“…In randomized controlled trials of prophylactic synthetic mesh placement to prevent hernia formation during contaminated cases such as cholecystectomy, stoma reversal, and bariatric surgery, synthetic mesh has been shown to decrease rates of hernia formation without dramatically increasing the rates of SSI (for prophylactic mesh versus suture for umbilical trochar site following laparoscopic cholecystectomy: hernia OR 10.1, 95% CI 2.2-47.6; SSI OR 2.0, 95% CI 1.7-2.5). [109][110][111][112] These studies include both intraperitioneal and preperitoneal mesh placement. However, in a randomized controlled trial of prophylactic biologic matrix placement to prevent hernia formation during contaminated cases like bariatric surgery, biologic matrix has not been shown to decrease rates of hernia formation (OR 0.9, 95% CI 0.5-1.5).…”