Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Maideen, Naina Mohamed Pakkir

doi:10.3831/kpi.2020.23.010

Cited by 60 publications

(35 citation statements)

References 53 publications

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“…This supports the conclusion of the insignificant effect of ten days of Nigella sativa on mild COVID-19 cases. The results of the current study appear to conflict with the vast literature documenting the antiviral and anti-inflammatory effects of Nigella Sativa [ 3 , 21 , 22 , 23 ]. However, the literature is mainly based on in vitro and animal studies, and clinical trials on the impact of Nigella sativa in mild cases of infectious diseases are limited.…”

Section: Discussioncontrasting

confidence: 99%

“…Nigella sativa is one of the most used herbal products in various communities to prevent and treat many diseases. Nigella sativa has been reported to have antiviral, immunomodulation, antioxidant, and anti-inflammatory effects [ 2 , 3 ]. These beneficial effects are closely related to the pathophysiology of COVID-19, which led several investigators to suggest Nigella sativa as a potential treatment for SARS-CoV-2 infection [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial

Abdulrahman

Bamosa

Bukhari

et al. 2022

IJERPH

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The current study investigated the impact of different doses of Nigella sativa seeds on the symptoms, the cluster of differentiation profile group, and inflammatory markers of mild COVID-19 cases. Methods: The study was a double-blind placebo-controlled clinical trial. Patients with mild and asymptomatic SARS-CoV-2 infection patients were randomly subdivided into seven subgroups: Group (GP) 1: received charcoal capsules as a control group, and GP 2: received three capsules of whole Nigella sativa seeds daily, two capsules in the morning and one in the evening; GP 3: received three capsules of whole Nigella sativa seeds every 12 h, GP 4: received five capsules in the morning and four capsules of whole Nigella sativa seeds in the evening, GP 5: received one capsule of Nigella sativa powder every 12 h; GP 6: received two capsules of Nigella sativa powder every 12 h; GP 7: received three capsules of Nigella sativa powder every 12 h; all treatment course was for ten days. Inflammatory parameters were assessed before and after interventions. Results: 262 subjects were included in the final analysis. No significant difference was detected regarding age, gender, and nationality. No significant differences were detected between the inflammatory marker in all groups. The WBCs showed a significant difference between before and after the intervention. While for procalcitonin, a significant difference was demonstrated in groups 1,4, and 6. Conclusions: The current randomized clinical trial did not reveal a significant effect of ten days of treatment with various doses of Nigella sativa on symptoms, differentiation profile, and inflammatory markers of patients with COVID-19. As a natural product, the effect of Nigella sativa on disease requires weeks to manifest itself.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial

Abdulrahman

Bamosa

Bukhari

et al. 2022

IJERPH

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“…A herbal preparation that consists of Extracts of (Anthemis hyaline DC., N. sativa L., and Citrus sinensis (L.) Osbeck) was found to decrease the replication of CoV virus, as it increased IL-8 level, expression of the genes TRPA1, TRPC4, TRPM6, TRPM7, TRPM8, and TRPV4 changed significantly 84 . Several studies recommended N. sativa L. as an adjuvant therapy with repurposed drugs including Chloroquine, Hydroxychloroquine, Remdesivir, and Favipiravir used to manage patients with COVID-19 46 .Various randomized controlled trials, case reports, pilot studies, and in vitro and in vivo investigations confirmed that N. sativa L. possesses antiviral, antioxidant, anti-inflammatory, immunomodulatory, bronchodilatory, anti-histaminic, anti-tussive activities related to Coronavirus and signs of COVID-19 46 .…”

Section: In Vitro Studymentioning

confidence: 99%

“…These constituents include nigelledine, α-hederin, hederagenin, thymo-hydroquinone, and thymoquinone 85 . Besides, Nigellidine and α-hederin have been identified as a potential inhibitors of SARS CoV-2 6 .…”

Section: In Vitro Studymentioning

confidence: 99%

“…N. sativa L. seeds, powder, and volatile oil have recently been touted as a viable natural therapy that is effective against the SARS-CoV-2 virus and COVID-19 illness via many pathways. It has antiviral, antioxidant, anti-inflammatory, anticoagulant, immune-modulatory, bronchodilatory, antihistaminic, antitussive, antipyretic, and analgesic properties, and is utilized in the treatment of patients with COVID-19 6 . It was discovered that genetic diversity varies greatly depending on the geographical source.…”

Section: Introductionmentioning

confidence: 99%

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Nigella Sativa L.: A Golden Remedy: Significance Worldwide Highlighting Their Possible Use for Covid-19

Fayed

2022

Univ J Pharm Res

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Nigella sativa L. is a therapeutic natural herb that cures several serious ailments, so can be considered a Golden remedy. It has been used for centuries and has a long history in different cultures. This review article has surveyed nearly all the relevant literature on Nigella sativa L. from 1960-2020, offering a broad range of data including the origin, taxonomy, botany, history of traditional uses in different regions then passing through their phytochemistry, pharmacology, and consumed natural pharmaceutical preparations till recent findings and their possible use in COVID-19 therapy. The main aim of this review is to focus on the importance of Nigella sativa L. as a medicinal herb used widely in therapy and to correlate its phytochemical constituents with their pharmacological effects. The biological importance was attributed to Thymoquinone in the first-place present in the volatile oil of the seeds and other classes such as sterols, triterpenes, tannins, flavonoids, and cardiac glycosides, alkaloids, saponins, coumarins, volatile bases, glucosinolates, and anthraquinones. Moreover, several studies confirmed its benefits in Alzheimer’s disease, as a potent antioxidant, cytotoxic, antiallergic, antimicrobial, etc. In addition to other studies which documented the use of this plant mainly the seeds and the extracted essential oil, in the production of cosmeceutical preparations, and its role as a nutritive spice in the food industry due to its very low toxicity, besides their use as fodder for farm animals. Peer Review History: Received: 6 May 2022; Revised: 13 June; Accepted: 30 June, Available online: 15 July 2022 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Indonesia, ahmad.najib@umi.ac.id UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id Prof. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com Prof. Dr. Hüsniye Kayalar, Ege University, Turkey, husniyekayalar@gmail.com Similar Articles: COMPARISON BETWEEN THE EFFECTS OF THYMOQUINONE OBTAINED FROM THE SEEDS OF NIGELLA SATIVA AND VERAPAMIL ON THE VOLUME AND ACIDITY OF GASTRIC ACID SECRETION EUCALYPTUS ESSENTIAL OIL; AN OFF-LABEL USE TO PROTECT THE WORLD FROM COVID-19 PANDEMIC: REVIEW-BASED HYPOTHESES

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UV‐spectrophotometric and spectroscopic observed Vachellia nilotica and Nigella sativa formulations regularized the histopathological and biochemical parameters during wound contraction

Shahzad,

Ali,

Farooq

et al. 2024

Microscopy Res & Technique

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Diabetes mellitus causes impaired diabetic wounds which is linked to a number of pathological alterations that impede the healing of wounds. In the current research, Swiss albino mice were given alloxan monohydrate to induce diabetes and excision wounds of approximately 6 mm using biopsy punch. The diabetic wounds were treated with various biomaterials including Vachellia nilotica extract (VN), Nigella sativa extract (NS), V. nilotica nanoparticles (VNNPs) and N. sativa nanoparticles (NSNPs). Their effects were determined by evaluating the percent wound contraction, healing time, and histopathological analysis. The serum level of various biochemical parameters that is, pro‐inflammatory cytokines, Matrix metalloproteinases (MMPs) and tissue inhibitor matrix metalloproteinases (TIMPs) were also determined. VNNPs group provided the best outcomes, with wound contraction 100% on 12th day. According to histopathological examination, VNNPs group reduced inflammation and encouraged the formation of blood vessels, fibroblasts, and keratinocytes. VNNPs group significantly alleviated the serum level of pro‐inflammatory cytokines that are, TNF‐α (19.4 ± 1.5 pg/mL), IL‐6 (13.8 ± 0.6 pg/mL), and IL‐8 (24.8 ± 1.2 pg/mL) as compared with the diabetic mice. The serum level of MMP2 (248.2 ± 7.9 pg/mL), MMP7 (316 ± 5.2 pg/mL), and MMP9 (167.8 ± 12.1 pg/mL) in the same group VNNPs were also observed much less than the diabetic mice. The serum level of TIMPs (176.8 ± 2.9 pg/mL) in the VNNPs group was increased maximally with respect to diabetic mice. It is concluded that nanoparticles and biomaterials possess healing properties and have the ability to repair the chronic/diabetic wound.Research Highlights UV‐spectrophotometric and Fourier transform infrared spectroscopy observation for functional group analysis and possible linkage between conjugates Optimization of the histopathological and biochemical markers after application of the formulations Microscopic analysis of epithelial tissues for evaluation of healing mechanisms Speedy contraction of wounds as the alleviation of the inflammatory and necrotic factors

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Prophetic Medicine-Nigella Sativa (Black cumin seeds) – Potential herb for COVID-19?

Cited by 60 publications

References 53 publications

The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial

The Effect of Short Treatment with Nigella Sativa on Symptoms, the Cluster of Differentiation (CD) Profile, and Inflammatory Markers in Mild COVID-19 Patients: A Randomized, Double-Blind Controlled Trial

Nigella Sativa L.: A Golden Remedy: Significance Worldwide Highlighting Their Possible Use for Covid-19

UV‐spectrophotometric and spectroscopic observed Vachellia nilotica and Nigella sativa formulations regularized the histopathological and biochemical parameters during wound contraction

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