Properties and biodegradability of chitosan/nylon 11 blending films

Kuo, Ping Chung; Sahu, D. R.; Yu, Hsin Her

doi:10.1016/j.polymdegradstab.2006.07.025

Cited by 38 publications

(24 citation statements)

References 10 publications

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“…However, no significant shift in the diffraction peaks was observed, indicating that the presence of chitosan did not affect the ordered structure of PEO but only limited the nucleation process (Mucha et al, 1999;Peesan, Supaphol, & Rujiravanit, 2005). Similarly, chitosan has been reported to retard the crystallinity of films made of cellulose (Isogai & Atalla, 1992), poly(3-hydroxybutyric acid) (Ikejima & Inoue, 2000), nylon 11 (Kuo, Sahu, & Yu, 2006), polycaprolactone (Sarasam, Krishnaswamy, & Madihally, 2006), and poly(vinyl alcohol) (Chen, Wang, Mao, & Yang, 2007). This may be explained by that the chitosan molecular chains affected the overall mobility of polymers in the blend and impeded the rate of crystal growth (Zhao, Yu, Zhong, Zhang, & Sun, 1995).…”

Section: Film Crystallizationmentioning

confidence: 97%

Production and characterization of thick, thin and ultra-thin chitosan/PEO films

Zivanovic

Davidson

et al. 2011

Carbohydrate Polymers

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Section: Film Crystallizationmentioning

confidence: 97%

Production and characterization of thick, thin and ultra-thin chitosan/PEO films

Zivanovic

Davidson

et al. 2011

Carbohydrate Polymers

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“…The self‐assembly between gluten and chitosan template resulted in an amorphous/crystalline phase transition whose intensity was dependent on the protein:chitosan ratio used (Figure a), displaying two main reflections at 2θ 10.4° and 19.8°, being clearly observed a new reflection at 2θ = 22.0° for the gluten–chitosan supramolecular assembly formed at 1.9:1 protein to chitosan ratio. Higher crystallinity was also observed for this ratio, demonstrating a better long‐range ordering, which decreased for the 1.3:1 ratio. In order to extract the major sources of variation in the crystallinity structure of the gluten–chitosan supramolecular assemblies, a principal component analysis was performed (Figure b).…”

Section: Resultsmentioning

confidence: 99%

In Situ Gluten–Chitosan Interlocked Self‐Assembled Supramolecular Architecture Reduces T‐Cell‐Mediated Immune Response to Gluten in Celiac Disease

Ribeiro

Picascia

Rhazi

et al. 2018

Molecular Nutrition Food Res

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Scope The prevalence of celiac disease has increased since the last half of the 20th century and is now about 1% in most western populations. At present, people who suffer from celiac disease have to follow a gluten‐exclusion diet throughout their lives. Compliance to this restrictive diet is demanding and the development of alternative strategies has become urgent. Methods and results In this context, it is found that the biocompatible aminopolysaccharide chitosan imposes a different gluten reorganization after gluten redox reaction producing in situ mechanically interlocked supramolecular assemblies between gluten and chitosan. These new structures result in the decrease of gluten digestibility, tissue transglutaminase deamidation activity, and interferon‐γ production in intestinal T cell lines generated from biopsy specimens of celiac disease patients. Conclusion Overall, the results demonstrate the potential of this research avenue to celiac disease is problematic, as the reorganization of gluten proteins to a novel supramolecular architecture shows a positive impact on known pathogenesis mechanisms of the disease. At present, the only therapy for celiac disease is adherence to a gluten‐free diet. Here, it is shown that chitosan‐imposed gluten reorganization to an interlocked self‐assembled supramolecular architecture reduces gluten digestibility, R5‐reactivity, tissue transglutaminase deamidation activity, and its capacity to stimulate a T‐cell‐mediated immune response in celiac disease.

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“…Cs1‐Ms has been known to degrade slowly because of high crystallization in its net‐work structure. Numerous degradation studies of chitosan matrixes have been conducted examining different formulations and timescales 40, 41. As with many nonsoluble polysaccharides, chitosan undergoes bulk degradation through hydrolysis of the glycosidic bond.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous degradation studies of chitosan matrixes have been conducted examining different formulations and timescales. 40,41 As with many nonsoluble polysaccharides, chitosan undergoes bulk degradation through hydrolysis of the glycosidic bond. This form of random chain scission at the glycosidic bond allows maintenance of the network structure, but results in a decrease in mechanical strength of the bulk matrix.…”

Section: Discussionmentioning

confidence: 99%

Biological evaluation of a novel chitosan‐PVA‐based local delivery system for treatment of periodontitis

Wang

Chen

et al. 2008

J Biomedical Materials Res

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In the study, we intend to design a suitable localized drug delivery system (LDDS) with chitosan and poly vinyl alcohol (PVA) for treating serve periodontitis. For that, a novel formulation based on the incorporation of chitosan-based microspheres into PVA film was prepared. As the core parts of the novel formulation, chitosan-based microspheres were prepared form chitosan and/or carboxymethyl-chitosan (CM-chitosan) by using water-in-oil emulsification method. Then basic in vitro and in vivo experiments focusing on biocompatibility and biodegradability of the two chitosan-based microspheres were carried out to evaluate the feasibility of the novel LDDS. In vitro tests, besides having no hemolysis, chitosan microsphere (Cs1-Ms), and CM-chitosan microsphere (Cs2-Ms) have adsorbed little proteins on their surfaces. Moreover, plasma proteins adsorbed on Cs2-Ms, most of which can easily desorbed, are much less than that adsorbed on Cs1-Ms. This indicates that Cs2-Ms perhaps has better biocompatibility than Cs1-Ms. In vivo tests, Cs1-Ms and Cs2-Ms were subcutaneously implanted in rat to investigate the host tissue inflammatory response. Implantations of Cs1-Ms and Cs2-Ms induced a little more severe inflammation when compared with the implantation of PVA film. However, the difference on in vivo biocompatibility between Cs1-Ms and Cs2-Ms could not be confirmed by the implantation model of our experiments. Both Cs1-Ms and Cs2-Ms had suffered bioerosion when they were subcutaneously implanted. The hard and compact matrixes of Cs1-Ms were degraded very slowly, and only some trifling degradation had been found until 4 weeks of implantation. In contrast, Cs2-Ms is soft and more hydrophilic, and can be quickly degraded in a form of diffluence by the physiological circumstance. All these results suggested that Cs2-Ms had better potentials used as core parts of the novel designed LDDS in the future developments.

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Properties and biodegradability of chitosan/nylon 11 blending films

Cited by 38 publications

References 10 publications

Production and characterization of thick, thin and ultra-thin chitosan/PEO films

Production and characterization of thick, thin and ultra-thin chitosan/PEO films

In Situ Gluten–Chitosan Interlocked Self‐Assembled Supramolecular Architecture Reduces T‐Cell‐Mediated Immune Response to Gluten in Celiac Disease

Biological evaluation of a novel chitosan‐PVA‐based local delivery system for treatment of periodontitis

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