Promoter-region hypermethylation and expression downregulation of Yy1 (Yin yang 1) in preneoplastic liver lesions in a thioacetamide rat hepatocarcinogenesis model

Abe, Hajime; Ogawa, Takashi; Wang, Liyun; Kimura, Masayuki; Tanaka, Takeshi; Morita, Rimpei; Yoshida, Toshinori; Shibutani, Makoto

doi:10.1016/j.taap.2014.08.013

Cited by 7 publications

References 37 publications

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Bisphenol A exposure disrupts aspartate transport in HepG2 cells

Jiménez‐Torres¹,

Hernández‐Kelly²,

Najimi

et al. 2020

J Biochem & Molecular Tox

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The liver is the organ responsible for bisphenol A (BPA) metabolism, an environmental chemical agent. Exposure to this toxin is associated with liver abnormalities and dysfunction. An important role played by excitatory amino acid transporters (EAATs) of the slc1 gene family has been reported in liver injuries. To gain insight into a plausible effect of BPA exposure in the liver glutamate/aspartate transport, using the human hepatoblastoma cell line HepG2, we report a BPA‐dependent dynamic regulation of SLC1A3 and SLC1A2. Through the use of radioactive [3H]‐ d‐aspartate uptake experiments and immunochemical approaches, we characterized time and dose‐dependent regulation of the protein levels and function of these transporters after acute exposure to BPA. An increase in nuclear Yin Yang 1 was found. These results suggest an important involvement of the EAATs in liver physiology and its disruption after acute BPA exposure.

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Bisphenol A exposure disrupts aspartate transport in HepG2 cells

Jiménez‐Torres¹,

Hernández‐Kelly²,

Najimi

et al. 2020

J Biochem & Molecular Tox

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show abstract

Expression of YY1 in Differentiated Thyroid Cancer

et al. 2015

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The transcription factor Yin Yang 1 (YY1) has an important regulatory role in tumorigenesis, but its implication in thyroid cancer has not been yet investigated. In the present study, we have analyzed the expression of YY1 in differentiated thyroid cancer and assessed the association of YY1 expression with clinical features. Expression of YY1 was evaluated in human thyroid cancer cell lines, a series of matched normal/tumor thyroid tissues and in a thyroid cancer tissue microarray, using real-time PCR, Western blot, and/or immunohistochemistry. YY1 was overexpressed in thyroid cancer cells, at transcription and protein levels. A significant increase of YY1 mRNA was also observed in tumor thyroid tissues. Moreover, immunohistochemical analysis of the thyroid cancer tissue microarray revealed that both papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) present increased YY1 protein levels (48 and 19%, respectively). After stratification by the level of YY1 protein, positive YY1 expression identifies 88% of patients with PTC. The association of YY1 expression with clinicopathological features in PTC and FTC showed that YY1 expression was related with age at diagnosis. Our data indicates for the first time overexpression of YY1 in differentiated thyroid cancer, with YY1 being more frequently overexpressed in the PTC subtype.

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Models to Study Liver Regeneration

Pritchard

Apte

2015

Liver Regeneration

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Promoter-region hypermethylation and expression downregulation of Yy1 (Yin yang 1) in preneoplastic liver lesions in a thioacetamide rat hepatocarcinogenesis model

Cited by 7 publications

References 37 publications

Bisphenol A exposure disrupts aspartate transport in HepG2 cells

Bisphenol A exposure disrupts aspartate transport in HepG2 cells

Expression of YY1 in Differentiated Thyroid Cancer

Models to Study Liver Regeneration

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