Properties of interpenetrating polymer networks associating fibrin and silk fibroin networks obtained by a double enzymatic method

Goczkowski, Mathieu; Gobin, Maxime; Hindié, Mathilde; Agniel, Rémy; Larreta‐Garde, Véronique

doi:10.1016/j.msec.2019.109931

Cited by 13 publications

(6 citation statements)

References 44 publications

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“…[117][118][119][120] DN hydrogels can be fabricated by implementing molds or in situ crosslinking. 121,122 The formation of DNs is also governed by either using enzymatic crosslinkers 123,124 or by self-assembling peptides. [125][126][127] Moreover, hydrophobic association, 128 ionic interactions, 129 metal-coordination complexes 130 along with supramolecular bonding 131 are explored towards the formation of DN hydrogels.…”

Section: Forecasting Of Tough Ipn Hydrogelsmentioning

confidence: 99%

Interpenetrating polymer network based hydrogel: A smart approach for corroborating wound healing of various capacity

Sarangi

Padhi

Patel

et al. 2023

J of Applied Polymer Sci

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Hemorrhage of high intensity usually leads to severe mortality accidents, disaster, and warfare. The concomitant wound thereby induces immense psychological as well as physical trauma to the patients. Hence, a faster hemostasis with smart wound healing approaches are highly essential to deal such critical/life threatening situations. The traditional approaches such as implementation of gauze and bandages are found to be having limited scope for controlling hemorrhage, because of non‐biodegradability, high susceptibility towards infection, unsuitability for irregular wound and ineffective towards wound healing. By virtue of the merits revealed by remodeling interpenetrating polymer network (IPN) based hydrogels (biocompatibility, high porosity, tunability, biomimetic and better retention, and proliferative wound healing tendency), have drawn a rigorous attention to out play their ancestors. This review includes the involvement of numerous synthetic routes, types and physicochemical properties of IPN based hydrogels loaded with diverse therapeutic agents towards wound repair/healing. Moreover, some of the recent patents have been portrayed in the manuscript, dignifying the potentiality of fascinating IPN hydrogels towards effective wound healing. More research is required to engineer multifaceted IPN hydrogels to attain huge potential against the challenges and future perspectives in wound healing.

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Section: Forecasting Of Tough Ipn Hydrogelsmentioning

confidence: 99%

Interpenetrating polymer network based hydrogel: A smart approach for corroborating wound healing of various capacity

Sarangi

Padhi

Patel

et al. 2023

J of Applied Polymer Sci

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“…Adding HRP/hydrogen peroxide (H 2 O 2 ) to the silk fibroin solution can form a stable, highly elastic, and transparent hydrogel, which is due to the fact that HRP promotes the cross-linking of tyrosine residues in fibroin molecular chains by forming free radicals in the presence of H 2 O 2 . 75 The concentrations of HRP and H 2 O 2 can control the mechanical properties of resultant silk fibroin hydrogels. Compared with physically cross-linked and other chemical cross-linking agent-derived hydrogels, HRP/H 2 O 2 catalyzed cross-linking to prepare silk fibroin hydrogels shows a series of advantages.…”

Section: Enzymatic Cross-linkingmentioning

confidence: 99%

“…Among them, HRP is the most popular enzymatic cross‐linking agent. Adding HRP/hydrogen peroxide (H 2 O 2 ) to the silk fibroin solution can form a stable, highly elastic, and transparent hydrogel, which is due to the fact that HRP promotes the cross‐linking of tyrosine residues in fibroin molecular chains by forming free radicals in the presence of H 2 O 2 75 . The concentrations of HRP and H 2 O 2 can control the mechanical properties of resultant silk fibroin hydrogels.…”

Section: Gelation Of Silk Fibroin Hydrogelmentioning

confidence: 99%

Silk fibroin hydrogels for biomedical applications

Zhang

et al. 2022

Smart Medicine

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Silk fibroin hydrogels occupy an essential position in the biomedical field due to their remarkable biological properties, excellent mechanical properties, flexible processing properties, as well as abundant sources and low cost. Herein, we introduce the unique structures and physicochemical characteristics of silk fibroin, including mechanical properties, biocompatibility, and biodegradability. Then, various preparation strategies of silk fibroin hydrogels are summarized, which can be divided into physical cross‐linking and chemical cross‐linking. Emphatically, the applications of silk fibroin hydrogel biomaterials in various biomedical fields, including tissue engineering, drug delivery, and wearable sensors, are systematically summarized. At last, the challenges and future prospects of silk fibroin hydrogels in biomedical applications are discussed.

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“…Studies have demonstrated that mixing SF solutions with natural biomolecular polymers could overcome some drawbacks of SF scaffolds ( Buitrago et al, 2018 ; Goczkowski et al, 2019 ). Type I collagen, a predominant subtype synthesized in connective tissue, is the most abundant collagen in human liver tissues with rich integrin-mediated cell-binding sites ( Martinez-Hernandez and Amenta, 1993 ; Willemse et al, 2020 ; Kumaran et al, 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Development of Biomimetic Hepatic Lobule-Like Constructs on Silk-Collagen Composite Scaffolds for Liver Tissue Engineering

Guo

Zhu

Gao

et al. 2022

Front. Bioeng. Biotechnol.

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Constructing an engineered hepatic lobule-mimetic model is challenging owing to complicated lobular architecture and crucial hepatic functionality. Our previous study has demonstrated the feasibility of using silk fibroin (SF) scaffolds as functional templates for engineering hepatic lobule-like constructs. But the unsatisfactory chemical and physical performances of the SF-only scaffold and the inherent defect in the functional activity of the carcinoma-derived seeding cells remain to be addressed to satisfy the downstream application demand. In this study, SF-collagen I (SFC) composite scaffolds with improved physical and chemical properties were fabricated, and their utilization for bioengineering a more hepatic lobule-like construct was explored using the immortalized human hepatocyte-derived liver progenitor-like cells (iHepLPCs) and endothelial cells incorporated in the dynamic culture system. The SFC scaffolds prepared through the directional lyophilization process showed radially aligned porous structures with increased swelling ratio and porosity, ameliorative mechanical stiffness that resembled the normal liver matrix more closely, and improved biocompatibility. The iHepLPCs displayed a hepatic plate-like distribution and differentiated into matured hepatocytes with improved hepatic function in vitro and in vivo. Moreover, hepatocyte–endothelial cell interphase arrangement was generated in the co-culture compartment with improved polarity, bile capillary formation, and enhanced liver functions compared with the monocultures. Thus, a more biomimetic hepatic lobule-like model was established and could provide a valuable and robust platform for various applications, including bioartificial liver and drug screening.

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Properties of interpenetrating polymer networks associating fibrin and silk fibroin networks obtained by a double enzymatic method

Cited by 13 publications

References 44 publications

Interpenetrating polymer network based hydrogel: A smart approach for corroborating wound healing of various capacity

Interpenetrating polymer network based hydrogel: A smart approach for corroborating wound healing of various capacity

Silk fibroin hydrogels for biomedical applications

Development of Biomimetic Hepatic Lobule-Like Constructs on Silk-Collagen Composite Scaffolds for Liver Tissue Engineering

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