Promotion of Full‐Thickness Wound Healing Using Epigallocatechin‐3‐<scp><i>O</i></scp>‐Gallate/Poly (Lactic‐<scp>C</scp>o‐<scp>G</scp>lycolic Acid) Membrane as Temporary Wound Dressing

Kim, Hye Lee; Lee, Jeong Hyun; Kwon, Byeong Ju; Lee, Mi Hee; Han, Dong‐Wook; Hyon, Suong Hyu; Park, Jong Chul

doi:10.1111/aor.12190

Cited by 34 publications

(28 citation statements)

References 20 publications

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“…This factor is recognized as the strongest contributor to angiogenesis (Kapoor, Howard, Hall, & Appleton, ). Kim et al () found that the membranes containing EGCG can accelerate wound healing by the proliferation of epithelial cells and the formation of new capillaries (Kim et al, ).…”

Section: Discussionmentioning

confidence: 99%

The effect of green tea ointment on episiotomy pain and wound healing in primiparous women: A randomized, double‐blind, placebo‐controlled clinical trial

Shahrahmani

Kariman

Jannesari

et al. 2017

Phytotherapy Research

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The delayed healing of episiotomy wound and its associated pain is a major problem in obstetrics. Because green tea has analgesic and wound-healing properties, the present study was conducted to determine the effect of green tea ointment on episiotomy pain and wound-healing. The green tea extract was also standardized by measuring its Phenolic and flavonoid compounds, antioxidant activity, and one of its active components, that is, Epigallocatechin gallate. The present clinical trial was conducted on 99 primiparous women visiting Afzalipour Hospital in Kerman in 2015. The subjects were randomly divided into 3 groups, including a green tea ointment group, a placebo ointment group, and a routine care group. The 2 ointment groups smeared 2 cm of the green tea or placebo ointments onto their sutured area twice daily for a total of 10 days. The severity of pain was assessed in the subjects using the visual pain scale and wound-healing using the Redness, Edema, Ecchymosis, Discharge, Approximation (REEDA) scale before the intervention and on the 5th and 10th days after delivery. To standardize the extract, Epigallocatechin gallate was measured by high-performance liquid chromatography (HPLC). Phenolic and flavonoid compounds, as well as antioxidant activity of the extract were also determined by spectrometry methods. Before the intervention, no significant differences were observed between the 3 groups in terms of their personal and obstetric details (p > .05), the severity of pain (p = .118), and the REEDA score (p = .212). On the 5th and 10th days after delivery, the severity of pain was significantly lower in the green tea group than in the other 2 groups (p < .0001). The mean REEDA score on the 5th and 10th days showed a better and faster healing in the green tea group compared to the other 2 groups (p < .0001). Total content of phenolic and flavonoids contents of green tea were 74.2 mg/g Gallic acid equivalent and 16.3 mg/g Rutin equivalent, respectively, and its antioxidant capacity was 46% of b-carotene. Green tea ointment appears to be effective in relieving episiotomy pain and improving wound-healing in this study. Further studies are recommended to be conducted on the effectiveness and safety of the different doses of green tea ointment.

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Section: Discussionmentioning

confidence: 99%

The effect of green tea ointment on episiotomy pain and wound healing in primiparous women: A randomized, double‐blind, placebo‐controlled clinical trial

Shahrahmani

Kariman

Jannesari

et al. 2017

Phytotherapy Research

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“…PLGA electrospun membranes containing Epigallocatechin‐3‐O‐gallate exhibited faster wound healing in full‐thickness wounds created in nude mice. The underlying mechanisms include enhanced cell infiltration, reepithelialization, and angiogenesis PLGA‐metformin electrospun nanofibrous membranes improved wound healing and reepithelialization in diabetic rats relative to the respective controls . The same group also reported that electrospun nanofibrous metformin‐loaded collagen/PLGA scaffold membranes were more hydrophilic than collagen/PLGA membranes and exhibited a greater water‐containing capacity.…”

Section: Poly(lactic‐co‐glycolic Acid)mentioning

confidence: 94%

PLGA based drug delivery systems: Promising carriers for wound healing activity

Chereddy

Vandermeulen

Préat

2016

Wound Repair Regeneration

170

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Wound treatment remains one of the most prevalent and economically burdensome healthcare issues in the world. Current treatment options are limited and require repeated administrations which led to the development of new therapeutics to satisfy the unmet clinical needs. Many potent wound healing agents were discovered but most of them are fragile and/or sensitive to in vivo conditions. Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer approved by food and drug administration and European medicines agency as an excipient for parenteral administrations. It is a well-established drug delivery system in various medical applications. The aim of the current review is to elaborate the applications of PLGA based drug delivery systems carrying different wound healing agents and also present PLGA itself as a wound healing promoter. PLGA carriers encapsulating drugs such as antibiotics, anti-inflammatory drugs, proteins/peptides, and nucleic acids targeting various phases/signaling cycles of wound healing, are discussed with examples. The combined therapeutic effects of PLGA and a loaded drug on wound healing are also mentioned.

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“…Wound dressings play an important part in the treatment of DFUs, and different dressings are used depending on the stage and type of DFU, based on the extent of injury, patient condition and tissues involved [29,30]. Many dermal replacements can improve diabetic wound healing, such as hyaluronic acid/PLGA core/shell fibre matrices [31] and epigallocatechin-3-O-gallate/PLGA [32]. Previously, we showed that PLGA/CNC nanofiber membranes can act as dermal regeneration templates and have better cytocompatibility than do PLGA nanofiber membranes.…”

Section: Discussionmentioning

confidence: 99%

Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

Zheng

Liu

Huang

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Diabetic foot ulcers (DFUs) are a threat to human health and can lead to amputation and even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found to be beneficial for diabetic wound healing. As we demonstrated previously, polylactide-polyglycolide (PLGA) and cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility and facilitate fibroblast adhesion, spreading and proliferation. PLGA/CNC nanofiber membranes are novel materials that have not been used previously as NT carriers in diabetic wounds. This study aims to explore the therapeutic efficacy and possible mechanisms of NT-loaded PLGA/CNC nanofiber membranes in full-thickness skin wounds in spontaneously diabetic mice. The results showed that NT could be sustained released from NT-loaded PLGA/CNC composite nanofiber membranes for 2 weeks. NT-loaded PLGA/CNC composite nanofiber membranes induced more rapid healing than other control groups. After NT exposure, the histological scores of the epidermal and dermal regeneration and the ratios of the fibrotic area to the whole area were increased. NT-loaded PLGA/CNC composite nanofiber membranes also decreased the expressions of the inflammatory cytokines IL-1β and IL-6. These results suggest that NT-loaded PLGA/CNC composite nanofiber membranes for sustained delivery of NT should effectively promote tissue regeneration for the treatment of DFUs.

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Promotion of Full‐Thickness Wound Healing Using Epigallocatechin‐3‐O‐Gallate/Poly (Lactic‐Co‐Glycolic Acid) Membrane as Temporary Wound Dressing

Cited by 34 publications

References 20 publications

The effect of green tea ointment on episiotomy pain and wound healing in primiparous women: A randomized, double‐blind, placebo‐controlled clinical trial

The effect of green tea ointment on episiotomy pain and wound healing in primiparous women: A randomized, double‐blind, placebo‐controlled clinical trial

PLGA based drug delivery systems: Promising carriers for wound healing activity

Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing

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