Promotion of right ventricular outflow tract reconstruction using a novel cardiac patch incorporated with hypoxia-pretreated urine-derived stem cells

Zhao, Lu; Wang, Long; Zhang, Wenqian; Wang, Rui; Zhang, Xiuzhen; Lei, Xiongxin; Liang, Yan; Song, Yuting; Zhang, Qingyi; Lin, Kan; Xie, Huiqi

doi:10.1016/j.bioactmat.2021.11.021

Cited by 8 publications

(8 citation statements)

References 66 publications

(84 reference statements)

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“…The SIS and PU/SIS composites were prepared with a previously described method, and the PU/SIS composites with excellent mechanical strength was screened ( 12 , 13 ). The thicknesses of the SIS and PU/SIS layers were approximately 100 and 300 μm, which have matched with that of the endometrium and myometrium of rat uterus, respectively (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The SIS and PU/SIS were prepared with our previously described methods ( 12 , 13 ), which is described in detail in the Supplementary Materials. The prepared SIS and the PU/SIS were respectively cut into squares with a size of 20 × 20 mm and quadrangles with a length of 20 mm and a thickness of 300 μm.…”

Section: Methodsmentioning

confidence: 99%

“…In our previous study, polyurethane/SIS (PU/SIS), a hybrid composite with good compatibility and adjustable mechanical properties, was prepared ( 12 , 13 ). It was suitable for the repair of soft tissues with supportive and/or contractile properties such as bladder, esophagus, uterus, urethra, etc.…”

Section: Introductionmentioning

confidence: 99%

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Promotion of uterine reconstruction by a tissue-engineered uterus with biomimetic structure and extracellular matrix microenvironment

Zhao,

Da,

Wang

et al. 2023

Sci. Adv.

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The recurrence rate for severe intrauterine adhesions is as high as 60%, and there is still lack of effective prevention and treatment. Inspired by the nature of uterus, we have developed a bilayer scaffold (ECM-SPS) with biomimetic heterogeneous features and extracellular matrix (ECM) microenvironment of the uterus. As proved by subtotal uterine reconstruction experiments, the mechanical and antiadhesion properties of the bilayer scaffold could meet the requirement for uterine repair. With the modification with tissue-specific cell–derived ECM, the ECM-SPS had the ECM microenvironment signatures of both the endometrium and myometrium and exhibited the property of inducing stem cell–directed differentiation. Furthermore, the ECM-SPS has recruited more endogenous stem cells to promote endometrial regeneration at the initial stage of repair, which was accompanied by more smooth muscle regeneration and a higher pregnancy rate. The reconstructed uterus could also sustain normal pregnancy and live birth. The ECM-SPS may thereby provide a potential treatment for women with severe intrauterine adhesions.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Promotion of uterine reconstruction by a tissue-engineered uterus with biomimetic structure and extracellular matrix microenvironment

Zhao,

Da,

Wang

et al. 2023

Sci. Adv.

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“…One-third of these cases exhibit life-threatening complications without surgical interventions early in life [ 7 , 8 ]. For those requiring surgery, implantation of patch material to augment hypoplastic or replace absent structures is common [ 9 ]. The ideal patch would repair or replace both the form and function of the deficient or malformed structure.…”

Section: Introductionmentioning

confidence: 99%

“…The archetype patch material must be strong enough to provide adequate suture retention and burst pressure, have favorable handling characteristics to allow for appropriate tissue reconstruction, and be non-thrombogenic while providing appropriate hemostasis. In the long term, it must elicit an immunologically favorable reaction devoid of a persistent foreign body response and lack of significant calcification, which can result in stenosis and reduced tissue elasticity [ 9 – 13 ]. Ideally, patch materials would allow for endothelization, native tissue ingrowth, neovascularization, and improve long-term remodeling to reduce the arrhythmogenic and infectious risks and allow for growth potential [ 9 , 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Patch Materials for Pulmonary Artery Arterioplasty and Right Ventricular Outflow Tract Augmentation: A Review

et al. 2023

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Patch augmentation of the right ventricular outflow tract (RVOT) and pulmonary artery (PA) arterioplasty are relatively common procedures in the surgical treatment of patients with congenital heart disease. To date, several patch materials have been applied with no agreed upon clinical standard. Each patch type has unique performance characteristics, cost, and availability. There are limited data describing the various advantages and disadvantages of different patch materials. We performed a review of studies describing the clinical performance of various RVOT and PA patch materials and found a limited but growing body of literature. Short-term clinical performance has been reported for a multitude of patch types, but comparisons are limited by inconsistent study design and scarce histologic data. Standard clinical criteria for assessment of patch efficacy and criteria for intervention need to be applied across patch types. The field is progressing with improvements in outcomes due to newer patch technologies focused on reducing antigenicity and promoting neotissue formation which may have the ability to grow, remodel, and repair.

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Emerging Design Strategies Toward Developing Next‐Generation Implantable Batteries and Supercapacitors

Peng

Wang

et al. 2023

Adv Funct Materials

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In recent years, the development of implantable bioelectronics has garnered significant attention. With the continuous advancement of IoT and information technology, implantable bioelectronics can be utilized more effectively for health monitoring to enhance treatment outcomes, reduce healthcare costs, and improve quality of life. Implantable energy storage devices have been widely studied as critical components for energy supply. Conventional power sources are bulky, inflexible, and potentially contain materials that are dangerous to the body. Meanwhile, human tissues are soft, flexible, dynamic, and closed, which puts new requirements on energy storage devices to improve the safety, stability, and matching of implantable batteries or supercapacitors. Herein, recent advances in state‐of‐the‐art nonconventional power options for implantable electronics, specifically biocompatible, miniaturized, stretchable/deformable, biodegradable/bioresorbable, edible, and injectable energy storage devices, are reviewed in this paper. The material strategy and architectural design of the next‐generation implantable energy storage device are discussed, including the selection principle of electrolytes, the all‐in‐one structure design strategy, and the way to realize self‐charging. Finally, the challenges and prospects of emerging design strategies toward developing next‐generation implantable batteries and supercapacitors for the future are put forward.

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Promotion of right ventricular outflow tract reconstruction using a novel cardiac patch incorporated with hypoxia-pretreated urine-derived stem cells

Cited by 8 publications

References 66 publications

Promotion of uterine reconstruction by a tissue-engineered uterus with biomimetic structure and extracellular matrix microenvironment

Promotion of uterine reconstruction by a tissue-engineered uterus with biomimetic structure and extracellular matrix microenvironment

Patch Materials for Pulmonary Artery Arterioplasty and Right Ventricular Outflow Tract Augmentation: A Review

Emerging Design Strategies Toward Developing Next‐Generation Implantable Batteries and Supercapacitors

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