Pronounced differences in the frequency of TaqI βA‐inhibin alleles between sheep breeds with different reproductive performance

Leyhe, B.; Hiendleder, Stefan; Jaeger, C.; Wassmuth, R.

doi:10.1111/j.1365-2052.1994.tb00054.x

Cited by 9 publications

(14 citation statements)

References 17 publications

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“…Influence of variation in the inhibin gene on litter size of Merino and Friesian sheep at the level of, respectively, +0.04 and +0.09 lamb had been demonstrated previously [68]. The effect of TaqI/INHA polymorphism on the number of offspring has also been confirmed for Merino, East-Friesian and Romanowska breeds [69]. After comparing frequency of allele A in sheep with varying prolificacy, the above authors found that with increasing fertility, an increase in the frequency of allele A could be observed as well.…”

Section: G617a Polymorphism In Inhibin-α Gene (Inha)supporting

confidence: 59%

Genes Involved Litter Size in Olkuska Sheep

Kaczor¹

2017

Genetic Polymorphisms

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Major genes increasing litter size were identified in certain sheep breeds. These genes include BMPR-1B, BMP15, GDF9 and B4GALNT2, FecX2. Polish Olkuska sheep is a highfecundity sheep breed; while some animals might give birth to just one or two lambs, there are Olkuska ewes which have six or even seven lambs/lambing. Fertility of this breed is caused by mutation in the major gene FecX O (BMP15 gene), but analysis of polymorphism at the locus GDF9 revealed presence of four polymorphisms: G447A (L159L), A978G (G326G), G994A (V332I) and G1111A (V371M). Substitutions V371 and V332I are missense mutations found in the sequence encoding active GDF9 protein. V371 polymorphism has also an effect on litter size in Olkuska breed ewes. Study of genes associated with litter size in Olkuska sheep is of high importance, as they could be used in breeding programmes as selection markers for increasing production efficiency.

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Section: G617a Polymorphism In Inhibin-α Gene (Inha)supporting

confidence: 59%

Genes Involved Litter Size in Olkuska Sheep

Kaczor¹

2017

Genetic Polymorphisms

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“…Further validations were performed by qRT-PCR for 10 selected DEGs, such as inhibin, beta A (INHBA), zona pellucida glycoprotein 3 (ZP3), and hypoxia-inducible factor 1-alpha (HIF1A). Previous research showed that INHBA inhibited FSH secretion and activity in granulosa cells and INHBA gene mutations were associated with litter size in sheep [ 31 , 32 ]. In this study, the downregulated INHBA gene may contribute to an increase in FSH levels and facilitate follicular development in estrus porcine ovary.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the downregulated INHBA gene may contribute to an increase in FSH levels and facilitate follicular development in estrus porcine ovary. It has been reported that ZP3 functioned as the sperm receptor and mutations were associated with number of piglets born alive [ 32 , 33 ]. In addition, HIF1A is required for vascular endothelial growth factor A (VEGFA) mediated ovarian follicle development and survival [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Differentially Expressed Genes in Porcine Ovaries at Proestrus and Estrus Stages Using RNA-Seq Technique

Yang

Zhou

Pei

et al. 2018

BioMed Research International

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Estrus is an important factor for the fecundity of sows, and it is involved in ovulation and hormone secretion in ovaries. To better understand the molecular mechanisms of porcine estrus, the expression patterns of ovarian mRNA at proestrus and estrus stages were analyzed using RNA sequencing technology. A total of 2,167 differentially expressed genes (DEGs) were identified (P ≤ 0.05, |log2 Ratio| ≥ 1), of which 784 were upregulated and 1,383 were downregulated in the estrus compared with the proestrus group. Gene Ontology (GO) enrichment indicated that these DEGs were mainly involved in the cellular process, single-organism process, cell and cell part, and binding and metabolic process. In addition, a pathway analysis showed that these DEGs were significantly enriched in 33 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, including cell adhesion molecules, ECM-receptor interaction, and cytokine-cytokine receptor interaction. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) confirmed the differential expression of 10 selected DEGs. Many of the novel candidate genes identified in this study will be valuable for understanding the molecular mechanisms of the sow estrous cycle.

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“…INHA and INHbA genes are confirmed to be important candidate genes for prolificacy in sheep (Hiendleder et al 2002;Chu et al 2007). Leyhe et al (1994) showed that INHA gene had TaqI restriction fragment length polymorphism (RFLP), and TaqI A allele associated with average litter size in sheep breeds. Ma et al (2010) reported the genotype distributions of INHA gene were significantly different between year-round estrous goat breeds and seasonal estrous goat breeds, revealing the association to the prolificacy in goats.…”

Section: Discussionmentioning

confidence: 99%

“…INHA gene were associated with premature ovarian failure. The important roles of the INHA and INHbA genes in reproduction make it a strong candidate gene for multi-births in mammals such as sheep (Leyhe et al 1994;Wu et al 2009), as well as humans (Montgomery et al 2000) and pigs (Kim et al 2006). Based on the above considerations, we used DNA sequencing and polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis to investigate allelic variation in the 5′ promoter region of INHA gene and the exon 2 of INHbA gene.…”

Section: Introductionmentioning

confidence: 99%

Exploring polymorphisms and their effects on reproductive traits of the INHA and INHβA genes in three goat breeds

Hou

et al. 2011

Animal Science Journal

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In this study, we report the analysis of INHA and INHβA gene polymorphisms in 786 goats of three breeds: Xinong Saanen (SN), Guanzhong (GZ) and Boer (BG). We identified three new allelic variants: P1-C80G and/126G (GenBank accession no. HQ202573) in the three goat breeds and P2-C936T (GenBank accession no. HQ202572) in SN and GZ goat breeds. At P1 locus, AA, AB and BB genotypes were found in the three goat breeds. At P2 locus, CC and CT genotypes were found in SN and GZ goat breeds. After comparing genotype distribution within the three goat breeds, BG had conspicuous differences from SN and GZ (P < 0.001) at P2 locus. The SNP locus was in Hardy-Weinberg disequilibrium at P1 locus in the three goat breeds (P < 0.05). At P2 locus, the SNP locus was in Hardy-Weinberg disequilibrium in SN and GZ goat breeds (P < 0.05). Association of polymorphisms with litter size was done at P1 locus in the three goat breeds. The result showed that AA genotype had remarkable litter size at P1 locus in the three goat breeds (P < 0.05). Therefore, these results suggest that INHA gene is a strong candidate gene that affects litter size in goats.

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Pronounced differences in the frequency of TaqI βA‐inhibin alleles between sheep breeds with different reproductive performance

Cited by 9 publications

References 17 publications

Genes Involved Litter Size in Olkuska Sheep

Genes Involved Litter Size in Olkuska Sheep

Identification of Differentially Expressed Genes in Porcine Ovaries at Proestrus and Estrus Stages Using RNA-Seq Technique

Exploring polymorphisms and their effects on reproductive traits of the INHA and INHβA genes in three goat breeds

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