Endocrinology

Tiwari, Jawahar L.; Terasaki, Paul I.

doi:10.1007/978-1-4613-8545-5_9

Cited by 24 publications

(6 citation statements)

References 263 publications

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“…In this study, we found a trend of increase in B7 and Bw60 and decrease in Bw61 and Bw62 frequencies in the patients with IDDM, although none reached statistically significant level when corrected P-value was calculated. This result was a contrast to HLA-B association with IDDM that had been found in other ethnic groups 1) . These differences suggest that the assoication of IDDM with HLA-DR locus is stronger than that with HLA-B locus.…”

Section: Discussioncontrasting

confidence: 90%

“…Also there was no difference in the incidence of DRw9 between the patients (12.2%) and the controls (21.1%). Amazingly, these data are similar to the results found in several diabetic populations of the European and North American Caucasians 1) . However, our results are different from the results found in the Japanese, Chinese and North Indian populations 4 , 10 – 13) .…”

Section: Discussionsupporting

confidence: 90%

“…Many studies of different ethnic groups have conclusively shown that the genetic susceptibility to insulin-dependent diabetes mellitus (IDDM) is HLA linked 1) . Among the various HLA specificities, the D/DR locus antigens have the closest associatioin with this disorder, the deviation in the frequency at the other HLA loci being secondary to their linkage with these antigens 2) .…”

Section: Introductionmentioning

confidence: 99%

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HLA and Insulin-Dependent Diabetes Mellitus in Koreans

Rhee

Choi

Park

et al. 1987

Korean J Intern Med

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Specific allelic associations vary among ethnic groups. We studied the distribution of HLA-A, -B, -C and -DR antigens in 41 patients with insulin-dependent diabetes mellitus (IDDM) and 280 unaffected persons in Korea. HLA typing was performed by the standard microlymphocytotoxicity test using antisera supplied by the Third Asia-Oceania Histocompatibility Workshop Conference (3rd AOHWC, 1986).There was no association between HLA-A, -B, or -C and IDDM. However, the frequencies of HLA-DR3 and HLA-DR4 were increased in the patients as compared with the controls (19.5% vs 4.3%, RR 5.4, corrected p < 0.005 for DR3 and 61.0% vs 36.4%, RR 2.7, corrected p < 0.05 for DR4). Also a decreased frequency of HLA-DR2 was found in the patients with IDDM (9.8% vs 32.1%, RR 0.3, corrected p < 0.05).These results emphasize the differences in HLA-IDDM associations among different ethnic groups.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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HLA and Insulin-Dependent Diabetes Mellitus in Koreans

Rhee

Choi

Park

et al. 1987

Korean J Intern Med

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“…Support for this view comes from studies of Type I diabetes in different racial groups. These show that whereas DR3 and DR4 are relatively consistently associated with the condition, the class I and 1II associations in various ethnic populations show considerable variation [3]. Linkage disequilibrium also exists within the HLA-D region itself and, therefore, it is inevitable that study of class II markers will also generate secondary associations.…”

mentioning

confidence: 96%

Class II HLA DNA polymorphisms in Type 1 (insulin-dependent) diabetic patients of North Indian origin

et al. 1988

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Genetic associations with Type 1 (insulin-dependent) diabetes may be primary or secondary to linkage disequilibrium. Studies of different racial groups should allow these to be distinguished. We have reported that Type 1 diabetes is associated with HLA-DR3 and -DR4 in subjects of North Indian (Punjab) origin and now present the results of a study of HLA class II DNA polymorphisms in this group and in white caucasoid subjects. DR4 in North Indian Type 1 diabetic patients was associated with DQ beta and DX alpha DNA polymorphisms identical to those found in DR4-positive white caucasoid patients. This DQ beta/DX alpha pattern was increased in frequency in North Indian diabetic patients vs control subjects (33.3% vs 8.5%, p less than 0.001, relative risk = 5.12 (95% confidence limits: 1.96-13.4)). A DQ beta polymorphism with very low relative risk for Type 1 diabetes in white caucasoid subjects was also markedly reduced in North Indian diabetic patients vs control subjects (2.3% vs 24.7%, p less than 0.02, relative risk = 0.10 (95% confidence limits: 0.02-0.46)). This pattern was associated with DR2 in white caucasoid subjects, but with DRw6 in North Indians. A DR3-associated DR beta polymorphism was markedly increased in North Indian diabetic patients vs control subjects (90.2% vs 40.7%, p less than 10(-6), relative risk = 12.1 (95% confidence limits: 4.32-33.9)). The DQ subregion may be a primary site of genetic influence on susceptibility to Type 1 diabetes. Further studies in different racial groups will clarify the HLA associations of Type 1 diabetes.

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“…Suspecting a possible association between the HLA alleles and genetic susceptibility for IDDM, as seen in other autoimmune disorders, researchers in the early 1970s documented relative risks in the two to threefold range for individuals who were HLA B8 and B15.l' Later, even stronger risks were found using these serologic techniques, as individuals with HLA DR3/DR4 were seen to have a relative risk ranging from 7 to 17. 16 Within the last year, however, an extremely strong association was found between IDDM and a short segment of the HLA-DQ beta chain gene. Using DNA amplified by the polymerase chain reaction and tested with DQ beta allele-specific oligonucleotide probes, researchers have found that the presence of an amino acid other than aspartic acid at position 57 of the HLA DQ beta chain (referred to as non-asp positivity) in the homozygous state is associated with a relative risk of 107 for the development of IDDM."…”

Section: The Genetics Of Iddmmentioning

confidence: 99%