Prompt gamma ray imaging for verification of proton boron fusion therapy: A Monte Carlo study

Shin, Han-Back; Yoon, Do-Kun; Jung, Jin‐Woo; Kim, Moo-Sub; Suh, Tae Suk

doi:10.1016/j.ejmp.2016.05.053

Cited by 22 publications

(21 citation statements)

References 22 publications

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“…Moreover, the ballistic properties of the incident proton beam, whereby proton energies drastically decrease in correspondence with the tumour volume, ensure negligible nuclear fusion events even in the worst-case scenario where the delivery agent containing 11 B nuclei is also heavily present in the healthy tissues surrounding the tumour. Furthermore, the presence of 10 B in the proposed method allows triggering various nuclear reactions that generate prompt γ-rays, thus being potentially useful for a simultaneous treatment-and-diagnostics approach 32,43,59 .…”

Section: Discussionmentioning

confidence: 99%

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

Cirrone

Manti

Margarone

et al. 2018

Sci Rep

104

154

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Protontherapy is hadrontherapy’s fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy’s superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) 12C-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper 12C-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + 11B → 3α reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses 10B-enriched BSH for neutron irradiation-triggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy’s ballistic precision with the higher RBE promised by BNCT and 12C-ion therapy is thus demonstrated.

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Section: Discussionmentioning

confidence: 99%

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

Cirrone

Manti

Margarone

et al. 2018

Sci Rep

104

154

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“…The first publication on BPC in radiation therapy used Monte Carlo simulations and showed an enhanced high dose in the areas where the boron uptake coincided with the Bragg peak (5). There are a few other studies which used Monte Carlo simulations, but which produced highly divergent results on the potentially achievable BPC dose, ranging from 0.026% to 0.3% based on using different proton energies and 11 B concentrations (5)(6)(7)(8). The first cell culture experiments were performed at the medical cyclotron in Catania and showed that the BPC procedure increased the biological effectivity of proton irradiation (9).…”

Section: Boron Proton Capturementioning

confidence: 99%

“…The highest probability for the most effective combination of BPC and proton dose occurs at a discrete proton energy level of 675 keV (5)(6)(7)(8)(9). Accessing this energy requires an initial proton deceleration to a certain position along the proton dose-depth curve (under the Bragg peak or at the end of the spread of the Bragg peak) and thus the BPC reaction can be defined with submillimeter accuracy.…”

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confidence: 99%

¹¹Boron Delivery Agents for Boron Proton-capture Enhanced Proton Therapy

et al. 2019

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The aim of this review was to define appropriate 11 B delivery agents for boron proton-capture enhanced proton therapy (BPCEPT) taking into account the accumulated knowledge on boron compounds used for boron neutron capture therapy (BNCT). BPCEPT is a promising treatment approach which uses a high linear energy transfer (LET) dose component in conjunction with conventional proton therapy to increase the relative biological effectiveness of highly-selective charged particle therapy. Boron proton fusion reactions occur with highest cross section at certain proton energy level and thus can be tailored to the target volume with careful treatment planning that defines the 675 MeV proton distribution with high accuracy. Appropriate 11 B compounds are required in order to achieve relevant high LET dose contribution from the boron proton-capture reaction. Previous scientific results and experiences with BNCT provide background knowledge and information regarding the optimization of boronated compound development, their characterization, measurement and imaging. However, there are substantial differences between BNCT and BPCEPT, which in turn places special unique chemical, physical and biological demands on 11 B-carrier compounds for BPCEPT. In this review, we evaluate well-known and recently developed boron compounds for BPCEPT.

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“…Recently, particle therapy techniques using boron compounds, such as the boron neutron capture therapy (BNCT) method, have been progressed to improve therapeutic effects in particle radiation therapy [ 4 – 6 ]. Moreover, a prompt gamma ray induced by a reaction between the particle and boron can provide prompt gamma ray image during treatment [ 7 , 8 ]. In particular, proton boron fusion therapy (PBFT) has been suggested as a novel radiation therapy technique and tumor monitoring technique for use during treatment.…”

Section: Introductionmentioning

confidence: 99%

“…In particular, proton boron fusion therapy (PBFT) has been suggested as a novel radiation therapy technique and tumor monitoring technique for use during treatment. The PBFT method is a treatment technique based on the proton-boron fusion reaction [ 6 , 8 ]. The proton captures 11-boron ( 11 B), resulting in three alpha particles (one 3.76 MeV, two 2.46 MeV) and a 719 keV prompt gamma ray [ 6 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of prompt gamma ray imaging during proton boron fusion therapy according to boron concentration

Shin

Kim

et al. 2017

Oncotarget

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The purpose of this study is to evaluate the prompt gamma ray imaging technique according to the clinical boron concentration range during proton boron fusion therapy (PBFT). To acquire a prompt gamma ray image from 32 projections, we simulated four head single photon emission computed tomography and a proton beam nozzle using a Monte Carlo simulation. We used modified ordered subset expectation maximization reconstruction algorithm with a graphic processing unit for fast image acquisition. Boron concentration was set as 20 to 100 μg at intervals of 20 μg. For quantitative analysis of the prompt gamma ray image, we acquired an image profile drawn through two boron uptake regions (BURs) and calculated the contrast value, signal-to-noise ratio (SNR), and difference between the physical target volume and volume of the prompt gamma ray image. The relative counts of prompt gamma rays were noticeably increased with increasing boron concentration. Although the intensities on the image profiles showed a similar tendency according to the boron concentration, the SNR and contrast value were improved with increasing boron concentration. This study suggests that a tumor monitoring technique using prompt gamma ray detection can be clinically applicable even if the boron concentration is relatively low.

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Prompt gamma ray imaging for verification of proton boron fusion therapy: A Monte Carlo study

Cited by 22 publications

References 22 publications

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

¹¹Boron Delivery Agents for Boron Proton-capture Enhanced Proton Therapy

Quantitative analysis of prompt gamma ray imaging during proton boron fusion therapy according to boron concentration

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Prompt gamma ray imaging for verification of proton boron fusion therapy: A Monte Carlo study

Cited by 22 publications

References 22 publications

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

11Boron Delivery Agents for Boron Proton-capture Enhanced Proton Therapy

Quantitative analysis of prompt gamma ray imaging during proton boron fusion therapy according to boron concentration

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¹¹Boron Delivery Agents for Boron Proton-capture Enhanced Proton Therapy