Promotor hypermethylated genes: Prospective diagnostic biomarkers in oral cancerogenesis

Dvojakovska, Suzana; Popovic-Monevska, Danica; Grcev, A.; Pancevski, Goran; Benedetti, A; Popovski, V.; Dimovski, Aleksandar; Stamatoski, Aleksandar

doi:10.1016/j.jcms.2018.07.019

Cited by 10 publications

(26 citation statements)

References 15 publications

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“…Biochemical Genetics (2020) 58:213-244 and meta-analyses (Sanchez-Cespedes et al 2000;Don et al 2014;Choudhury and Ghosh 2015;Sushma et al 2016;Dvojakovska et al 2018;Alsofyani et al 2017;Veeramachaneni et al 2019). Allameh et al (2018) reported a higher methylation level of its promoter in OSCC patients compared to a control group, and hypermethylation was associated with lower expression of that gene in tumor samples.…”

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confidence: 99%

“…The gene MGMT (O6-methylguanine-DNA methyltransferase) is related to DNA repair, and increased methylation in its promoter has been reported in HNSCC (Koutsimpelas et al 2012;Chaisaingmongkol et al 2012;Dvojakovska et al 2018). In a meta-analysis based on 20 studies, the promoter of MGMT was hypermethylated in HNSCC compared to healthy controls, suggesting a connection between higher methylation and an increased risk of head and neck cancer (Cai et al 2016).…”

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confidence: 99%

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Epigenetic Modifications in Head and Neck Cancer

et al. 2019

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human malignancy in the world, with high mortality and poor prognosis for patients. Among the risk factors are tobacco and alcohol intake, human papilloma virus, and also genetic and epigenetic modifications. Many studies show that epigenetic events play an important role in HNSCC development and progression, including DNA methylation, chromatin remodeling, histone posttranslational covalent modifications, and effects of non-coding RNA. Epigenetic modifications may influence silencing of tumor suppressor genes by promoter hypermethylation, regulate transcription by microRNAs and changes in chromatin structure, or induce genome instability through hypomethylation. Moreover, getting to better understand aberrant patterns of methylation may provide biomarkers for early detection and diagnosis, while knowledge about target genes of microRNAs may improve the therapy of HNSCC and extend overall survival. The aim of this review is to present recent studies which demonstrate the role of epigenetic regulation in the development of HNSCC.

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Epigenetic Modifications in Head and Neck Cancer

et al. 2019

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“…Oral squamous cell carcinoma (OSCC) is one of the most common cancers of the oral cavity [1]. It accounts for 96% of all head and neck cancers [2]. 100,000 patients die annually from OSCC and the incidence is increasing to 500,000 worldwide [2].…”

Section: Introductionmentioning

confidence: 99%

“…It accounts for 96% of all head and neck cancers [2]. 100,000 patients die annually from OSCC and the incidence is increasing to 500,000 worldwide [2]. With all the innovations in diagnosing and treating OSCC, a percentage of 50% and more of patients suffer from relapse and increased mortality rate [2].…”

Section: Introductionmentioning

confidence: 99%

“…100,000 patients die annually from OSCC and the incidence is increasing to 500,000 worldwide [2]. With all the innovations in diagnosing and treating OSCC, a percentage of 50% and more of patients suffer from relapse and increased mortality rate [2]. Different endogenous and environmental risk factors related to OSCC were discussed in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Insights into Epigenetics Mechanisms in Oral Squamous Cell Carcinoma

Alothman¹,

Alsenani²,

Alrabiah³

et al. 2020

SJODR

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Oral squamous cell carcinoma (OSCC) is one of the most common oral cancers accounting for 96% of all head and neck cancers. Beside the different endogenous and environmental risk factors, epigenetics play an important role in causing OSCC. Epigenetics shed light on the presence of inherited changes in the phenotype of a gene with the absence of an alteration in the DNA sequence. The epigenetic modifications can result in the emersion of cancer, autoimmune diseases, aging and other diseases. Under several circumstances, DNA undergoes methylation. This methylation might be related to normal development or serious diseases like cancer. DNA methylation is a heritable biochemical modification occurs predominantly by transferal of a methyl group to C-5 position of the cytosine ring (CpGs) which may cause epigenetic disturbances. This review aims toward investigating the genetics in literature to help in diagnosing OSCC with new modalities that are less invasive compared to histopathology. Studied genes including ECAD, DAPK, MGMT and P53 has different methylation frequencies in relation to OSCC which may be related to their significant role in early diagnosis and prognosis. Since genetics has a major role in OSCC, we searched most recently reported genes and technologies seeking early detection and treatment of OSCC results in a better prognosis and more conservative treatment.

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Oral cancer: Recent breakthroughs in pathology and therapeutic approaches

Ramachandran

2024

Oral Oncology Reports

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Promotor hypermethylated genes: Prospective diagnostic biomarkers in oral cancerogenesis

Cited by 10 publications

References 15 publications

Epigenetic Modifications in Head and Neck Cancer

Epigenetic Modifications in Head and Neck Cancer

Insights into Epigenetics Mechanisms in Oral Squamous Cell Carcinoma

Oral cancer: Recent breakthroughs in pathology and therapeutic approaches

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