementioning

confidence: 99%

Section: Riboregulation Of Persistence Phenotypementioning

confidence: 99%

Decoding Bacterial Persistence: Mechanisms and Strategies for Effective Eradication

Sett,

Dubey,

Bhowmik

et al. 2024

ACS Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…Antimicrobial resistance (AMR), especially infections caused by carbapenem resistant enterobacteriaceae (CRE), is the most serious situation, which has posed a serious threat to global public health. 1–3 Colistin has become the ‘last resort’ antibiotic for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, with the reuse of colistin, colistin resistance has also increased.…”

Section: Introductionmentioning

confidence: 99%