Properties of polyethersulfone ultrafiltration membranes modified by polyelectrolytes

Kochan, J.; Wintgens, Thomas; Wong, John E.; Melin, Thomas

doi:10.1016/j.desal.2009.09.092

Cited by 35 publications

(36 citation statements)

References 9 publications

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“…10 Degradation of the film, triggered by changes in pH or other environmental stimuli, causes the gradual release of the drug. The release kinetics of protein during the degradation of multi-layer films has been studies by Wood et al 20 and Macdonald et al 21 Hammond and co-workers have developed an interesting 15 extension to the technique for inclusion of drugs in multi-layers. 22 The active ingredient was first incorporated into nano-particles, consisting of co-polymer micelles.…”

Section: Introductionmentioning

confidence: 99%

“…9 The technique has 50 also been used in the design of more efficient fuel cells, where membranes with high proton conductivity but also good methanol blocking properties, needed in such cells, were fabricated using LBL deposition method 10 . LBL based techniques have similarly been used in the development of integrated optics 11 , in the 55 fabrication of targeted wound dressing materials 12 , production of high conductivity 13 and free standing highly ductile biocompatible films 14 , design of ultrafiltration membranes 15 and engineering of superior amperometric bio-sensors. 16,17 The advances in applying LBL technique to synthesis of 60 superhydrophobic or superhydrophilic surfaces were reviewed by Jaber and Schlenoff.…”

Section: Introductionmentioning

confidence: 99%

“…In the current work we shall show that, due to the electrostatic nature of the interaction, this may indeed not be the case. We also investigate the equilibrium state of the mixed protein + polysaccharide layers in order to identify circumstances 15 where this film is a single mixed layer and those where it comprises of distinct individual multi-layers. It is known that polymers forming the multi-layers are capable of interdiffusion.…”

Section: Introductionmentioning

confidence: 99%

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Mixed protein–polysaccharide interfacial layers: effect of polysaccharide charge distribution

2012

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The influence of the polysaccharide charge distribution on the structure, thickness, and charge reversal of the interfacial layers, formed by adsorbed positively charged protein and oppositely charged polysaccharide, has been investigated using lattice-based self-consistent field (SCF) approach. We compare the adsorption behaviour of a uniformly charged polysaccharide model with that consisting of a short and a long block carrying different charge densities. For homogeneously charged 10 polysaccharide we observe a resulting interfacial layer that is closer to a mixed protein + polysaccharide film, rather than a multi-layer. We also find that the maximum adsorption of polysaccharide occurs at an optimal value of its charge, above and below which the adsorbed amount decreases. In contrast, for heterogeneously charged chains, as their charge is increasingly located on the shorter block, a much thicker interfacial layer results. In such cases the weakly charged longer blocks extend well away from 15 the surface into the solution. The interfacial film begins to resemble a multilayer with a primary protein and a distinct secondary polysaccharide layer. When the weakly charged long blocks still have a sufficient amount of negative charge, we also observe a reversal of the sign of surface potential from positive to a negative value. Our SCF calculated values for the reversed surface potential are of the order of −25 mV, in good agreement with several experimental results involving -potential measurements on 20 particles covered with such protein + polysaccharide films.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mixed protein–polysaccharide interfacial layers: effect of polysaccharide charge distribution

2012

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“…In this technique, a membrane with a charged surface is immersed in a solution of a macromolecule carrying opposite charges to those of the membrane surface. Commercial membranes with negative charges on their surface can be directly used [24,25] or classical membranes such as polysulfone and polyacrylonitrile can be functionalized with charged groups by surface modification. Polyelectrolyte multilayer (PEM) show selective permeability for different species ranging from smaller ions to large molecules such as proteins.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of polyacrylonitrile membranes modified with polyelectrolyte deposition for separating similar sized proteins

Mahlicli

Altınkaya

Yürekli

2012

Journal of Membrane Science

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a b s t r a c tOne of the challenges faced by ultrafiltration membranes is to separate proteins with a small difference in their molecular weights. Recently, some researchers tried to overcome this problem by using charged membranes. This study examined the use of layer by layer deposition of polyelectrolytes on the chemically-modified polyacyronitrile membrane to increase the selectivity of the ultrafiltration. The membranes were prepared by wet-phase inversion technique and polyethylenimine (PEI) and alginate (ALG) were chosen as cationic and anionic polyelectrolytes for the modification of the surfaces. Sieving coefficient data were obtained with myoglobin and lysozyme as model proteins. The influences of solution pH, ionic strengths of the protein and polyelectrolyte solution and the number of polyelectrolyte bilayers on both selectivity and throughput were investigated. The highest selectivity and throughput were achieved with the 1-bilayer PEI-ALG coated polyacrylonitrile (PAN) membrane. Increasing the number of coating bilayers or the ionic strength of the protein solution or adding salt into the polyelectrolyte coating solution decreased both the maximum selectivity and throughput of the modified membranes.

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“…The procedure has come to be known as the layer-by-layer (LbL) deposition technique. The potentials of the method for the fabrication of films with relatively complex but yet well controlled structures, have been explored in many varied fields of technology, since its introduction (Agarwal, et al, 2010;Aldea-Nunzi, Chan, Man, & Nunzi, 2013;Carosio, Alongi, & Malucelli, 2013;Du, Yang, Zhang, & Jiao, 2009;Johnston, Cortez, Angelatos, & Caruso, 2006;Kochan, Wintgens, Wong, & Melin, 2010;Podsiadlo, et al, 2009;Ramsden, Lvov, & Decher, 1995;Song, et al, 2013). The technique has been extended to include deposition of alternating layers of polymers and small nanoparticles (B. S. Kim, Park, & Hammond, 2008) and, more recently, vesicles (Roling, et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Colloidal interactions induced by overlap of mixed protein+polysaccharide interfacial layers

Ettelaie

Akinshina

2014

Food Hydrocolloids

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Colloidal interaction potentials induced by the overlap of mixed protein + polysaccharide interfacial layers, formed solely as a result of electrostatic attraction between these two biopolymers, have been calculated using the Self Consistent Field Theory. A significant difference between the nature and magnitude of these interactions, depending on the manner in which the charge is distributed along the length of the polysaccharide molecules, was predicted. For chains with an even distribution of charge, the repulsive interactions are in general weaker than those mediated by pure protein layers. For strongly charged polysaccharide chains, these become even attractive at a certain range of particle-particle separations. In part this is due to bridging by polysaccharides, occurring between opposite layers. However, in systems containing strongly charged polyelectrolyte, it is also the result of what in practice may be interpreted as a coacervate of protein + polysaccharide, with a tendency for aggregation, forming interfacial layers on the surface of the particles. In contrast, when the charge of the polysaccharide chains is unevenly distributed, the induced repulsive forces are much enhanced and become longer ranged compared to those for pure protein layers. Once the layers begin to overlap, the electro-steric interactions produced are found to completely overwhelm any van der Waals attraction, thus dictating the inter-particle interactions. We also present some preliminary calculations investigating the competitive adsorption of different polysaccharides onto the protein layer. The initial results, for polysaccharides of the same size and overall charge, suggest that the heterogeneously charged polyelectrolyte completely dominates the adsorption onto the surface, displacing all uniformly charged chains from the interface.

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Properties of polyethersulfone ultrafiltration membranes modified by polyelectrolytes

Cited by 35 publications

References 9 publications

Mixed protein–polysaccharide interfacial layers: effect of polysaccharide charge distribution

Mixed protein–polysaccharide interfacial layers: effect of polysaccharide charge distribution

Preparation and characterization of polyacrylonitrile membranes modified with polyelectrolyte deposition for separating similar sized proteins

Colloidal interactions induced by overlap of mixed protein+polysaccharide interfacial layers

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