Prooxidant Effects of Maternal Smoking and Formula in Newborn Infants

Schwarz, Kathleen B.; Cox, Jeanne; Sharma, Savitri; Clement, Liliana; Witter, Frank R.; Abbey, Helen; Sehnert, Shelley S.; Risby, Terence H.

doi:10.1097/00005176-199701000-00016

Cited by 36 publications

(24 citation statements)

References 28 publications

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“…Chelchowska et al (43) revealed that cigarette smoking increases lipid peroxidation and decreases antioxidant capacity in pregnant women and umbilical cord blood, as they found that endogenous free radical defence system enzyme activities such as CAT, GPx and glutathione reductase were decreased by 30 %, 15 % and 37 % in smoking pregnant women. In parallel to previous studies (8,44), our study indicates that smoking pregnant women and their newborns have a higher concentration of oxidative stress parameters.…”

Section: Discussionsupporting

confidence: 90%

Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

Aydoğan

Durmaz

Ercan

et al. 2013

Archives of Industrial Hygiene and Toxicology

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Some of the genotoxic/carcinogenic substances or metabolites in cigarette smoke are capable of passing through the placenta and harming a newborn's health. Smoking is also known as a factor in the formation of oxidative damage and the main mechanism involved in the carcinogenic process. Predetermining this genotoxic risk can be successfully achieved by measuring certain parameters of oxidative stress. The comet assay is considered an important biomarker for the evaluation of genotoxic substances and is effective for detecting DNA damage caused by smoking. This study examined third trimester bloods and the cord blood of 28 actively smoking and 22 non-smoking mothers in terms of DNA damage and oxidative stress parameters. Cu/Zn superoxide dismutase (CuZn-SOD), malondialdehyde (MDA), catalase (CAT), plasma nitrite/nitrates (NO 2 -/NO 3 -), selenium-dependent glutathione peroxidase (Se-GPx), Cu, and Zn levels were measured as indicators of oxidative damage. There were no signifi cant increases in DNA damage of the actively smoking pregnant group in comparison with the non-smoking pregnant group, either in the third trimester or cord blood. Oxidative stress parameters of smoker and non-smoker groups were statistically different for MDA (p<0.05), CuZn-SOD (p<0.01), Se-GPx (p<0.05) values while the difference was not signifi cant for NO 2 -/NO 3 -, CAT, Zn, and Cu values. The same values were also investigated in cord blood, and only NO 2 /NO 3 -(p<0.01), Se-GPx (p<0.01 and CAT (p<0.001) values were found statistically different. Smoking mothers may have been exposed to more oxidative stress than non-smoking mothers.

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Section: Discussionsupporting

confidence: 90%

Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

Aydoğan

Durmaz

Ercan

et al. 2013

Archives of Industrial Hygiene and Toxicology

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“…Smoking mothers and their newborns had a higher concentration of oxidant status in previous studies [2,28]. However, we did not find any difference on MDA levels between smokers and non-smokers, in parallel to a previous study [13].…”

Section: Discussionsupporting

confidence: 82%

The influence of maternal smoking on maternal and newborn oxidant and antioxidant status

et al. 2008

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Maternal smoking may lead to decreased milk levels of vitamin E, as a result of making use of this antioxidant in order to limit lipid peroxidation, as well as may lead to a possible limitation on the transfer of lipophilic antioxidants including vitamin A from blood plasma to milk. Further investigations conducted in large populations will be needed to assess the effects of maternal smoking on the oxidant and antioxidant status of breast milk.

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“…The nongenetic consequence of the hyperglycemic intrauterine environment gives credence to increase the diabetes-induced congenital malformations ( Hertogh et al, 2006 ). Human and animal studies have demonstrated that one of the most important mechanisms of action of diabetes is by ROS increased formation, and hence increased embryonic and fetal oxidative stress ( Ermis et al, 2004 ;Schwarz et al, 1997 ). Various etiological factors are proposed in order to explain diabetes-related congenital defects, especially at the early stages of organogenesis, they result in severe embryonic damage.…”

Section: Discussion ▼mentioning

confidence: 99%

Maternal-Fetal Outcome, Lipid Profile and Oxidative Stress of Diabetic Rats Neonatally Exposed to Streptozotocin

Damasceno

Kiss²,

Sinzato³

et al. 2011

Exp Clin Endocrinol Diabetes

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Prooxidant Effects of Maternal Smoking and Formula in Newborn Infants

Cited by 36 publications

References 28 publications

Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

The influence of maternal smoking on maternal and newborn oxidant and antioxidant status

Maternal-Fetal Outcome, Lipid Profile and Oxidative Stress of Diabetic Rats Neonatally Exposed to Streptozotocin

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