Prophylactic Oophorectomy: Yes/No Risk vs Benefits

Epidemiology of Ovarian Cancer Ovarian cancer ranks as the fifth leading cause of malignancyassociated mortality in females (10,11). In 2008, an estimated 225,500 women were diagnosed as having ovarian cancer worldwide, and in 2012 it was estimated that there were 238,700 new cases, and 151,900 women died of ovarian cancer (12). In general, ovarian cancer is more common in developed countries than developing countries with the highest incidence in Northern Europe (13.3 per 100,000 per year) and the lowest incidence in North Africa (2.6 per 100,000 per year). In Asia, the estimated incidence of ovarian cancer in China is 3.2 per 100,000 per year (12). In Indonesia, there are no national data on the incidence of ovarian cancer, but in 2002 it was estimated that 829 new cases were diagnosed (2). The incidence of ovarian cancer increases with age, with a peak incidence at the age of 50-60 years (3,4).

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“…Women with a first-degree relative with ovarian cancer have a three to four-fold increased risk of developing ovarian cancer (27).…”

Section: Prophylactic Surgical Methods In Brca1/2 Genes Mutationmentioning

confidence: 99%

Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery

Budiana¹,

Angelina²,

Pemayun³

2018

J Turkish German Gynecol Assoc

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“…It is important to identify women at high risk, including the presence of BRCA mutation in the family, early-onset breast cancer, ovarian cancer at any age, male breast cancer, and Ashkenazi Jewish ancestry (26). Women with a first-degree relative with ovarian cancer have a three to four-fold increased risk of developing ovarian cancer (27).…”

Section: Introductionmentioning

confidence: 99%

Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery

Budiana

Angelina

Pemayun

2019

J Turkish German Gynecol Assoc

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Ovarian cancer is one of the most common gynecologic cancers, and one of the leading causes of cancer-associated female mortality in the world. Currently, no widely accepted pathogenesis is available, which may explain the entire disease. Early detection and primary prevention of ovarian cancer are difficult, mostly due to its heterogeneous nature. Risk factor modification based on epidemiologic data has not significantly reduced the incidence of ovarian cancer. Currently, prophylactic surgical methods have been proposed as the most effective preventive measures for both the high-risk or low-risk populations. Understanding the existing pathogenesis theories and the surgical options available may alter physician’s perspectives and facilitate better decision making.

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Prophylactic Oophorectomy: Yes/No Risk vs Benefits

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Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery

Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery

Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery

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