Properdin Factor B(Bf) Allele BfF1 Specifies an HLA-B18 Diabetogenic Haplotype

Dornan, John; Allan, Patricia; Noel, Elke P.; Larsen, Bodil; Farid, Nadir R.

doi:10.2337/diab.29.6.423

Cited by 17 publications

(4 citation statements)

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“…The finding of HLA haplotypic arrange ments distincitve of autoimmune disease should not come as a complete surprise Thus an increase in the rare Bf allele F, in I.D.D.M. (Raum et al 1979), particularly in association with B18 (Bertrams et al 1979, Dornan et al 1980, was recently described. Moreover we found that, despite a normal gene frequency of C2* in Graves' disease, this allele tends to be distributed among HLA-B antigens differently in the disease group compared to controls (Noel e t al.…”

Section: Discussionmentioning

confidence: 96%

Polyglandular Autoimmune Disease and HLA

et al. 1980

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We have studied 25 patients with polyglandular autoimmune disease with respect to HLA antigens. Whereas the combination of insulin dependent diabetes with Graves’disease or atrophic thyroiditis was associated with an increase in HLA–B8, this was not found to be the case for patients with I.D.D.M. and goitrous thyroiditis. However 4/7 of these patients were DRw3 positive in contrast to previously established normal distribution of HLA–B8 in patients with goitrous thyroiditis alone. These data suggest that patients with polyglandular failure may be highly selected for HLA‐B8/DRw3 positivity. We also report on two families with polyglandular autoimmune disease; the results suggest that these disorders are not necessarily transmitted with B8/DRw3 bearing haplotypes. In one family both the affected mother and non‐affected father were B8 positive. The mother's B8, which was associated with DRw7, BfF and Rga did not appear to be involved in the transmission of disease susceptibility to two affected offspring. The search for complete haplotypic arrangement should be pursued to see whether this uncommon haplotype arrangement is peculiar to autoimmune diseases.

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Section: Discussionmentioning

confidence: 96%

Polyglandular Autoimmune Disease and HLA

et al. 1980

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“…In 1979 several groups (Raum et al 1979, Kirk et al 1979, Bertrams et al 1979, Deschamps et al 1979 reported independently an association between the rare BfFl factor in the properdin system and insulin-dependent diabetes mellitus (IDDM). Subsequent reports have confirmed this association for patients of European descent (Barbosa et al 1979, Dornan et al 1980, Bertrams et al 1981). In the series where HLA typing was carried out also the haplotype most commonly involved was HLA B18:BfFl:DR3.…”

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confidence: 79%

The rare factor BfSl of the properdin system strongly associated with insulin‐dependent diabetes in north India

Kirk¹,

Ranford²,

Theophilus³

et al. 1982

Tissue Antigens

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“…C2 deficiency marked by haplotype A10, B18, BfS, DR3 (Lachmann 1978), insulin dependent diabetes marked by B18 BfFl DR3 (Doman et al 1980;Kirk et al 1979;Räumet al 1979).…”

Section: Discussionmentioning

confidence: 96%