Promotion of Graft Survival by Photothrombotic Occlusion of Corneal Neovascularization

Corrent, George F.

doi:10.1001/archopht.1989.01070020575043

Cited by 39 publications

(17 citation statements)

References 20 publications

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“…Corrent et al [22] animals, preferred to irradiate the retinal vessels reported the occlusion of rabbit cornea neovascu- invagination of the basal membrane (big arrow) can be seen. lu = vascular lumen; cf = collagen fibers (uranil acetate and lead citrate; original magnification x 5,000).…”

Section: Discussionmentioning

confidence: 40%

Phthalocyanine mediated photodynamic thrombosis of experimental corneal neovascularization: Effect of phthalocyanine dose and irradiation onset time on vascular occlusion rate

et al. 1994

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The aim of this study was to evaluate the possible influence of phthalocyanine dose and of time interval between phthalocyanine injection and irradiation commencement on the rate of experimental corneal neovascularization photodynamic thrombosis in albino rabbits. New corneal vessels were irradiated with a diode laser (670 nm, 2 mW) after the intravenous injection of chloroaluminum sulfonated phthalocyanine. Different animals were irradiated either 5 min after the injection of different phthalocyanine doses (3, 6, 8, 12, or 14 mg/kg), or at different times (5 min, 24 h, or 58 h) after a standard phthalocyanine dose (3 mg/kg) injection. Irradiation time necessary for vascular occlusion was recorded. Decrease of phthalocyanine dose as well as delay of irradiation onset resulted in a statistically significant increase of irradiation time. Electron and light histological examination revealed platelet thrombi inside irradiated corneal new vessels. Damage in the vascular endothelial cell membrane and in intercellular contact structure was noted, leading to disorganization of the endothelial cells layer and death of most endothelial cells. These results indicate that both early commencement of irradiation after phthalocyanine injection and phthalocyanine dose increase accelerate the rate of phthalocyanine mediated corneal neovascularization photodynamic thrombosis. Thrombosis seems to result from photochemically induced vascular endothelial cell damage.

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Section: Discussionmentioning

confidence: 40%

Phthalocyanine mediated photodynamic thrombosis of experimental corneal neovascularization: Effect of phthalocyanine dose and irradiation onset time on vascular occlusion rate

et al. 1994

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“…Corneal NV models based on sutures are created using interrupted sutures placed at midstromal depth and perpendicular to the limbus, inducing a peripheral corneal vascularization [15,16,18] . With the information available from previous studies, it is difficult to assess the reliability and reproducibility of these experimental models in basal conditions, precluding any definitive conclusions.…”

Section: Discussionmentioning

confidence: 46%

“…Other corneal angiogenesis models in rabbits have also been described, which evaluate both the vascular and the inflammatory corneal response after an external aggression. These models include intrastromal injections of substances [9,10] , chemical injuries [11][12][13][14] and sutures [15][16][17][18] ( table 1 ). Most of these models are, however, unreliable or elicit a limited neovascular response.…”

Section: Introductionmentioning

confidence: 43%

New Corneal Neovascularization Model in Rabbits for Angiogenesis Research

et al. 2010

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Purpose: To evaluate a new experimental model of suture-induced corneal neovascularization (NV) for angiogenesis research. Methods: The new model was created in the right eye of 20 New Zealand rabbits using 5 interrupted silk sutures following an inverted triangle pattern. At different time points after suture placement, calibrated photographs were taken to quantify the corneal surface covered by the sutures (SCS) and the corneal NV response. At the end of the experiment, the corneas were processed for histological study. Results: Vascular sprouts were already observed on the 3rd day. On the 7th day, the mean corneal NV surface was 19.02 ± 4.65 mm². On the 14th day, the mean corneal NV surface increased up to 28.96 ± 6.33 mm², representing 112.18% of the SCS and 21.04% of the total corneal surface. Histological sections showed that the new vessels were located at the two anterior thirds of the corneal stroma with an intense inflammatory infiltration. Conclusion: Our results indicate that this experimental model is effective, reliable and reproducible to induce corneal NV for angiogenesis research.

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“…In the field of ophthalmology as well, the occlusive effect of PDT on ocular vessels has been obtained through thrombus formation (Royster et al, 1988 ;Kliman et al, 1994b ;Schmidt-Erfurth et al, 1994 ;Peyman et al, 1997). This finding led to the attempt to apply PDT to the treatment of ocular diseases associated with neovascularization in the cornea (Huang et al, 1989 ;Corrent et al, 1989 ;Pallikaris et al, 1993 ;Tsilimbaris et al, 1994 ;Schmidt-Erfurth et al, 1995 ;Obana et al, 1996 ;Soliman et al, 1997), iris (Packer et al, 1984 ;Miller et al, 1991), subretina (Thomas and Langhofer, * Correspondence and requests for reprints should be addressed to: Yuko Gohto, Department of Ophthalmology, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.…”

Section: Introductionmentioning

confidence: 44%

“…Several first-generation photosensitizers including rose bengal (Royster et al, 1988 ;Huang et al, 1989 ;Corrent et al, 1989) and dihematoporphyrin ether\ ester (Packer et al, 1984, Obana et al, 1996 were developed, but proved to be inappropriate for the clinical use because of either prolonged cutaneous photosensitivity resulting from slow-rate excretion or low photodynamic activity. Recently, Sakata et al synthesized a water-soluble photosensitizer ATX-S10 with a longer absorption wavelength, greater absorption efficiency, lower skin photosensitivity, stronger photooxygenation activities and a higher value of LD &!…”

Section: Introductionmentioning

confidence: 45%

Photodynamic Effect of a New Photosensitizer ATX-S10 on Corneal Neovascularization

Gohto

Obana

Kaneda

et al. 1998

Experimental Eye Research

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Promotion of Graft Survival by Photothrombotic Occlusion of Corneal Neovascularization

Cited by 39 publications

References 20 publications

Phthalocyanine mediated photodynamic thrombosis of experimental corneal neovascularization: Effect of phthalocyanine dose and irradiation onset time on vascular occlusion rate

Phthalocyanine mediated photodynamic thrombosis of experimental corneal neovascularization: Effect of phthalocyanine dose and irradiation onset time on vascular occlusion rate

New Corneal Neovascularization Model in Rabbits for Angiogenesis Research

Photodynamic Effect of a New Photosensitizer ATX-S10 on Corneal Neovascularization

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