Background: Active engagement across a range of methodological frameworks is one hallmark of thriving scholarly disciplines. Design-based research is one newer approach to education research that holds promise for developing effective interventions that are iteratively theorized, designed, and tested within local engineering education contexts. Purpose: To promote engagement with diverse research frameworks, the purpose of this narrative literature review was to identify, describe, and critically examine emerging use of design-based research in engineering education. We addressed research questions focused on characterizing the use of design-based research in engineering education in terms of the a) problems studied, b) interventions designed, c) participant populations and learning contexts, d) research methods employed, e) form(s) of the research findings, and f) limitations of the literature. Furthermore, this work identified current opportunities and challenges of design-based research for the field of engineering education through analysis of review findings in light of the authors' experiences conducting design-based research in engineering education. Scope/Method: Using established review procedures that included specified database search terms and inclusion criteria, we identified 24 empirical design-based research studies in engineering education. We used qualitative content analysis to code study characteristics including nationality, participant population, research methods, and learning context. We then synthesized and critiqued findings across studies. Conclusions: In synthesizing key aspects of empirical design-based research studies in engineering education, this review provides insights into the ways design-based research is being implemented to advance engineering education imperatives and provides a foundation for expanding and strengthening use of design-based research in future work in engineering education. Opportunities of design-based research for engineering education include developing local improvements to the field's most persistent and vexing issues (i.e., "wicked" problems) and realizing the full potential of technology for 21st century engineering education. Challenges include developing interdisciplinary teams, the need for expertise across multiple research approaches and methods, funding emergent DBR projects, and disseminating DBR results across the project lifespan.