Prophylactic supplementation of sinapic acid ameliorates zoledronic acid induced changes in osteoblast survival and differentiation

Sadhasivam, Deepa Rani; Soundararajan, Sangeetha; Elumalai, Shalini; Karuppiah, Ponmurugan; Al-Dhabi, Naïf Abdullah

doi:10.1016/j.bcab.2020.101700

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…Sinapic acid is recognized as a potent antioxidant with osteogenic properties. Sadhasivam et al [35] discovered that zoledronic acid decreased osteoblast viability and inhibited differentiation. Conversely, treatment with sinapic acid led to an increase in the expression levels of osteoblast marker genes, including Runx2, Col-I, and ALP.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, treatment with sinapic acid led to an increase in the expression levels of osteoblast marker genes, including Runx2, Col-I, and ALP. Sinapic acid also promoted osteoblast differentiation and mineralization by enhancing calcium deposition [35]. Moreover, Sinapic acid-loaded chitosan scaffolds are used for bone regeneration [44] and phenolic compounds have the potential to prevent bone defects by modulating osteoblast activity [45].…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that ingredients such as proline [33], citric acid [34], sinapic acid [35], and tannin [36] contained in SB or SBP promote bone health by differentiating osteoblasts. However, no research has yet been conducted on the osteoblast activity of SB or SBP.…”

Section: Introductionmentioning

confidence: 99%

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Sword Bean (Canavalia gladiata) Pods Induce Differentiation in MC3T3-E1 Osteoblast Cells by Activating the BMP2/SMAD/RUNX2 Pathway

Hwang,

et al. 2023

Nutrients

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Sword bean (SB) contains various phytochemicals, such as flavonoids, tannins, saponins, and terpenoids. Although the evaluation of its potential functions, including antioxidant, anti-obesity, anti-inflammatory, liver protection, and antiangiogenic activities, has been widely reported, research on their use in osteoporosis prevention is insufficient. Furthermore, while various studies are conducted on SB, research on sword bean pods (SBP) is not yet active, and little is known about it. Therefore, this study investigated the effects of promoting osteoblast differentiation of MC3T3-E1 cells using SB and SBP extracts and their mechanisms. We show that SBP extracts increase osteoblast proliferation, mineralization-activated alkaline phosphatase (ALP), and collagen synthesis activities. Additionally, treatment with SBP extract increased the expression of markers related to osteoblast differentiation, such as ALP, SPARC, RUNX2, COL-I, BMP2, OCN, and OPN. It was confirmed that SBP induces differentiation by activating the BMP2/SMAD/RUNX2 pathway. We also show that SBP is more effective than SB, and SBP may be useful in assimilating bone minerals and preventing osteoporosis.

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Section: Discussionmentioning

confidence: 99%