Properties of nanocapsules obtained from oil-in-water nanoemulsions

Koroleva, M. Yu.; Nagovitsina, T.Y.; Yurtov, E. V.

doi:10.1016/j.mencom.2015.09.026

Cited by 21 publications

(4 citation statements)

References 10 publications

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“…Our previous study has shown that the solidified shell of the mixture of Tween 60 and Span 60 is formed on the surface of oil nanodroplets at the ambient temperature. This shell provide the efficient protection from coalescence and Ostwald ripening in NE [20,21]. Curcumin has a lipophilic nature, its molecule contains polar groups that impart amphiphilic properties.…”

Section: Resultsmentioning

confidence: 99%

Bioavailability of nanoemulsions modified with curcumin and cerium dioxide nanoparticles

Shirokikh¹,

Anikina²,

Zamyatina³

et al. 2023

Nanosystems: Phys. Chem. Math.

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In this work, the physicochemical properties and biological activity of nanoemulsions prepared from paraffin oil and stabilized by nonionic surfactants as carriers of curcumin and cerium dioxide nanoparticles were studied. An analysis of the results showed that curcumin was incorporated into the oil droplets while cerium dioxide nanoparticles were adsorbed on the surface of oil droplets. The nanoemulsion droplet size did not exceed 100 nm. The absence of toxicity to mouse embryonic fibroblasts in vitro and after a single intraperitoneal injection to mice in vivo makes the nanoemulsions promising drug carriers for advanced biomedical applications.KEYWORDS nanoemulsions, drug delivery, curcumin, cerium dioxide nanoparticles. ACKNOWLEDGEMENTS This research has been supported by the Russian Science Foundation (project 22-63-00082).

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Section: Resultsmentioning

confidence: 99%

Bioavailability of nanoemulsions modified with curcumin and cerium dioxide nanoparticles

Shirokikh¹,

Anikina²,

Zamyatina³

et al. 2023

Nanosystems: Phys. Chem. Math.

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“…Process parameters were fixed, in order not to add additional variability sources. The stabilization of lipid emulsions may benefit from using surfactants with equivalent hydrocarbon chains, hence the use of the pairs Tween 20/Span 20, Tween 40/Span 40, Tween 60/Span 60, and Tween 80/Span 80 [ 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

A Stepwise Framework for the Systematic Development of Lipid Nanoparticles

et al. 2022

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A properly designed nanosystem aims to deliver an optimized concentration of the active pharmaceutical ingredient (API) at the site of action, resulting in a therapeutic response with reduced adverse effects. Due to the vast availability of lipids and surfactants, producing stable lipid dispersions is a double-edged sword: on the one hand, the versatility of composition allows for a refined design and tuning of properties; on the other hand, the complexity of the materials and their physical interactions often result in laborious and time-consuming pre-formulation studies. However, how can they be tailored, and which premises are required for a “right at first time” development? Here, a stepwise framework encompassing the sequential stages of nanoparticle production for disulfiram delivery is presented. Drug in lipid solubility analysis leads to the selection of the most suitable liquid lipids. As for the solid lipid, drug partitioning studies point out the lipids with increased capacity for solubilizing and entrapping disulfiram. The microscopical evaluation of the physical compatibility between liquid and solid lipids further indicates the most promising core compositions. The impact of the outer surfactant layer on the colloidal properties of the nanosystems is evaluated recurring to machine learning algorithms, in particular, hierarchical clustering, principal component analysis, and partial least squares regression. Overall, this work represents a comprehensive systematic approach to nanoparticle formulation studies that serves as a basis for selecting the most suitable excipients that comprise solid lipid nanoparticles and nanostructured lipid carriers.

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“…At high Tween 80 concentrations, the amount of low HLB surfactant is insufficient for the stabilization of W/O emulsion from which O/W nanoemulsion is produced upon cooling the system. This also results in an increase in droplet sizes [26].…”

Section: Nanoemulsions Stabilized By Nonionic Surfactantsmentioning

confidence: 96%

Nano- and microcapsules as drug-delivery systems

Koroleva¹,

Bidanov²,

Yurtov³

2016

REFFIT

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Preparation of nano- and micrometer-size capsules with lipid core might have several biomedical applications for delivery of lipophilic drugs. Successful usage of these nano- and microcarriers depends on their colloidal stability. Emulsion based carriers for drug delivery: nanoemulsions, colloidosomes, and solid lipid particles have been investigated in thiswork. Diameters of oil droplets in nanoemulsions are equal to 15 and 20 nm, howeverthey are not stable to phase separation. In spite of large droplet diameters (several tens of micrometer), colloidosomes stabilized by heteroaggregates of oppositely charged SiO2 nanoparticles are stable toward creaming. Paraffin emulsions stabilized by Carbopol 940 have particles 190 nm in size and are also stable to creaming during several months. Encapsulation of lipophilic drugs tocopherol, hydrocortisone, nimesulide or curcumin does not cause changing diameters of nanoemulsion based nanocapsules. Incorporation of these drugs in paraffin particles leads to decreased or increased particle sizes, but in all specimens the sizes are equal or less than 700 nm and such particles can be used as microcapsules for lipophilic drug delivery.

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Properties of nanocapsules obtained from oil-in-water nanoemulsions

Cited by 21 publications

References 10 publications

Bioavailability of nanoemulsions modified with curcumin and cerium dioxide nanoparticles

Bioavailability of nanoemulsions modified with curcumin and cerium dioxide nanoparticles

A Stepwise Framework for the Systematic Development of Lipid Nanoparticles

Nano- and microcapsules as drug-delivery systems

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