Prooxidant effects of chronic exposure to deltamethrin in green toad Bufotes viridis

Abstract

Pesticide-induced oxidative stress, as one of mechanism of toxicity, has been a focus of toxicological research. However, there is a lack of data for certain pesticides-oxidative stress effects especially on terrestrial amphibians. This study evaluates the prooxidative effects of orally administered insecticide deltamethrin (DM) in some tissues of the terrestrial toad Bufotes viridis. Toads were randomly divided and assigned to a control group and a test group that was orally exposed to the pesticide (5 mg/kg of body weight/daily) for 21 days. Animals were euthanized from each group on days 7, 14, and 21, and the liver, leg muscle, ventral skin, and gastrointestinal tissue (GIT) were dissected and used for analysis. From battery of investigated antioxidant components, superoxide dismutase (SOD) was the most differentiate parameter in all examined tissues. For the period of prolonged exposure to pesticide, antioxidative strategy of Bufotes viridis was based on SOD utilization in attempt to maintain the oxidative disbalance at acceptable level. The integrated biomarker response (IBR) as the measure of the overall biochemical response to DM exposure revealed that the group exposed for 21 days had the highest response. Our work has offered valuable data ensuring evidence that toads exposed to deltamethrin developed adaptive reactions that were tissue-specific and that DM-generated systemic toxicity was time-dependent. The present work showed that oxidative stress has significant role in pesticide-induced toxicity and contributes to better understanding of ecotoxicological risk in the terrestrial amphibians exposed to DM.

Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats

“…The alteration in the antioxidant status caused by pyrethroid pesticides, including deltamethrin, is often linked to changes in the activity of these enzymes (Gasmi et al, 2017; Nieradko-Iwanicka and Borzecki, 2015). The present findings are in accordance with the results of many investigators who illustrated that deltamethrin has pro-oxidative effects and can lead to organ toxicity via the change in the oxidative status (Kong et al, 2021; Nasia et al, 2018; Radovanoviíc et al, 2017). Moreover, deltamethrin was found to inhibit erythrocytes Cu – Zn – SOD, CAT, and GPx in treated animals to correct the levels of protein carbonyl (Manna et al, 2004; Yarsan et al, 2002).…”

The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians

“…After assessing for inclusion (Figure S1), we extracted 2,012 effect sizes from 86 studies (Acquaroni et al, 2021; Anguiano et al, 2001; Attademo et al, 2016; Awadalla et al, 2019; Barreto et al, 2020; Bhuyan et al, 2020; Burraco and Gomez-Mestre, 2016; Carvalho et al, 2020; Chai et al, 2017; Cheng et al, 2017; Cheron et al, 2022; Costa et al, 2008; Czarniewska et al, 2003; da Silva et al, 2021; David et al, 2012; De Lima Coltro et al, 2017; Dornelles and Oliveira, 2016; Ejilibe et al, 2018; Ezemonye and Tongo, 2010; Falfushynska et al, 2015; Falfushynska et al, 2017; Ferrari et al, 2008; Ferrari et al, 2009; Ferrari et al, 2011; Freitas et al, 2017; Gillardin et al, 2009; Huang et al, 2007; Isnas et al, 2012; Jiang et al, 2019; Jones et al, 2010; Kanter and Celik, 2012; Kostaropoulos et al, 2005; Lajmanovich et al, 2018b; Lajmanovich et al, 2018a; Lajmanovich et al, 2022; Li et al, 2017; Li et al, 2018a; Li et al, 2018b; Liendro et al, 2015; Liu et al, 2006; Liu et al, 2021; Loumbourdis, 2006; Lu et al, 2021; Mardirosian et al, 2015; Marques et al, 2013; Martins et al, 2017; Melvin, 2016; Mussi and Calcaterra, 2010; Naab et al, 2001; Nascimento et al, 2021; Nasia et al, 2018; Özkol et al, 2012; Pal et al, 2018; Papadimitriou and Loumbourdis, 2002; Peltzer et al, 2019; Radovanović et al, 2017; Radovanović et al, 2021; Rosenbaum et al, 2012; Rutkoski et al, 2020; Rutkoski et al, 2021; Saad et al, 2022; Salvaterra et al, 2013; Saria et al, 2014; Shi et al, 2018; Sotomayor et al, 2015; Svartz et al, 2020; Tang et al, 2018; Trachantong et al, 2017;…”