The rare factor BfSl of the properdin system strongly associated with insulin‐dependent diabetes in north India

Kirk, R. L.; Ranford, P.R.; Theophilus, J.; Ahuja, Hanna; Mehra, N. K.; Vaidya, M. C.

doi:10.1111/j.1399-0039.1982.tb00361.x

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1983

1994

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Cited by 12 publications

(2 citation statements)

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“…In contrast to previous results for north Indian IDDM patients (Kirk et al 1982), there is no significant difference in the BF S1 types between south Indian controls and either IDDM or NIDDM patients. This suggests that the susceptibility allele(s) for IDDM in south India arose independently from the susceptibility allele(s) in north India.…”

Section: Acknowledgmentcontrasting

confidence: 99%

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Another association between the properdin system (BF) and insulin‐dependent diabetes in south India

Kirk¹,

Ranford²,

Viswanathan

et al. 1983

Tissue Antigens

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Section: Acknowledgmentcontrasting

confidence: 99%

“…In a previous paper (Kirk et al 1982) we reported a strong association between the rare properdin factor B F S1 and insulin-dependent diabetes among patients in north India. We have now extended our study to include insulin-dependent diabetics in south India and have found a strong association with the BF F factor and no association with BF S1.…”

mentioning

confidence: 80%

Another association between the properdin system (BF) and insulin‐dependent diabetes in south India

Kirk¹,

Ranford²,

Viswanathan

et al. 1983

Tissue Antigens

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Family histories in Asian and European non‐insulin‐dependent diabetic patients

et al. 1986

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Family histories of 135 Asian Indian and 146 European NIDD patients attending clinics in Ealing and Hammersmith Hospitals were obtained, using a detailed questionnaire. Forty‐five per‐cent of Asian and 36% of European patients had a first‐degree relative with diabetes. Twenty‐eight per‐cent of Asians and 20% of Europeans had one diabetic parent. In 10% of Asians and 1% of Europeans, both parents were diabetic (p<0.01). Autosomal‐dominant inheritance was seen in 14% of Asians and 4% of Europeans (p<0.01). The higher frequency of diabetes in parents, and the higher frequency of dominantly‐inherited diabetes among Asians compared to European NIDD patients, suggest that genetic mechanisms operating in NIDD are different in different ethnic groups.

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Endocrinology

Tiwari

Terasaki²

1985

HLA and Disease Associations

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The rare factor BfSl of the properdin system strongly associated with insulin‐dependent diabetes in north India

Cited by 12 publications

References 12 publications

Another association between the properdin system (BF) and insulin‐dependent diabetes in south India

Another association between the properdin system (BF) and insulin‐dependent diabetes in south India

Family histories in Asian and European non‐insulin‐dependent diabetic patients

Endocrinology

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