The world of insulin‐dependent diabetes mellitus: What international epidemiologic studies reveal about the etiology and natural history of IDDM

Patrick, Sarah; Moy, Claudia S.; LaPorte, Ronald E.

doi:10.1002/dmr.5610050704

Cited by 22 publications

(8 citation statements)

References 14 publications

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“…There are many common elements among clinically distinct autoimmune diseases, including population frequencies (2), geographical distributions (23), clinical features (24), and therapeutic strategies. Most autoimmune diseases are thought to involve altered functions of humoral or cellular immunity.…”

mentioning

confidence: 99%

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

Becker

Simon

Bailey-Wilson

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

541

311

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Human autoimmune diseases are thought to develop through a complex combination of genetic and environmental factors. Genome-wide linkage searches of autoimmune and inf lammatory͞immune disorders have identified a large number of non-major histocompatibility complex loci that collectively contribute to disease susceptibility. A comparison was made of the linkage results from 23 published autoimmune or immune-mediated disease genome-wide scans. Human diseases included multiple sclerosis, Crohn's disease, familial psoriasis, asthma, and type-I diabetes (IDDM). Experimental animal disease studies included murine experimental autoimmune encephalomyelitis, rat inf lammatory arthritis, rat and murine IDDM, histamine sensitization, immunity to exogenous antigens, and murine lupus (systemic lupus erythematosus; SLE). A majority (Ϸ65%) of the human positive linkages map nonrandomly into 18 distinct clusters. Overlapping of susceptibility loci occurs between different human immune diseases and by comparing conserved regions with experimental autoimmune͞immune disease models. This nonrandom clustering supports a hypothesis that, in some cases, clinically distinct autoimmune diseases may be controlled by a common set of susceptibility genes.

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mentioning

confidence: 99%

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

Becker

Simon

Bailey-Wilson

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

541

311

View full text Add to dashboard Cite

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“…The ability to screen for diabetes related autoimmunity (autoantibodies to insulin, GAD65 and IA-2 and islet cell autoantibodies (ICA)) has allowed the identification of subjects at risk for diabetes prior to the development of hyperglycemia. While the majority of diabetes develops in the general population, the over all risk for diabetes in the general population is relatively small (prevalence of 1/300 children [35,36]). Therefore, these studies have screened a group with an increased a priori risk for diabetes, those with a family history of T1D for screening and potential intervention [37].…”

Section: Interventions With Autoimmunity Prior To Diabetesmentioning

confidence: 99%

Prevention strategies for type 1 diabetes

Kishiyama

Chase

Barker

2006

Rev Endocr Metab Disord

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Type 1 diabetes (T1D) is a common chronic disease of childhood. Patients with T1D are at significant risk for developing serious health complications. Understanding of the genetics, environmental factors, and natural history of diabetes has lead to greater understanding of the etiology and epidemiology of T1D. Furthermore, technology has greatly improved glycemic control and reduction of complications. However, prevention of the development of diabetes remains elusive. This review article describes the past, current and upcoming strategies for diabetes prevention for patients at risk for developing autoimmunity, after antibody production, and patients with new onset diabetes.

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“…A number of other findings also support this notion. For example, individuals who immigrate from a country with low IDDM incidence to one with high incidence adopt the higher disease rate of the new country (2). Furthermore, northern countries tend to have higher frequencies of IDDM than do southern countries (3), and the incidence of IDDM is increasing in countries such as Sardinia that have relatively stable genetic backgrounds (4).…”

Section: Insulin-dependent Diabetes Mellitus (Iddm)mentioning

confidence: 99%

The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.

Kraine

Tisch

1999

Environ Health Perspect

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Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease characterized by the destruction of the insulin-secreting P cells found in the islets of Langerhans. Reduced P-cell mass results in overt diabetes, requiring lifelong exogenous insulin administration and the possibility of numerous sequelae. Incidence and development of IDDM depend upon a variety of genetic and nongenetic factors. Environmental factors such as chemicals, diet, and infection are suspected to influence the development of disease. This review describes the work performed to date to elucidate the role of these environmental factors in IDDM. Key words: diet, drugs, environmental factors, infectious agents, insulin-dependent diabetes mellitus. -Environ Health Perspect 1 07(suppl 5):777-781 (1999). http.//ehpnetl.niehs.nih.gov/docs/1999/suppl-5/777-781kraine/abstract.html

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The world of insulin‐dependent diabetes mellitus: What international epidemiologic studies reveal about the etiology and natural history of IDDM

Cited by 22 publications

References 14 publications

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

Prevention strategies for type 1 diabetes

The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.

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