Proof of concept percutaneous treatment system to enable fast and finely controlled ablation of biological tissue

Hancock, Christopher P.; Chaudhry, Samena; Wall, Patrick M.; Goodman, Andrew M.

doi:10.1007/s11517-007-0184-z

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…The effectiveness of using microwave energy at 14.5 GHz for coagulating blood has been shown in [533]. Tumor vascularity in which cancerous cells make blood vessels is an important factor for tumors to become malignant.…”

Section: A Ablation and Catheter Ablationmentioning

confidence: 99%

Applications of Microwaves in Medicine

Chiao

Lin

et al. 2023

IEEE J. Microw.

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Advances and updates in medical applications utilizing microwave techniques and technologies are reviewed in this paper. The article aims to provide an overview of enablers for microwave medical applications and their recent progress. The emphasis focuses on the applications of microwaves, in the following order, for 1) signal and data communication for implants and wearables through the human body, 2) electromagnetic energy transfer through tissues, 3) noninvasive, remote or in situ physical and biochemical sensing, and 4) therapeutic purposes by changing tissue properties with controlled thermal effects. For signal and data communication and wireless power transfer, implant and wearable applications are discussed in the categories of pacemakers, endoscopic capsules, brain interfaces, intraocular, cardiac and intracranial pressure sensors, neurostimulators, endoluminal implants, artificial retina, smart lenses, and cochlear implants. For noninvasive sensing, remote vital sign radar, biological cell probing, magnetic resonance and microwave imaging, biochemical, blood glucose, hydration and biomarker sensing applications are introduced. For therapeutic uses, the developments of microwave ablation, balloon angioplasty, and hyperthermia applications are reviewed. The scopes of this article mainly concentrate on the research and development efforts in the past 20 years. Recent review articles on specific topics are cited with accomplishment highlights and trends deliberated. At the end of this article, a brief history of the IEEE Microwave Theory and Techniques Society (MTT-S) Biological Effects and Medical Applications committee and the contributions by its members to the promotion and advancement of microwave technologies in medical fields are chronicled.

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Section: A Ablation and Catheter Ablationmentioning

confidence: 99%

Applications of Microwaves in Medicine

Chiao

Lin

et al. 2023

IEEE J. Microw.

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“…The design of the system has been reported previously [10]. Power and duration of ablation were programmed into the MicroBlate system, which was activated by a foot pedal.…”

Section: Ablation Protocolmentioning

confidence: 99%

“…Phase and magnitude information are extracted using a double heterodyne detector that down-converts the 14.5 GHz signal to a 10 MHz measurement signal that still contains the necessary tissue impedance information, but can be processed using a standard digital to analogue (DAC) converter and microprocessor/digital signal processing unit. This phase and magnitude information is used to calculate the movement of actuators contained within a triple stub tuning network to ensure that the impedance of the generator is matched to the impedance of the biological tissue load, ensuring that the power available at the output of the source (less the insertion loss of the low loss microwave cable and the insertion loss of the applicator shaft) is transferred into the tumour or other biological tissue in contact with the tip of the applicator [10]. In essence, a resonant tuning cavity is created using the triple stub tuning network, the low loss co-axial cable and the antenna.…”

Section: Introductionmentioning

confidence: 99%

“…Previous work has demonstrated that 14.5 GHz is an optimum frequency for high power ablation and low power measurement [10][11][12]. The limited depth of the microwave field (defined as the distance into tissue at which the value of the electric field has decreased to 37% of its maximal or initial value) at 14.5 GHz ensures that the phase and magnitude of the reflected signal is due to the tissue directly at the antenna tip and adjacent tissue causes minimal perturbations..…”

Section: Introductionmentioning

confidence: 99%

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Microwave ablation ofex vivohuman liver and colorectal liver metastases with a novel 14.5 GHz generator

Jones

Kitteringham

Terlizzo

et al. 2012

International Journal of Hyperthermia

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Purpose: This study assessed the relationship between time, power and ablation size using a novel high-frequency 14.5 GHz microwave applicator in ex vivo human hepatic parenchyma and colorectal liver metastases. Previous examination has demonstrated structurally normal but non-viable cells within the ablation zone. This study aimed to further investigate how ablation affects these cells, and to confirm non-viability. Materials and methods: Ablations were performed in ex vivo human hepatic parenchyma and tumour for a variety of time (10-180 s) and power (10-50 W) settings. Histological examination was performed to assess cellular anatomy, whilst enzyme histochemistry was used to confirm cellular non-viability. Transmission electron microscopy was used to investigate the subcellular structural effects of ablation within these fixed cells. Preliminary proteomic analysis was also performed to explore the mechanism of microwave cell death. Results: Increasing time and power settings led to a predictable and reproducible increase in size of ablation. At 50 W and 180 s application, a maximum ablation diameter of 38.8 mm (AE1.3) was produced. Ablations were produced rapidly, and at all time and power settings ablations remained spherical (longest:shortest diameter <1.2). Routine histological analysis using haematoxylin-eosin (H&E) confirmed well preserved cellular anatomy despite ablation. Transmission electron microscopy demonstrated marked subcellular damage. Enzyme histochemistry showed complete absence of viability in ablated tissue. Conclusions: Large spherical ablation zones can be rapidly and reproducibly achieved in ex vivo human hepatic parenchyma and colorectal liver metastases using a 14.5 GHz microwave generator. Despite well preserved cellular appearance, ablated tissue is non-viable.

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“…However, a number of local treatment methods for effective tumor destruction of unresectable liver tumors have recently received considerable interests. The procedures include cryoablation (CA) [19], radiofrequency ablation (RFA) [8], ethanol injection therapy (PEIT) [23], intratumoral chemotherapy [29], highintensity focused ultrasound (HIFU) [5], laser [28], and microwave ablation [9,15]. The major task of these therapeutic procedures is accurate needle placement according to pre-operative planning data, with the aim of complete removal of tumor and minimal damage to surrounding normal liver parenchyma.…”

Section: Introductionmentioning

confidence: 99%

Interventional navigation systems for treatment of unresectable liver tumor

Phee

Yang

2009

Med Biol Eng Comput

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Most patients with liver tumors are not candidates for surgical resection. A number of local treatment methods for unresectable liver tumors have recently received considerable interests. The major task of these procedures is accurate needle placement with the aim of complete tumor removal and minimal damage to surrounding normal liver parenchyma. In this article, we review the current status of interventional navigation system (INS) for treatment of unresectable liver tumors in terms of overall workflow, tracking systems, and research development. The conceptual design of INS consists of pre-operative and intra-operative modules. The tracking system falls into three types: optical, electromagnetic, and MR gradient based. The current INS, according to their image modalities, can be classified into four categories: MRI based, CT based, U/S based, and multimodalities based. The article also discusses the future research direction for enhanced performance of INS with real time imaging, high accuracy, high resolution, and friendly user-interface.

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Proof of concept percutaneous treatment system to enable fast and finely controlled ablation of biological tissue

Cited by 8 publications

References 16 publications

Applications of Microwaves in Medicine

Applications of Microwaves in Medicine

Microwave ablation ofex vivohuman liver and colorectal liver metastases with a novel 14.5 GHz generator

Interventional navigation systems for treatment of unresectable liver tumor

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