Promotion properties of TLR7 in pediatric meningitis via the NF-κB pathway

He, Yejun; Zhang, Xianhua; Sun, Ying; Gong, Ping; Yu, Hong

doi:10.1007/s10863-020-09862-4

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…In contrast, in patients and mice with pneumococcal meningitis, TLR7 was overexpressed. The TLR7 overexpression-induced model showed NF-κB activation and proinflammatory cytokine production, while TLR7 silencing suppressed inflammatory reactions and apoptosis and promoted cell viability, reducing brain damage caused by meningitis in mice [ 143 ].…”

Section: Involvement Of Tlrs In Neuroinflammation and Neurodegenerationmentioning

confidence: 99%

From Immunity to Neurogenesis: Toll-like Receptors as Versatile Regulators in the Nervous System

Abarca-Merlin,

Martínez-Durán,

Medina-Pérez

et al. 2024

IJMS

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Toll-like receptors (TLRs) are among the main components of the innate immune system. They can detect conserved structures in microorganisms and molecules associated with stress and cellular damage. TLRs are expressed in resident immune cells and both neurons and glial cells of the nervous system. Increasing evidence is emerging on the participation of TLRs not only in the immune response but also in processes of the nervous system, such as neurogenesis and cognition. Below, we present a review of the literature that evaluates the expression and role of TLRs in processes such as neurodevelopment, behavior, cognition, infection, neuroinflammation, and neurodegeneration.

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Section: Involvement Of Tlrs In Neuroinflammation and Neurodegenerationmentioning

confidence: 99%