Promoter methylation and loss of p16^INK4a gene expression in head and neck cancer

Abstract

Our data indicate that methylation of the p16(INK4a) gene is a frequent event in primary head and neck cancer and that it plays a major role in the silencing of p16(INK4a) gene expression during tumor development.

Validation of methylation markers for diagnosis of oral cavity cancer

“…In HNSCC, aberrant promoter methylation of CpG islands may affect genes involved in DNA repair [22,[28][29][30][31][32], cell-cycle control [22,[28][29][30][31]33,34], apoptosis [15,22,23,28,30,34,35], cell differentiation [23], cell proliferation [23] and cell adhesion [22,29,36,37].…”

Recent Progress in Triple Negative Breast Cancer Research

“…p16 is a well-documented tumor suppressor gene in many cancers, notably melanoma, oropharyngeal squamous cell carcinoma, cervical cancer and esophageal cancer. In these tumours, the functions of p16 may be lost due to mutations or suppression of its transcription by promoter methylation (Demokan et al, 2012;Jha et al, 2012;Peurala et al, 2013;Khor et al, 2013;Wani et al, 2013).…”

Expression profiles of selected genes in tumors and matched surgical margins in oral cavity cancer: Do we have to pay attention to the molecular analysis of the surgical margins?

“…It is associated with abnormalities in proliferation, apoptosis, differentiation, cell cycle regulation, DNA repair, signal transduction, and angiogenesis. 2 The instability of the genome, chromosomal rearrangement and loss of DNA fragments are associated with carcinogenesis of HNSCC. 3 Califano et al proposed a model for the dynamics of chromosomal damage in the course of cancers of the head and neck.…”