Promotion of hair growth by newly synthesized ceramide mimetic compound

Park, Bu-Mahn; Bak, Soon‐Sun; Shin, Kyung-Oh; Kim, Minhee; Kim, Dae-Hwan; Jung, Sang‐Hun; Jeong, Sekyoo; Sung, Young Kwan; Kim, Hyun Jung

doi:10.1016/j.bbrc.2017.07.069

Cited by 9 publications

(19 citation statements)

References 13 publications

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“…Several peptide complexes, proteins and mimetics have also displayed significant hair growth potential in DPCs . Squarticles are the nanoparticles formed from sebum‐derived lipids such as squalene and fatty esters to achieve targeted drug delivery to the follicles.…”

Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

126

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

126

View full text Add to dashboard Cite

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“…To assess cellular sphingolipid levels, cells were harvested and lysed in RIPA buffer, followed by extraction of sphingolipids, as reported previously (Park et al, 2013(Park et al, , 2017. Extracted lipids dried using a vacuum system (Vision, Seoul, Korea) were redissolved in methanol and analyzed by liquid chromatographyelectrospray ionization-tandem-mass spectrometry (API 3200 QTRAP mass; AB/SCIEX, Concord, ON, Canada) by selective ion monitoring mode.…”

Section: Sphingolipid Analysis By Liquid Chromatography Tandem-mass Smentioning

confidence: 99%

Adiponectin Enhances Human Keratinocyte Lipid Synthesis via SIRT1 and Nuclear Hormone Receptor Signaling

Hong

Seo

Shin

et al. 2019

Journal of Investigative Dermatology

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Adiponectin is known to have beneficial effects on lipid and insulin metabolism, wound healing, and cellular senescence, but its effect on skin barrier formation remains unknown. We investigated the effects of adiponectin on keratinocyte lipid synthesis with respect to skin barrier function. Lipid staining revealed an adiponectinmediated increase in keratinocyte intracellular and reconstructed epidermal lipid content. Moreover, significant increases in the levels of ceramide and its downstream metabolites (sphingosine and sphingosine-1-phosphate) following adiponectin stimulation were detected using liquid chromatographyemass spectrometry. Expression levels of keratinocyte differentiation markers were also increased. Adiponectin also increased expression of lipid biosynthesis enzymes (fatty acid synthase, HMG-CoA reductase, and serine palmitoyltransferase), nuclear hormone receptors (peroxisome proliferatoreactivated receptors and liver X receptors), and the adiponectin signal molecule SIRT1. Suppression of SIRT1, liver X receptor-a, or peroxisome proliferatoreactivated receptor-a downregulated the expression of lipid synthetic enzymes, decreasing lipid content. Inhibition of adiponectin receptors decreased expression of nuclear hormone receptors, SIRT1, lipid-synthesizing enzymes, and sphingolipids. Thus, activation of adiponectin signaling increases the expression of transcription factors, including SIRT1, liver X receptor-a, and peroxisome proliferatoreactivated receptor-a, enhancing lipid synthesis and keratinocyte cell differentiation and possibly aiding in the maintenance of skin barrier homeostasis.

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“…Various plant extracts and chemicals with hair-growth-stimulating effects have been reported. Although precise underlying mechanisms remain unknown, these extracts and chemicals are considered to elicit these effects by accelerating blood flow, inducing a shift from telogen to anagen, mediating activation of the dermal papilla, inhibiting dihydrotestosterone, and exerting anti-inflammatory effects ( Junlatat and Sripanidkulchai, 2014 ; Kim et al, 2014 ; Park et al, 2017 ; Shen et al, 2018 ; Zhang et al, 2019 ; Zhou et al, 2020 ). The hair follicle contains several different types of cells; among these, the dermal papilla cells are major components of hair that play a critical role in inducing anagen phase and maintaining hair growth.…”

Section: Discussionmentioning

confidence: 99%

Fisetin Promotes Hair Growth by Augmenting TERT Expression

Kubo

Ogawa

Uehara

et al. 2020

Front. Cell Dev. Biol.

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Although thinning hair and alopecia are not recognized as severe diseases, hair loss has implications for mental health and quality of life; therefore, a large number of studies have been carried out to develop novel hair growth agents. In the present study, we aimed to examine the potential of telomerase reverse transcriptase (TERT), because TERT overexpression in skin activates resting hair follicle bulge stem cells, which triggers initiation of a new hair follicle growth phase and promotes hair synthesis. To this end, we screened polyphenols that activate TERT expression in keratinocytes, and identified resveratrol and fisetin as strong hTERT-augmenting compounds. These polyphenols also regulated the gene expression of cytokines such as IGF-1 and KGF, which activate the β-catenin pathway, and TGF-β1, which plays an important role in maintaining the niche of hair follicle stem cells, thus are thought to play roles in promoting hair growth. We additionally showed that these polyphenols, especially fisetin, promoted hair growth from the shaved dorsal skin of mice, which suggests that these polyphenols activate the transition from telogen to anagen phase. Histological studies indicated that the dorsal skin of mice treated with these polyphenols contained numerous hair follicles and was thickened compared with that in control mice. Furthermore, on the dorsal skin of mice treated with resveratrol and fisetin, a number of proliferating cells (Ki67 + cells) were observed around the hair papilla. These results suggest that resveratrol and fisetin induce a shift from telogen to anagen in the hair follicle by inducing proliferation of hair follicle bulge stem cells, thus promoting hair growth.

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Promotion of hair growth by newly synthesized ceramide mimetic compound

Cited by 9 publications

References 13 publications

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Adiponectin Enhances Human Keratinocyte Lipid Synthesis via SIRT1 and Nuclear Hormone Receptor Signaling

Fisetin Promotes Hair Growth by Augmenting TERT Expression

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