Promoter methylation status of RORC, IL17A, and TNFA in peripheral blood leukocytes in adolescents with obesity-related asthma

Leija-Martínez, José J.; Giacoman-Martínez, Abraham; Del-Río-Navarro, Blanca E.; Sánchez‐Muñoz, Fausto; Hernández-Díazcouder, Adrián; Muñoz‐Hernández, Onofre; Romero‐Nava, Rodrigo; Villafaña, Santiago; Marchat, Laurence A.; Hong, Enrique; Huang, Fengyang

doi:10.1016/j.heliyon.2022.e12316

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…Numerous genetic variations linked to obesity-related asthma have been pinpointed in research studies, encompassing ADIPOQ [97,98], retinoid-related orphan receptor C (RORC), IL17A [99], TNF-α [100-102], beta-2 adrenergic receptor (ADRB2) [103], and IL-6 [104]. This form of asthma, associated with obesity, is influenced by gender and is more prevalent among females.…”

Section: Obesity-related Asthmamentioning

confidence: 99%

Asthma Phenotypes in the Era of Personalized Medicine

Gonzalez-Uribe,

Romero-Tapia,

Castro-Rodriguez

2023

JCM

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Asthma is a widespread disease affecting approximately 300-million people globally. This condition leads to significant morbidity, mortality, and economic strain worldwide. Recent clinical and laboratory research advancements have illuminated the immunological factors contributing to asthma. As of now, asthma is understood to be a heterogeneous disease. Personalized medicine involves categorizing asthma by its endotypes, linking observable characteristics to specific immunological mechanisms. Identifying these endotypic mechanisms is paramount in accurately profiling patients and tailoring therapeutic approaches using innovative biological agents targeting distinct immune pathways. This article presents a synopsis of the key immunological mechanisms implicated in the pathogenesis and manifestation of the disease’s phenotypic traits and individualized treatments for severe asthma subtypes.

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Section: Obesity-related Asthmamentioning

confidence: 99%

Asthma Phenotypes in the Era of Personalized Medicine

Gonzalez-Uribe,

Romero-Tapia,

Castro-Rodriguez

2023

JCM

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“…Several variations in genes associated with obesity-related asthma have been identified in research studies (ADIPOQ [97,98], retinoid-related orphan receptor C, IL17A [99], TNF-α [100-102], beta-2 adrenergic receptor [103], IL-6 [104]). Obesity-related asthma is a gender-determined phenotype that is more prevalent in females.…”

Section: Obesity Related Asthmamentioning

confidence: 99%

Asthma Phenotypes in the Era of Personalized Medicine

González-Uribe¹,

Romero-Tapia²,

Castro-Rodriguez³

2023

Preprint

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Asthma is a prevalent disease that around 300 million worldwide, resulting in substantial morbidity, mortality, and economic burden on a global scale. New clinical and laboratory research has shed light on the immunology causing asthma. Asthma is now recognized as a heterogeneous disease. A personalized medicine is based on the classification of asthma by endotype by linking observable characteristics to immunological mechanisms. Identifying endotype mechanisms is essential for better characterizing patients and personalizing therapeutic approaches with novel biological agents that target specific immune pathways. This article provides a summary of the major immunological mechanisms involved in the pathogenesis and emergence of the disease's phenotypic features, as well as the individualized treatment for severe asthma subtypes

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“…Obesity complicates asthma phenotypes, and previous research highlighted its possibility associated with obesity-induced lipid status disturbances and chronic systemic inflammation (Miethe et al, 2020). In addition to classical atopic asthma, children with obesity-related asthma exhibit CD4 + T cells polarizing toward Th1 and Th17 profiles (Nyambuya et al, 2020;Leija-Martínez et al, 2022). With technological advancements in the microbiome field, increasing evidence has linked obesity, asthma, and dysbiosis of the gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Complex interplay of gut microbiota between obesity and asthma in children

Hu,

Zhao,

Liu

et al. 2023

Front. Microbiol.

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Obesity is an important risk factor and common comorbidity of childhood asthma. Simultaneously, obesity-related asthma, a distinct asthma phenotype, has attracted significant attention owing to its association with more severe clinical manifestations, poorer disease control, and reduced quality of life. The establishment of the gut microbiota during early life is essential for maintaining metabolic balance and fostering the development of the immune system in children. Microbial dysbiosis influences host lipid metabolism, triggers chronic low-grade inflammation, and affects immune responses. It is intimately linked to the susceptibility to childhood obesity and asthma and plays a potentially crucial transitional role in the progression of obesity-related asthma. This review article summarizes the latest research on the interplay between asthma and obesity, with a particular focus on the mediating role of gut microbiota in the pathogenesis of obesity-related asthma. This study aims to provide valuable insight to enhance our understanding of this condition and offer preliminary evidence to support the development of therapeutic interventions.

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Promoter methylation status of RORC, IL17A, and TNFA in peripheral blood leukocytes in adolescents with obesity-related asthma

Cited by 3 publications

References 41 publications

Asthma Phenotypes in the Era of Personalized Medicine

Asthma Phenotypes in the Era of Personalized Medicine

Asthma Phenotypes in the Era of Personalized Medicine

Complex interplay of gut microbiota between obesity and asthma in children

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