Prooxidant-Antioxidant Balance and Antioxidized LDL Antibody Level Values and Cardiac Function in Patients with Coronary Artery Disease

Rahsepar, Amir Ali; Mirzaee, Asadollah; Moodi, Fatemeh; Moohebati, Mohsen; Tavallaie, Shima; Eshraghi, Ali; Alavi, Maryam-Sadat; Khorashadizadeh, Fatemeh; Pourghadamyari, Hossein; Paydar, Roghayeh; Amini, Maral; Khojasteh, Roshanak; Mousavi, Somayeh; Sahebi, Maryam; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.

doi:10.1159/000339273

Cited by 9 publications

(6 citation statements)

References 72 publications

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“…There was also a significant positive correlation between serum IMA and PAB levels. Therefore, our study and the other studie [ 29 – 31 ] confirm that the PAB levels are increased in patients with CAD. We suggest that the PAB assay may be useful for a CAD risk predictor in diseases such as PE.…”

Section: Discussionsupporting

confidence: 86%

Importance of oxidative stress in the evaluation of acute pulmonary embolism severity

Sağcan

Konukoğlu²,

Uzun³

et al. 2022

BMC Pulm Med

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Background Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Our study was aimed to investigate whether oxidative stress markers can be used as clinical markers in the evaluation of acute PE (APE) severity. Methods 47 patients with objectively documented diagnosis of APE were recorded. Of these patients, 14 had low-risk PE, 16 had moderate-risk PE, and 17 had high-risk PE. 21 healthy subjects were also enrolled in this study. Ischemia-modified albumin (IMA), prooxidants-antioxidants balance (PAB), advanced protein oxidation products (AOPPs), and ferric reducing antioxidant power (FRAP) were measured as oxidative stress parameters to evaluate the role of oxidative stress. Results In the low-risk and moderate-risk APE groups, AOPPs and PAB levels were significantly higher and FRAP levels were significantly lower than those in the control group. AOPPs and IMA levels in the patients with high-risk PE were significantly higher than those in both the low-risk and moderate-risk APE patients. There was a significant correlation between levels of AOPPs and the levels of both IMA (r: 0.462, p < 0.001) and PAB (r:0.378, p < 0.005). Serum FRAP levels were negatively correlated with PAB (r:− 0.683, p < 0.001) and AOPPs levels (r:− 0,384, p < 0.001). There was also a significant positive correlation between the serum IMA and PAB levels. Conclusions We clearly demonstrated that reactive oxygen species formation is significantly enhanced in APE. IMA and AOPPs may be used as clinical markers in the evaluation of APE severity in clinical practice. However, further studies with larger patient populations and longer follow-up periods are required to confirm the mechanisms underlying these findings.

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Section: Discussionsupporting

confidence: 86%

Importance of oxidative stress in the evaluation of acute pulmonary embolism severity

Sağcan

Konukoğlu²,

Uzun³

et al. 2022

BMC Pulm Med

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“…Evidence indicates that oxidative stress might actively participate in the pathophysiology of obesity, hypertension and atherosclerosis, and might be associated with increased risk of cardiovascular diseases, vascular dysfunction, and the metabolic syndrome [1][2][3][4]. Recently, it has been shown that plasma 8-iso-prostaglandin F2α (8-iso-PG F2α) may be a reliable index of oxidative stress in humans [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men: An electron spin resonance investigation

Tsuda¹

2012

ABB

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There is evidence showing that increased levels of oxidative stress and C-reactive protein (CRP) might be associated with obesity, hypertension, atherosclerosis and other cardiovascular diseases. This study was undertaken to investigate possible relationships among plasma 8-iso-prostaglandin F2α (8-iso-PG F2α: an index of oxidative stress), high-sensitivity (hs)-CRP and membrane fluidity (a reciprocal value of microviscosity) in hypertensive and normotensive men using an electron spin resonance (ESR)-method. The order parameter (S) for the spin-label agents (5-nitroxide stearate) of red blood cell (RBC) membranes in the ESR spectra was significantly higher in hypertensive men than in normotensive men, indicating that membrane fluidity was decreased in hypertensive men. Both plasma 8-iso-PG F2α and hs-CRP levels were significantly increased in hypertensive men compared with normotensive men. In addition, plasma plasma 8-iso-PG F2α levels were correlated with plasma hs-CRP levels. In contrast, plasma nitric oxide (NO)-metabolites were lower in hypertensive men than in normotensive men, and inversely correlated with plasma 8-iso-PG F2α and hs-CRP. The order parameter(S) of RBCs was correlated with plasma 8-iso-PG F2α and plasma hs-CRP, and inversely correlated with plasma NO-metabolites, suggesting that reduced membrane fluidity of RBCs might be associated with increased oxidative stress, inflammation and endothelial dysfunction. Multivariate regression analysis also showed that, after adjusting for general risk factors, both plasma 8-iso-PG F2α and hs-CRP were significant determinants of membrane fluidity of RBCs. The ESR suggests that associations of oxidative stress and inflammation might have a close correlation with impaired rheologic behavior of RBCs and microcirculatory dysfunction in hypertensive men

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“…Так, пiдвищення титру ААТ до оЛПНЩ фiксували, в основному, при нестабiльному перебiгу IХС: гострий IМ [15], нестабiльна стенокардiя [16], гострий коронарний синдром [17]. У хворих на стабiльну IХС титри антитiл в бiльшостi дослiджень або не вiдрiзнялисяся вiд контролю [2,18], що збiгається з нашими результатами, або були зниженi [3].…”

Section: результати та їх обговоренняunclassified

Class G Autoantibodies to Oxidatively Modified Low Density Lipoprotein in Type 2 Diabetes Mellitus Patients Who Have Had Non-Q-Myocardial Infarction

Алтуніна

Lizogub

Bondarchuk

2021

PEP

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The article presents the results of a study of class G autoantibodies to oxidatively modified low-density lipoprotein (ox-LDL) in patients with type 2 diabetes mellitus which have had non-Qmyocardial infarction and their connection with disturbances of carbohydrate and lipid metabolism, the levels of cytokines. It was identified the decrease level of IgG to ox-LDL in the serum of these patients compared with the control group and patients without diabetes. The study found that with increasing degree of insulin resistance, the concentration of class G autoantibodies to ox-LDL in diabetic postinfarction patients was reduced. It was also revealed their direct connection with the level of anti-inflammatory IL-10. The data obtained may be evidence of the negative impact of carbohydrate metabolism disorders on the level of IgG autoantibodies to ox-LDL and the data may refer to their protective role in type 2 diabetes mellitus with concomitant atherosclerosis.

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Prooxidant-Antioxidant Balance and Antioxidized LDL Antibody Level Values and Cardiac Function in Patients with Coronary Artery Disease

Cited by 9 publications

References 72 publications

Importance of oxidative stress in the evaluation of acute pulmonary embolism severity

Importance of oxidative stress in the evaluation of acute pulmonary embolism severity

Associations of oxidative stress and inflammation and their role in the regulation of membrane fluidity of red blood cells in hypertensive and normotensive men: An electron spin resonance investigation

Class G Autoantibodies to Oxidatively Modified Low Density Lipoprotein in Type 2 Diabetes Mellitus Patients Who Have Had Non-Q-Myocardial Infarction

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