Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9

Salama, Abeer; Allam, Rasha M.

doi:10.1016/j.ejphar.2020.173763

Cited by 48 publications

(27 citation statements)

References 57 publications

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“…In addition, prunetin demonstrated signi cant anti-proliferative effects on MCF-7, Caco-2 and A-549 cells, reducing their viability. These ndings are in agreement with the in vitro results of this study, which demonstrated that high concentration of prunetin caused cytotoxicity similar to those caused by other iso avones [30,31,32]. Our results have shown that prunetin's anti-tumorigenic effects are mediated by inhibiting cellular growth of the target cell line RT-4 for further studies.…”

Section: Discussionsupporting

confidence: 92%

Prunetin Inhibits Nitric Oxide Activity, Proliferation and Induces Apoptosis in Urinary Bladder Cancer Cells (RT-4) Through the Enhancement of Apoptotic Pathway via CASP3 and TNF-α Genes That Are Involved

Karayıldırım

Nalbantsoy

Yavaşoğlu

2021

Preprint

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Urinary bladder cancer is considered one of the most prevalent malignant tumors worldwide. Complementary and integrative approaches for the treatment of bladder cancer, such as the intake of isoflavonoid phytoestrogens, are increasingly explored due to the risk of mortality and long-term morbidity associated with surgical procedures. The biological effects of prunetin, one of the less-studied phytoestrogens, have not yet been examined in this respect. Therefore, this study aimed to explore the efficacy of prunetin on urinary bladder cancer cells (RT-4). Cytotoxicity, nitric oxide synthase activity, apoptotic gene expression and cell cycle assays were performed to determine the biological effect of prunetin exposure on cellular toxicity, cell cycle progression and the expresions of selected apoptosis-related genes. The results suggested that prunetin has cytotoxic effects on RT-4 cells at 21.11 µg/mL. Flow cytometry analysis showed that prunetin induced apoptosis and cell cycle arrested in G0/G1 phase. Prunetin exposure was associated with increases in CASP3 and TNF-α gene expression in RT-4 cells at doses of 21.11 µg/mL and 42.22 µg/mL. Strong nitric oxide inhibition was determined with IC50 of 5.18 µg/mL under macrophage mediated inflammatory circumstances. Based on the experimental data, it is reasonable to conclude that prunetin possesses anti-cancer properties and may be a candidate compound for the prevention of urinary bladder cancer. This is the first study that evaluated prunetin for its in vitro antitumor activities, clarified its possible apoptotic molecular mechanism and provided novel insights into its anti-inflammatory nature and effects on the expression of related key genes.

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Section: Discussionsupporting

confidence: 92%

Prunetin Inhibits Nitric Oxide Activity, Proliferation and Induces Apoptosis in Urinary Bladder Cancer Cells (RT-4) Through the Enhancement of Apoptotic Pathway via CASP3 and TNF-α Genes That Are Involved

Karayıldırım

Nalbantsoy

Yavaşoğlu

2021

Preprint

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“…This may be related to the antitumour effect of DAI itself. DAI can inhibit the growth of ovarian cancer, breast cancer, colorectal cancer and other tumour cells (He et al, 2016; Hua, Li, Chen, & Liu, 2018; Salama & Allam, 2020; Wang et al, 2020). This characteristic of DAI is very important for its transformation into a drug against DDP‐induced skeletal muscle atrophy and cachexia.…”

Section: Discussionmentioning

confidence: 99%

Daidzein alleviates cisplatin‐induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway

Zhang

Chi

Chen

et al. 2021

Phytotherapy Research

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Cisplatin (DDP) is widely used in cancer treatment, but DDP can cause skeletal muscle atrophy and cachexia. This study explored the effect and mechanism of daidzein (DAI) in reducing DDP‐induced skeletal muscle atrophy and cachexia in vivo and in vitro. DAI alleviated the weight, food intake, muscle, adipose tissue, kidney weight and forelimb grip of LLC tumour‐bearing mice after DDP treatment, and did not affect the antitumour effect of DDP. DAI can reduce the decrease of the cross‐sectional area of skeletal muscle fibre‐induced by DDP and prevent the change of fibre type proportion. In skeletal muscle, it can inhibit Glut4/AMPK/FoxO pathway, down‐regulate the expression of atrogin1 and MuRF1, and inhibit skeletal muscle protein degradation. In DDP treated C2C12 myotubes, DAI could inhibit Glut4/AMPK/FoxO pathway to reduce myotubes atrophy, while AMPK agonist MK‐3903 could reverse the protective effect of DAI. These results suggest that DAI can alleviate DDP‐induced skeletal muscle atrophy by downregulating the expression of Atrogin1 and MuRF1 through the regulation of Glut4/AMPK/FoxO pathway.

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“…Eight of them (daidzein, genistein, glycitein, daidzin, genistin, glycitin, malonyldaidzin, and malonylgenistin) were reported in all soy organs. Recent works showed promising biological activities of daidzein against colon cancer and hepatitis C virus [111,112]. Daidzin, which is a glyco-conjugate form of daidzein, presented therapeutic properties against multiple myeloma and epilepsy [113,114].…”

Section: Bioactive Compounds In Underused Soy Partsmentioning

confidence: 99%

Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

Bragagnolo

Funari

Ibáñez

2021

Foods

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The valorization of agri-food by-products is essential from both economic and sustainability perspectives. The large quantity of such materials causes problems for the environment; however, they can also generate new valuable ingredients and products which promote beneficial effects on human health. It is estimated that soybean production, the major oilseed crop worldwide, will leave about 597 million metric tons of branches, leaves, pods, and roots on the ground post-harvesting in 2020/21. An alternative for the use of soy-related by-products arises from the several bioactive compounds found in this plant. Metabolomics studies have already identified isoflavonoids, saponins, and organic and fatty acids, among other metabolites, in all soy organs. The present review aims to show the application of metabolomics for identifying high-added-value compounds in underused parts of the soy plant, listing the main bioactive metabolites identified up to now, as well as the factors affecting their production.

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Promising targets of chrysin and daidzein in colorectal cancer: Amphiregulin, CXCL1, and MMP-9

Cited by 48 publications

References 57 publications

Prunetin Inhibits Nitric Oxide Activity, Proliferation and Induces Apoptosis in Urinary Bladder Cancer Cells (RT-4) Through the Enhancement of Apoptotic Pathway via CASP3 and TNF-α Genes That Are Involved

Prunetin Inhibits Nitric Oxide Activity, Proliferation and Induces Apoptosis in Urinary Bladder Cancer Cells (RT-4) Through the Enhancement of Apoptotic Pathway via CASP3 and TNF-α Genes That Are Involved

Daidzein alleviates cisplatin‐induced muscle atrophy by regulating Glut4/AMPK/FoxO pathway

Metabolomics as a Tool to Study Underused Soy Parts: In Search of Bioactive Compounds

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