Promoter polymorphism of MRP1 associated with reduced survival in hepatocellular carcinoma

Abstract

the MRP1 -1666GG genotype predicted a worse outcome and was an independent predictor of poor survival in patients with HCC from Southeast China.

Association of Two Polymorphic Codons in P53 and ABCC1 Promoter with Prostate Cancer

“…Previous reports suggested that a functional polymorphism in codon 72 of p53 gene, which encodes polyproline domain with a vital role in apoptosis induction, is in relation to the most cancers (18)(19)(20)(21)(22)(23) and prevalence of exon 5-8 mutations, which encodes the DNA binding domain of the TP53 molecule are found in many of human cancers (5,26). On the other hand, a report by Zhao et al, indicated that promoter polymorphism of ABCC1 gene too, is associated with cancer development (10). Here, polymorphisms of 72 and 282 codons of p53 gene and promoter of ABCC1 were investigated.…”

“…Evidences indicated that SNPs within the ABCC1 (MRP1) are important in predicting the response to chemotherapy in different cancers. This gene can induce a characteristic mutation in p53 (10,30). Previous studies have shown that p53 mutations are significantly associated with a poor prognosis for patients with cancer (32).…”

“…SNPs in the coding region of ABCC1 gene have been shown to affect its function (9,10). Recent studies have revealed that G-1666A polymorphism on promoter region of ABCC1 is a risk factor for cancer.…”

“…Recent studies have revealed that G-1666A polymorphism on promoter region of ABCC1 is a risk factor for cancer. It has been nearly 15years since the initial experiments of Chin et al demonstrated transcriptional dependence of the MDR1 gene promoter by p53 (8,(10)(11). To clarify the association of codon 72 and 282 polymorphisms of p53 gene and G-1666A promoter polymorphism of ABCC1 gene with the risk of prostate cancer, a case-control study of 45 controls and 45 paraffin embedded samples of patients with confirmed prostate cancer was performed.…”

MRP1 G1666A gen polimorfizmi ile idrar arsenik düzeyleri arasındaki ilişki

“…Literatürde, bu proteini kodlayan gendeki polimorfizmlerin, protein ifadesini değiştirdiğini gösteren çalışmalar da bulunmaktadır (17). Bununla birlikte, mrP1'i kodlayan genlerdeki polimorfizmlerin idrar arsenik düzeylerine etkisini Türk populasyonunda araştıran bir çalışmaya literatür taramalarında rastlanmamıştır.…”